{"created":"2024-12-12T09:58:44.137280+00:00","id":2011190,"links":{},"metadata":{"_buckets":{"deposit":"aaae8612-d8bc-4303-aaa6-1a5d329f2ac8"},"_deposit":{"created_by":7,"id":"2011190","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011190"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011190","sets":["1713853213384:1713853295607"]},"author_link":["1448"],"control_number":"2011190","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageStart":"1269","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Pharmaceutics","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The intrinsic histone acetyltransferase (HAT), p300, has an important role in the development and progression of heart failure. Curcumin (CUR), a natural p300-specific HAT inhibitor, suppresses hypertrophic responses and prevents deterioration of left-ventricular systolic function in heart-failure models. However, few structure–activity relationship studies on cardiomyocyte hypertrophy using CUR have been conducted. To evaluate if prenylated pyrazolo curcumin (PPC) and curcumin pyrazole (PyrC) can suppress cardiomyocyte hypertrophy, cultured cardiomyocytes were treated with CUR, PPC, or PyrC and then stimulated with phenylephrine (PE). PE-induced cardiomyocyte hypertrophy was inhibited by PyrC but not PPC at a lower concentration than CUR. Western blotting showed that PyrC suppressed PE-induced histone acetylation. However, an in vitro HAT assay showed that PyrC did not directly inhibit p300-HAT activity. As Cdk9 phosphorylates both RNA polymerase II and p300 and increases p300-HAT activity, the effects of CUR and PyrC on the kinase activity of Cdk9 were examined. Phosphorylation of p300 by Cdk9 was suppressed by PyrC. Immunoprecipitation-WB showed that PyrC inhibits Cdk9 binding to CyclinT1 in cultured cardiomyocytes. PyrC may prevent cardiomyocyte hypertrophic responses by indirectly suppressing both p300-HAT activity and RNA polymerase II transcription elongation activity via inhibition of Cdk9 kinase activity.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"19994923","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Masafumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"船本","familyNameLang":"ja"},{"familyName":"フナモト","familyNameLang":"ja-Kana"},{"familyName":"Funamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"雅文","givenNameLang":"ja"},{"givenName":"マサフミ","givenNameLang":"ja-Kana"},{"givenName":"Masafumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1448","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"376095/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/376095/profile-ja.html"},{"nameIdentifier":"40882064","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40882064"}]},{"creatorNames":[{"creatorName":"スナガワ, ヨウイチ","creatorNameLang":"ja"},{"creatorName":"スナガワ, ヨウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Sunagawa, Yoichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ゲンペイ, マイ","creatorNameLang":"ja"},{"creatorName":"ゲンペイ, マイ","creatorNameLang":"ja-Kana"},{"creatorName":"Gempei, Mai","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"シミズ, カナ","creatorNameLang":"ja"},{"creatorName":"シミズ, カナ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimizu, Kana","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カタナサカ, ヤスフミ","creatorNameLang":"ja"},{"creatorName":"カタナサカ, ヤスフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Katanasaka, Yasufumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"シミズ, サトシ","creatorNameLang":"ja"},{"creatorName":"シミズ, サトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimizu, Satoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハマベ ホリイケ, トシヒデ","creatorNameLang":"ja"},{"creatorName":"ハマベ ホリイケ, トシヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Hamabe-Horiike, Toshihide","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Appendino, Giovanni","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Minassi, Alberto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Koeberle, Andreas","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コミヤマ, マキ","creatorNameLang":"ja"},{"creatorName":"コミヤマ, マキ","creatorNameLang":"ja-Kana"},{"creatorName":"Komiyama, Maki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリ, キヨシ","creatorNameLang":"ja"},{"creatorName":"モリ, キヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Mori, Kiyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハセガワ, コウジ","creatorNameLang":"ja"},{"creatorName":"ハセガワ, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Hasegawa, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリモト, タツヤ","creatorNameLang":"ja"},{"creatorName":"モリモト, タツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Morimoto, Tatsuya","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-08-22"}],"displaytype":"detail","filename":"pharm_14_6_1269.pdf","filesize":[{"value":"2.38 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011190/files/pharm_14_6_1269.pdf"},"version_id":"7491496d-455d-4f44-aaaf-645cfb5b5a94"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cardiomyocyte hypertrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"p300","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"curcumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"histone acetyltransferase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cdk9","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"phosphorylation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pyrazole-Curcumin Suppresses Cardiomyocyte Hypertrophy by Disrupting the CDK9/CyclinT1 Complex","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pyrazole-Curcumin Suppresses Cardiomyocyte Hypertrophy by Disrupting the CDK9/CyclinT1 Complex","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-08-22"},"publish_date":"2023-08-22","publish_status":"0","recid":"2011190","relation_version_is_last":true,"title":["Pyrazole-Curcumin Suppresses Cardiomyocyte Hypertrophy by Disrupting the CDK9/CyclinT1 Complex"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-03T02:46:17.221765+00:00"}