{"created":"2024-12-12T09:58:50.662579+00:00","id":2011191,"links":{},"metadata":{"_buckets":{"deposit":"f400d5af-020c-4955-a499-e5e0360506b4"},"_deposit":{"created_by":7,"id":"2011191","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011191"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011191","sets":["1713853213384:1713853295607"]},"author_link":["1448","482"],"control_number":"2011191","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"High-absorption curcumin reduces BNP in hypertensive heart disease","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-09-10","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"oeac057","bibliographicVolumeNumber":"2","bibliographic_titles":[{"bibliographic_title":"European Heart Journal Open","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Aims\nHypertension is a strong risk factor for heart failure with preserved ejection fraction. Curcumin has p300-specific histone acetyltransferase inhibitory activity, suppresses cardiomyocyte hypertrophy and fibrosis, and significantly reduces myocardial brain natriuretic peptide (BNP) expression without altering blood pressure in a rat model of hypertensive heart disease. This double-blind, placebo-controlled, randomized study, for the first time, aimed to examine the efficacy of a high-absorption curcumin for the prevention of hypertensive heart disease in humans.\nMethods and results\nPatients exhibiting initial signs of hypertensive heart disease with left ventricular ejection fraction ≥60% and stable blood pressure <140/90 mmHg orally took a double-blinded capsule (either a 90 mg curcumin capsule or placebo) twice daily for 24 weeks. The primary endpoint was per cent changes in left ventricular diastolic function (E/E′) from baseline to 6 months after administration. The secondary endpoint was the per cent change in plasma BNP levels. The E/E′ ratio per cent change from baseline to 6 months after administration was similar between the placebo (n = 69) and the curcumin (n = 73) groups. The per cent change in plasma BNP levels was significantly lower in the curcumin group than in the placebo group. In patients <65 years, BNP per cent changes were significantly lower in the curcumin group than in the placebo group, but similar between groups in ≥65 years (<65 vs. ≥65 years: P for interaction = 0.011).\nConclusions\nA high-absorption curcumin agent did not affect the E/E′ ratio, rather it significantly inhibited the increase in plasma BNP levels in patients with initial signs of hypertensive heart disease.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"},{"subitem_publisher":"European Society of Cardiology","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"27524191","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Hiromichi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"池田, 康将","creatorNameLang":"ja"},{"creatorName":"イケダ, ヤスマサ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikeda, Yasumasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"池田","familyNameLang":"ja"},{"familyName":"イケダ","familyNameLang":"ja-Kana"},{"familyName":"Ikeda","familyNameLang":"en"}],"givenNames":[{"givenName":"康将","givenNameLang":"ja"},{"givenName":"ヤスマサ","givenNameLang":"ja-Kana"},{"givenName":"Yasumasa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"219499/profile-ja.html","nameIdentifierScheme":"徳島大学 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KB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011191/files/ehjo_2_5_oeac057.pdf"},"version_id":"0f94f276-04af-48a3-8e13-8435a219d4f9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Curcumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Hypertension","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cardiac hypertrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Diastolic dysfunction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"B-type natriuretic peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Prevention","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of high-absorption curcumin for the prevention of hypertensive heart disease : a double-blind, placebo-controlled, randomized clinical study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of high-absorption curcumin for the prevention of hypertensive heart disease : a double-blind, placebo-controlled, randomized clinical study","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-08-22"},"publish_date":"2023-08-22","publish_status":"0","recid":"2011191","relation_version_is_last":true,"title":["Effects of high-absorption curcumin for the prevention of hypertensive heart disease : a double-blind, placebo-controlled, randomized clinical study"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T05:58:37.922425+00:00"}