{"created":"2024-12-12T09:59:10.131484+00:00","id":2011194,"links":{},"metadata":{"_buckets":{"deposit":"515b6c77-0714-4876-8362-26b51a98396e"},"_deposit":{"created_by":7,"id":"2011194","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011194"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011194","sets":["1713853213384:1713853295607"]},"author_link":["482","1448","816","1567"],"control_number":"2011194","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-07-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"37","bibliographicPageStart":"31","bibliographicVolumeNumber":"153","bibliographic_titles":[{"bibliographic_title":"Journal of Pharmacological Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background and purpose: TJ-17 (Goreisan), a traditional Japanese Kampo medicine, has been generally used to treat edema, such as heart failure, due to its diuretic effect. In the present study, we investigate the effects of TJ-17 on chronic kidney disease (CKD).\nMethods: We the preventive action of TJ-17 against acute kidney injury (AKI) transition to CKD in vivo using a folic acid (FA)-induced mouse model. Mice were treated with food containing TJ-17 at 48 h after FA intraperitoneal injection (AKI phase).\nResults: Histological analysis, as well as renal function and renal injury markers, deteriorated in mice with FA-induced CKD and were ameliorated by TJ-17 treatment. Increased levels of inflammatory cytokines and macrophage infiltration were also alleviated in mice treated with TJ-17. Renal fibrosis, a crucial factor in CKD, was induced by FA administration and inhibited by TJ-17 treatment. Pretreatment with TJ-17 did not exert an inhibitory effect on FA-induced AKI. The increase in urinary volume in FA-induced CKD mice was ameliorated by TJ-17 treatment, with a concurrent correction of reduced aquaporins expression in the kidney.\nConclusion: TJ-17 may have a novel preventive effect against inflammation, oxidative stress, and fibrosis, contributing to innovation in the treatment of CKD.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"Japanese Pharmacological Society","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2023 The Authors. Production and hosting by Elsevier B.V. on behalf of Japanese Pharmacological Society. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13478648","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.jphs.2023.07.001"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jphs.2023.07.001","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"399186"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"スエナガ, アオイ","creatorNameLang":"ja"},{"creatorName":"スエナガ, アオイ","creatorNameLang":"ja-Kana"},{"creatorName":"Suenaga, Aoi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"セト, ヤスユキ","creatorNameLang":"ja"},{"creatorName":"セト, ヤスユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Seto, Yasuyuki","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"船本, 雅文","creatorNameLang":"ja"},{"creatorName":"フナモト, マサフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Funamoto, Masafumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"船本","familyNameLang":"ja"},{"familyName":"フナモト","familyNameLang":"ja-Kana"},{"familyName":"Funamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"雅文","givenNameLang":"ja"},{"givenName":"マサフミ","givenNameLang":"ja-Kana"},{"givenName":"Masafumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1448","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"376095/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/376095/profile-ja.html"},{"nameIdentifier":"40882064","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40882064"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"今西, 正樹","creatorNameLang":"ja"},{"creatorName":"イマニシ, マサキ","creatorNameLang":"ja-Kana"},{"creatorName":"Imanishi, Masaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"今西","familyNameLang":"ja"},{"familyName":"イマニシ","familyNameLang":"ja-Kana"},{"familyName":"Imanishi","familyNameLang":"en"}],"givenNames":[{"givenName":"正樹","givenNameLang":"ja"},{"givenName":"マサキ","givenNameLang":"ja-Kana"},{"givenName":"Masaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"816","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"305780/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/305780/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"土屋, 浩一郎","creatorNameLang":"ja"},{"creatorName":"ツチヤ, コウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuchiya, Koichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"土屋","familyNameLang":"ja"},{"familyName":"ツチヤ","familyNameLang":"ja-Kana"},{"familyName":"Tsuchiya","familyNameLang":"en"}],"givenNames":[{"givenName":"浩一郎","givenNameLang":"ja"},{"givenName":"コウイチロウ","givenNameLang":"ja-Kana"},{"givenName":"Koichiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1567","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60114/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60114/profile-ja.html"},{"nameIdentifier":"70301314","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70301314"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"池田, 康将","creatorNameLang":"ja"},{"creatorName":"イケダ, ヤスマサ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikeda, Yasumasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"池田","familyNameLang":"ja"},{"familyName":"イケダ","familyNameLang":"ja-Kana"},{"familyName":"Ikeda","familyNameLang":"en"}],"givenNames":[{"givenName":"康将","givenNameLang":"ja"},{"givenName":"ヤスマサ","givenNameLang":"ja-Kana"},{"givenName":"Yasumasa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"219499/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/219499/profile-ja.html"},{"nameIdentifier":"60432754","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60432754"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-08-22"}],"displaytype":"detail","filename":"jphs_153_1_31.pdf","filesize":[{"value":"1.42 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011194/files/jphs_153_1_31.pdf"},"version_id":"40cab544-4f4b-4050-b591-74d97f39a7d2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CKD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Goreisan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Fibrosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"TJ-17 (Goreisan) mitigates renal fibrosis in a mouse model of folic acid-induced chronic kidney disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"TJ-17 (Goreisan) mitigates renal fibrosis in a mouse model of folic acid-induced chronic kidney disease","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-08-22"},"publish_date":"2023-08-22","publish_status":"0","recid":"2011194","relation_version_is_last":true,"title":["TJ-17 (Goreisan) mitigates renal fibrosis in a mouse model of folic acid-induced chronic kidney disease"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-03T02:46:18.664441+00:00"}