{"created":"2024-12-12T09:59:30.492482+00:00","id":2011197,"links":{},"metadata":{"_buckets":{"deposit":"20bf1038-1345-4dfa-bdc2-2fedc0ecb52d"},"_deposit":{"created_by":7,"id":"2011197","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011197"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011197","sets":["1713853213384:1713853295607"]},"author_link":["183","341","231","1437","540","197","1517","1159","413","340","309"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-07-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"472","bibliographicPageStart":"467","bibliographicVolumeNumber":"82","bibliographic_titles":[{"bibliographic_title":"Journal of Cardiology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Cancer therapeutics-related cardiac dysfunction (CTRCD) affect the prognosis of patients with breast cancer. Echocardiographic surveillance of patients treated with anti-HER2 antibodies has been recommended, but few reports have provided evidence on patients with breast cancer only. We aimed to evaluate the effectiveness of echocardiographic surveillance for breast cancer patients.\nMethods: We identified 250 patients with breast cancer who were treated with anti-HER2 antibodies from July 2007 to September 2021. We divided 48 patients with echocardiographic surveillance every 3 months into the surveillance group and 202 patients without echocardiographic surveillance into the non-surveillance group. In the surveillance group, patients with a considerable reduction in GLS of 15% were considered for the initiation of cardioprotective drugs. The composite outcome of CTRCD and acute heart failure was the study endpoint.\nResults: The mean age was 59 ± 12 years. During the follow-up period of 15 months (12-17 months), 12 patients reached the endpoint. The surveillance group had significantly lower incidence of the composite outcome (2.1% vs. 5.5%, adjusted odds ratio: 0.28, 95% confidential intervals: 0.09–0.94; p=0.039) and higher rates of prescriptions of cardioprotective drugs than the non-surveillance group.\nConclusions: The incidence of cardiac complications was significantly lower in the surveillance group than the non-surveillance group, which supports the effectiveness of echocardiographic surveillance in patients with breast cancer.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese College of Cardiology","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09145087","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"18764738","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AN10070473","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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