{"created":"2024-12-12T10:01:20.109798+00:00","id":2011213,"links":{},"metadata":{"_buckets":{"deposit":"8a8f4312-fda2-4c5e-80ab-620b8f4bd821"},"_deposit":{"created_by":7,"id":"2011213","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011213"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011213","sets":["1713853213384:1713853295607"]},"author_link":["1413"],"control_number":"2011213","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-12","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"95","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"Journal of Experimental & Clinical Cancer Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Mitochondrial fusion and fission proteins have been nominated as druggable targets in cancer. Whether their inhibition is efficacious in triple negative breast cancer (TNBC) that almost invariably develops chemoresistance is unknown.\nMethods: We used a combination of bioinformatics analyses of cancer genomic databases, genetic and pharmacological Optic Atrophy 1 (OPA1) inhibition, mitochondrial function and morphology measurements, micro-RNA (miRNA) profiling and formal epistatic analyses to address the role of OPA1 in TNBC proliferation, migration, and invasion in vitro and in vivo.\nResults: We identified a signature of OPA1 upregulation in breast cancer that correlates with worse prognosis. Accordingly, OPA1 inhibition could reduce breast cancer cells proliferation, migration, and invasion in vitro and in vivo. Mechanistically, while OPA1 silencing did not reduce mitochondrial respiration, it increased levels of miRNAs of the 148/152 family known to inhibit tumor growth and invasiveness. Indeed, these miRNAs were epistatic to OPA1 in the regulation of TNBC cells growth and invasiveness.\nConclusions: Our data show that targeted inhibition of the mitochondrial fusion protein OPA1 curtails TNBC growth and nominate OPA1 as a druggable target in TNBC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"},{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"17569966","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1186/s13046-022-02304-6"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/s13046-022-02304-6","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"400056"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zamberlan, Margherita","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Boeckx, Amandine","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Muller, Florian","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Vinelli, Federica","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ek, Olivier","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Vianello, Caterina","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Coart, Emeline","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"柴田, 桂太朗","creatorNameLang":"ja"},{"creatorName":"シバタ, ケイタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Shibata, Keitaro","creatorNameLang":"en"}],"familyNames":[{"familyName":"柴田","familyNameLang":"ja"},{"familyName":"シバタ","familyNameLang":"ja-Kana"},{"familyName":"Shibata","familyNameLang":"en"}],"givenNames":[{"givenName":"桂太朗","givenNameLang":"ja"},{"givenName":"ケイタロウ","givenNameLang":"ja-Kana"},{"givenName":"Keitaro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1413","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"372290/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/372290/profile-ja.html"}]},{"creatorNames":[{"creatorName":"Christian, Aurélie","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Grespi, Francesca","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Giacomello, Marta","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Struman, Ingrid","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Scorrano, Luca","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Herkenne, Stéphanie","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-08-31"}],"displaytype":"detail","filename":"jeccr_41_95.pdf","filesize":[{"value":"8.55 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011213/files/jeccr_41_95.pdf"},"version_id":"b6edd18b-ecfa-4a31-b24e-fea08906793d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-08-31"},"publish_date":"2023-08-31","publish_status":"0","recid":"2011213","relation_version_is_last":true,"title":["Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-03T00:02:39.761950+00:00"}