{"created":"2024-12-12T10:09:22.837192+00:00","id":2011308,"links":{},"metadata":{"_buckets":{"deposit":"bcdaa977-64d2-4f04-b35a-655da2236dac"},"_deposit":{"created_by":7,"id":"2011308","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011308"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011308","sets":["1713853213384:1713853295607"]},"author_link":["1207","306"],"control_number":"2011308","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Clozapine and Antipsychotic Monotherapy","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-20","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"826","bibliographicPageStart":"818","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"International Journal of Neuropsychopharmacology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Although clozapine is effective for treatment-resistant schizophrenia (TRS), the rate of clozapine prescription is still low. Whereas antipsychotic monotherapy is recommended in clinical practice guidelines, the rate of antipsychotic polypharmacy is still high. There is little evidence on whether a clozapine prescription influences changes in the rate of monotherapy and polypharmacy, including antipsychotics and other psychotropics. We therefore hypothesized that the rate of antipsychotic monotherapy in patients with TRS who were prescribed clozapine would be higher than that in patients with schizophrenia who were not prescribed clozapine.\nMethods: We assessed 8306 patients with schizophrenia nationwide from 178 institutions in Japan from 2016 to 2019. We analyzed the psychotropic prescription data at discharge in patients diagnosed with TRS and with no description of TRS (ND-TRS) based on the diagnosis listed in the discharge summary.\nResults: The rate of antipsychotic monotherapy in the TRS with clozapine group (91.3%) was significantly higher than that in the TRS without clozapine group (45.9%; P < 2.0 × 10−16) and the ND-TRS without clozapine group (54.7%; P < 2.0 × 10−16). The rate of antipsychotic monotherapy without any other concomitant psychotropics in the TRS with clozapine group (26.5%) was significantly higher than that in the TRS without clozapine group (12.6%; P = 1.1 × 10−6) and the ND-TRS without clozapine group (17.0%; P = 5.9 × 10−6).\nConclusions: Clozapine prescription could be associated with a high rate of antipsychotic monotherapy. Patients will benefit from the correct diagnosis of TRS and thus from proper clozapine prescription.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14611457","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"14695111","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11545519","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1093/ijnp/pyac036"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1093/ijnp/pyac036","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"396294"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"オチ, シンイチロウ","creatorNameLang":"ja"},{"creatorName":"オチ, シンイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Ochi, Shinichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タガタ, ヒロミ","creatorNameLang":"ja"},{"creatorName":"タガタ, ヒロミ","creatorNameLang":"ja-Kana"},{"creatorName":"Tagata, Hiromi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハセガワ, ナオミ","creatorNameLang":"ja"},{"creatorName":"ハセガワ, ナオミ","creatorNameLang":"ja-Kana"},{"creatorName":"Hasegawa, Naomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤスイ フルコオリ, ノリオ","creatorNameLang":"ja"},{"creatorName":"ヤスイ フルコオリ, ノリオ","creatorNameLang":"ja-Kana"},{"creatorName":"Yasui-Furukori, Norio","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"伊賀, 淳一","creatorNameLang":"ja"},{"creatorName":"イガ, ジュンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Iga, Junichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"伊賀","familyNameLang":"ja"},{"familyName":"イガ","familyNameLang":"ja-Kana"},{"familyName":"Iga","familyNameLang":"en"}],"givenNames":[{"givenName":"淳一","givenNameLang":"ja"},{"givenName":"ジュンイチ","givenNameLang":"ja-Kana"},{"givenName":"Junichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1207","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70363140","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70363140"}]},{"creatorNames":[{"creatorName":"カシワギ, ヒロコ","creatorNameLang":"ja"},{"creatorName":"カシワギ, ヒロコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kashiwagi, Hiroko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コダカ, フミトシ","creatorNameLang":"ja"},{"creatorName":"コダカ, フミトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kodaka, Fumitoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コマツ, ヒロシ","creatorNameLang":"ja"},{"creatorName":"コマツ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Komatsu, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ツボイ, タカシ","creatorNameLang":"ja"},{"creatorName":"ツボイ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuboi, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"トクタニ, アキラ","creatorNameLang":"ja"},{"creatorName":"トクタニ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Tokutani, Akira","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"沼田, 周助","creatorNameLang":"ja"},{"creatorName":"ヌマタ, シュウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Numata, Shusuke","creatorNameLang":"en"}],"familyNames":[{"familyName":"沼田","familyNameLang":"ja"},{"familyName":"ヌマタ","familyNameLang":"ja-Kana"},{"familyName":"Numata","familyNameLang":"en"}],"givenNames":[{"givenName":"周助","givenNameLang":"ja"},{"givenName":"シュウスケ","givenNameLang":"ja-Kana"},{"givenName":"Shusuke","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"306","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"172447/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/172447/profile-ja.html"},{"nameIdentifier":"10403726","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10403726"}]},{"creatorNames":[{"creatorName":"イチハシ, カヨ","creatorNameLang":"ja"},{"creatorName":"イチハシ, カヨ","creatorNameLang":"ja-Kana"},{"creatorName":"Ichihashi, Kayo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オニツカ, トシアキ","creatorNameLang":"ja"},{"creatorName":"オニツカ, トシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Onitsuka, Toshiaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ムラオカ, ヒロユキ","creatorNameLang":"ja"},{"creatorName":"ムラオカ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Muraoka, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イイダ, ヒトシ","creatorNameLang":"ja"},{"creatorName":"イイダ, ヒトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Iida, Hitoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オオイ, カズタカ","creatorNameLang":"ja"},{"creatorName":"オオイ, カズタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohi, Kazutaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アタケ, キヨカズ","creatorNameLang":"ja"},{"creatorName":"アタケ, キヨカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Atake, Kiyokazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キシモト, タイシロウ","creatorNameLang":"ja"},{"creatorName":"キシモト, タイシロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kishimoto, Taishiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ホリ, ヒカル","creatorNameLang":"ja"},{"creatorName":"ホリ, ヒカル","creatorNameLang":"ja-Kana"},{"creatorName":"Hori, Hikaru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカエス, ヨシカズ","creatorNameLang":"ja"},{"creatorName":"タカエス, ヨシカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Takaesu, Yoshikazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケシマ, マサヒロ","creatorNameLang":"ja"},{"creatorName":"タケシマ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeshima, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウサミ, マサヒデ","creatorNameLang":"ja"},{"creatorName":"ウサミ, マサヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Usami, Masahide","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マキノダン, マナブ","creatorNameLang":"ja"},{"creatorName":"マキノダン, マナブ","creatorNameLang":"ja-Kana"},{"creatorName":"Makinodan, Manabu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハシモト, ナオキ","creatorNameLang":"ja"},{"creatorName":"ハシモト, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Hashimoto, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フジモト, ミチコ","creatorNameLang":"ja"},{"creatorName":"フジモト, ミチコ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujimoto, Michiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フリハタ, リュウジ","creatorNameLang":"ja"},{"creatorName":"フリハタ, リュウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Furihata, Ryuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナガサワ, タツヤ","creatorNameLang":"ja"},{"creatorName":"ナガサワ, タツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Nagasawa, Tatsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマダ, ヒサシ","creatorNameLang":"ja"},{"creatorName":"ヤマダ, ヒサシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Hisashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツモト, ジュンヤ","creatorNameLang":"ja"},{"creatorName":"マツモト, ジュンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsumoto, Junya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミウラ, ケンイチロウ","creatorNameLang":"ja"},{"creatorName":"ミウラ, ケンイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Miura, Kenichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キド, ミキオ","creatorNameLang":"ja"},{"creatorName":"キド, ミキオ","creatorNameLang":"ja-Kana"},{"creatorName":"Kido, Mikio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒシモト, アキトヨ","creatorNameLang":"ja"},{"creatorName":"ヒシモト, アキトヨ","creatorNameLang":"ja-Kana"},{"creatorName":"Hishimoto, Akitoyo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"上野, 修一","creatorNameLang":"ja"},{"creatorName":"ウエノ, シュウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Ueno, Shu-ichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ワタナベ, コウイチロウ","creatorNameLang":"ja"},{"creatorName":"ワタナベ, コウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Koichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イナダ, ケン","creatorNameLang":"ja"},{"creatorName":"イナダ, ケン","creatorNameLang":"ja-Kana"},{"creatorName":"Inada, Ken","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハシモト, リョウタ","creatorNameLang":"ja"},{"creatorName":"ハシモト, リョウタ","creatorNameLang":"ja-Kana"},{"creatorName":"Hashimoto, Ryota","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-20"}],"displaytype":"detail","filename":"ijnp_25_10_818.pdf","filesize":[{"value":"287 KB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011308/files/ijnp_25_10_818.pdf"},"version_id":"72e808ae-9e67-47db-af34-f489ce5c1032"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Treatment-resistant schizophrenia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lithium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"polypharmacy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"guideline","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"EGUIDE","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Clozapine Treatment Is Associated With Higher Prescription Rate of Antipsychotic Monotherapy and Lower Prescription Rate of Other Concomitant Psychotropics : A Real-World Nationwide Study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Clozapine Treatment Is Associated With Higher Prescription Rate of Antipsychotic Monotherapy and Lower Prescription Rate of Other Concomitant Psychotropics : A Real-World Nationwide Study","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-20"},"publish_date":"2023-12-20","publish_status":"0","recid":"2011308","relation_version_is_last":true,"title":["Clozapine Treatment Is Associated With Higher Prescription Rate of Antipsychotic Monotherapy and Lower Prescription Rate of Other Concomitant Psychotropics : A Real-World Nationwide Study"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-31T06:11:33.128981+00:00"}