{"created":"2024-12-12T10:15:55.521414+00:00","id":2011377,"links":{},"metadata":{"_buckets":{"deposit":"fb4c82ef-86ee-42fa-b78d-8b4ff7835ac3"},"_deposit":{"created_by":7,"id":"2011377","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011377"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011377","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["1434","1689","859","589"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"神経障害性疼痛モデル動物におけるトラニラストの鎮痛効果とテトラヒドロビオプテリン合成制御の役割","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"5878","bibliographicVolumeNumber":"23","bibliographic_titles":[{"bibliographic_title":"International Journal of Molecular Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Trigeminal neuralgia is unilateral, lancinating, episodic pain that can be provoked by routine activities. Anticonvulsants, such as carbamazepine, are the drugs of choice; however, these possess side-effects. Microvascular decompression is the most effective surgical technique with a higher success rate, although occasionally causes adverse effects. The potential treatment for this type of pain remains unmet. Increased tetrahydrobiopterin (BH4) levels have been reported in association with axonal injury. This study aimed to evaluate the effect of tranilast on relieving neuropathic pain in animal models and analyze the changes in BH4 synthesis. Neuropathic pain was induced via infraorbital nerve constriction. Tranilast, carbamazepine, or saline was injected intraperitoneally to assess the rat’s post-intervention pain response. In the von Frey’s test, the tranilast and carbamazepine groups showed significant changes in the head withdrawal threshold in the ipsilateral whisker pad area. The motor coordination test showed no changes in the tranilast group, whereas the carbamazepine group showed decreased performance, indicating impaired motor coordination. Trigeminal ganglion tissues were used for the PCR array analysis of genes that regulate the BH4 pathway. Downregulation of the sepiapterin reductase (Spr) and aldoketo reductase (Akr) genes after tranilast injection was observed compared to the pain model. These findings suggest that tranilast effectively treats neuropathic pain.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14220067","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3750号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-09-20"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Swarna lakshmi Ramanの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院口腔科学研究科（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第500号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3390/ijms23115878"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3390/ijms23115878","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"385556"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ラマン, スワルナ ラクシュミ","creatorNameLang":"ja"},{"creatorName":"ラマン, スワルナ ラクシュミ","creatorNameLang":"ja-Kana"},{"creatorName":"Raman, Swarna Lakshmi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Waskitho, Arief","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Raju, Resmi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岩浅, 匠真","creatorNameLang":"ja"},{"creatorName":"イワサ, タクマ","creatorNameLang":"ja-Kana"},{"creatorName":"Iwasa, Takuma","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"生田目, 大介","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1434","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大倉, 一夫","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1689","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大島, 正充","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松香, 芳三","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"589","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-10-25"}],"displaytype":"detail","filename":"k3750_abstract.pdf","filesize":[{"value":"80.9 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2011377/files/k3750_abstract.pdf"},"version_id":"90240f5e-9de2-468b-9b82-6e9168abe8e5"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-10-25"}],"displaytype":"detail","filename":"k3750_review.pdf","filesize":[{"value":"41.2 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2011377/files/k3750_review.pdf"},"version_id":"ffc819a7-ad3d-4f5e-bf4b-e471569a3416"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-10-25"}],"displaytype":"detail","filename":"k3750_fulltext.pdf","filesize":[{"value":"4.09 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011377/files/k3750_fulltext.pdf"},"version_id":"39965611-0c14-4db1-89c5-3339fed4c7c6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"orofacial pain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neuropathic pain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"infraorbital nerve constriction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nerve injury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tetrahydrobiopterin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"tranilast","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"trigeminal ganglion","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Analgesic Effect of Tranilast in an Animal Model of Neuropathic Pain and Its Role in the Regulation of Tetrahydrobiopterin Synthesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Analgesic Effect of Tranilast in an Animal Model of Neuropathic Pain and Its Role in the Regulation of Tetrahydrobiopterin Synthesis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268556148"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-10-25"},"publish_date":"2023-10-25","publish_status":"0","recid":"2011377","relation_version_is_last":true,"title":["Analgesic Effect of Tranilast in an Animal Model of Neuropathic Pain and Its Role in the Regulation of Tetrahydrobiopterin Synthesis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2024-12-12T10:16:06.280591+00:00"}