{"created":"2025-01-09T12:18:20.106266+00:00","id":2011484,"links":{},"metadata":{"_buckets":{"deposit":"f29dda2d-57ac-4c4e-89af-d8642fe97de5"},"_deposit":{"created_by":7,"id":"2011484","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011484"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011484","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["1418","521","1496","1636","427","943","818","1005","523","228"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"腎血流量を低下させる薬剤を含む複数の腎毒性を有する薬の併用はバンコマイシン関連腎障害を引き起こす : 2つのリアルワールドデータベースを組み合わせた後方視的研究","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"Nephrotoxicity with VCM and Nephrotoxins","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"605","bibliographicPageStart":"595","bibliographicVolumeNumber":"77","bibliographic_titles":[{"bibliographic_title":"Acta Medica Okayama","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"There is a growing concern about the relationship between vancomycin-associated nephrotoxicity (VAN) and concomitant use of nephrotoxins. We examined this relationship by combined retrospective analyses of two real-world databases. Initially, the FDA Adverse Event Reporting System (FAERS) was analyzed for the effects of concomitant use of one or more nephrotoxins on VAN and the types of combinations of nephrotoxins that exacerbate VAN. Next, electronic medical records (EMRs) of patients who received vancomycin (VCM) at Tokushima University Hospital between January 2006 and March 2019 were examined to confirm the FAERS analysis. An elevated reporting odds ratio (ROR) was observed with increases in the number of nephrotoxins administered (VCM + one nephrotoxin, adjusted ROR (95% confidence interval [CI]) 1.67 [1.51–1.85]; VCM + ≥ 2 nephrotoxins, adjusted ROR [95% CI] 1.54 [1.37–1.73]) in FAERS. EMRs analysis showed that the number of nephrotoxins was associated with higher incidences of VAN [odds ratio: 1.99; 95% CI: 1.42–2.78]. Overall, concomitant use of nephrotoxins was associated with an increased incidence of VAN, especially when at least one of those nephrotoxins was a renal hypoperfusion medication (furosemide, non-steroidal anti-inflammatory drugs, and vasopressors). The concomitant use of multiple nephrotoxins, especially including renal hypoperfusion medication, should be avoided to prevent VAN.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Okayama University Medical School","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"CopyrightⒸ 2023 by Okayama University Medical School","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"0386300X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA00508441","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3761号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-10-26"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は,著者Takashi Bandoの学位論文として提出され,学位審査・授与の対象となっている。\n利用は著作権の範囲内に限られる。\n学位授与者所属 : 徳島大学大学院医学研究科(医学専攻)"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1586号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.18926/AMO/66151"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://ousar.lib.okayama-u.ac.jp/en/journal/amo/77/6/article/66151","subitem_relation_type_select":"URI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"407553"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂東, 貴司","creatorNameLang":"ja"},{"creatorName":"バンドウ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Bando, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"中馬, 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Databases","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-01-15"},"publish_date":"2024-01-15","publish_status":"0","recid":"2011484","relation_version_is_last":true,"title":["Concomitant Use of Multiple Nephrotoxins Including Renal Hypoperfusion Medications Causes Vancomycin-Associated Nephrotoxicity : Combined Retrospective Analyses of Two Real-World Databases"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-28T04:57:20.429014+00:00"}