| Item type |
文献 / Documents(1) |
| 公開日 |
2024-01-22 |
| アクセス権 |
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アクセス権 |
open access |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.4049/immunohorizons.2200103 |
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関連名称 |
10.4049/immunohorizons.2200103 |
| 出版タイプ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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|
タイトル |
Dispensable Role of Aire in CD11c+ Conventional Dendritic Cells for Antigen Presentation and Shaping the Transcriptome |
| タイトル別表記 |
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その他のタイトル |
DISPENSABLE ROLE OF AIRE IN cDCs |
| 著者 |
宮澤, 龍一郎
ナガオ, ジュンイチ
アリタ モリオカ, ケンイチ
| ja |
アリタ モリオカ, ケンイチ
|
| ja-Kana |
アリタ モリオカ, ケンイチ
|
| en |
Arita-Morioka, Ken-ichi
|
Search repository
松本, 穣
森本, 純子
ヨシダ, マサキ
尾矢, 剛志
常山, 幸一
ヨシダ, ヒデユキ
タナカ, ヨシヒコ
松本, 満
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| 抄録 |
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内容記述 |
Aire, the defect of which is responsible for the development of autoimmunity, is predominantly expressed in medullary thymic epithelial cells, and it controls a wide variety of genes, including those of tissue-restricted Ags, for establishing thymic tolerance. Aire is also expressed from APCs in the periphery, called extrathymic Aire-expressing cells (eTACs), and their complementing role to thymic tolerance has been suggested. eTACs are composed of two distinct classes of APCs, conventional dendritic cell (cDC)–type and group 3 innate lymphoid cell (ILC3)-like–type expressing retinoic acid receptor–related orphan receptor γt (RORγt). Although the essential role of Aire in the latter in the Th17-mediated immune response against Candida albicans has been reported, the role of Aire in the cDC-type eTACs for this action has not been examined. Furthermore, the significance of Aire in the production of the transcriptome of the cDC-type eTACs remains unknown. We have approached these issues using a high-fidelity Aire-reporter mouse strain. We found that although the cDC-type eTACs dominated ILC3-like–type eTACs in number and they served as efficient APCs for the immune response against an exogenous Ag as well as for the C. albicans–specific Th17 immune response, loss of Aire in cDC-type eTACs showed no clear effect on these functions. Furthermore, loss of Aire showed no major impact on the transcriptome from cDC-type eTACs. These results suggested that Aire in cDC-type eTACs may not have a cell-intrinsic role in the immune response in contrast to the role of Aire in ILC3-like–type eTACs. |
| 書誌情報 |
en : ImmunoHorizons
巻 7,
号 1,
p. 140-158,
発行日 2023-01-25
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| 収録物ID |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
25737732 |
| 出版者 |
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出版者 |
The American Association of Immunologists |
| 権利情報 |
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|
権利情報 |
This article is distributed under the terms of the CC BY-NC-ND 4.0 Unported license. |
| EID |
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|
識別子 |
393828 |
| 言語 |
|
|
言語 |
eng |
immuno_7_1_140.pdf (3.61 MB)
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