{"created":"2025-01-14T00:32:46.618850+00:00","id":2011536,"links":{},"metadata":{"_buckets":{"deposit":"642a25b5-071d-4751-9983-de325a0e62f0"},"_deposit":{"created_by":7,"id":"2011536","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011536"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011536","sets":["1713829974766:1713854681789:1716364512866:1716365091387","1713853213384:1713853295607"]},"author_link":["1426","732","415"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Urinary adiponectin as a biomarker for DKD","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3-4","bibliographicPageEnd":"470","bibliographicPageStart":"464","bibliographicVolumeNumber":"70","bibliographic_titles":[{"bibliographic_title":"The Journal of Medical Investigation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We previously developed two immune complex transfer enzyme immunoassays (ICT-EIA) to measure total adiponectin (T-AN) and high molecular weight adiponectin (H-AN) in urine and have verified their usefulness as biomarkers for diabetic kidney disease. In this study, we developed T-AN and H-AN assays using the sandwich EIA (Sand-EIA). The reactivities of Sand-EIAs were compared with ICT-EIAs by measuring size exclusion chromatography (SEC) fractions of urine and adiponectin standard. As a result, ICT-EIAs showed higher macromolecular specificity. We then analyzed the molecular profile of adiponectin in the urine of 5 patients with different eGFR stages by measuring SEC fractions of urine. The results showed that smaller adiponectin correlated relatively well with eGFR stage. Finally, because SEC is time-consuming, we investigated that the ratio of T-ANs by Sand-EIA and ICT-EIA could be a good indicator of the monomer adiponectin. The ratio was evaluated using 77 urine samples from patients with diabetes and showed a significant decrease at an earlier stage compared with other biomarkers. In conclusion, we demonstrated a new index to estimate monomer adiponectin in urine by using Sand-EIA and ICT-EIA, and urinary monomer adiponectin can be a good early indicator of deterioration of renal function in diabetic patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Tokushima University Faculty of 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immunoassay","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Urinary adiponectin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Kidney disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Biomarker","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Molecular composition of adiponectin in urine is a useful biomarker for detecting early stage of diabetic kidney disease","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Molecular composition of adiponectin in urine is a useful biomarker for detecting early stage of diabetic kidney 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