{"created":"2025-01-14T00:40:22.646210+00:00","id":2011613,"links":{},"metadata":{"_buckets":{"deposit":"cfc78380-2cc4-46d3-b794-661741bf2a01"},"_deposit":{"created_by":7,"id":"2011613","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011613"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011613","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["116","837","383","545","975","897"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"脳梗塞モデルラットにおける虚血後の時期依存的な抗炎症性M2マクロファージ活性化変調の役割","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-12-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"541","bibliographicPageStart":"531","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Journal of Cerebral Blood Flow & Metabolism","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cerebral ischemia triggers inflammatory changes, and early complications and unfavorable outcomes of endovascular thrombectomy for brain occlusion promote the recruitment of various cell types to the ischemic area. Although anti-inflammatory M2-type macrophages are thought to exert protective effects against cerebral ischemia, little has been clarified regarding the significance of post-ischemic phase-dependent modulation of M2-type macrophages. To test our hypothesis that post-ischemic phase-dependent modulation of macrophages represents a potential therapy against ischemic brain damage, the effects on rats of an M2-type macrophage-specific activator, Gc-protein macrophage-activating factor (GcMAF), were compared with vehicle-treated control rats in the acute (day 0–6) or subacute (day 7–13) phase after ischemia induction. Acute-phase GcMAF treatment augmented both anti-inflammatory CD163+M2-type- and pro-inflammatory CD16+ M1-type macrophages, resulting in no beneficial effects. Conversely, subacute-phase GcMAF injection increased only CD163+ M2-type macrophages accompanied by elevated mRNA levels of arginase-1 and interleukin-4. M2-type macrophages co-localized with CD36+ phagocytic cells led to clearance of the infarct area, which were abrogated by clodronate-liposomes. Expression of survival-related molecules on day 28 at the infarct border was augmented by GcMAF. These data provide new and important insights into the significance of M2-type macrophage-specific activation as post-ischemic phase-dependent therapy.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Society for Cerebral Blood Flow and Metabolism","subitem_publisher_language":"en"},{"subitem_publisher":"Sage","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"Kurashiki Y, Kagusa H, Yagi K, et al. Role of post-ischemic phase-dependent modulation of anti-inflammatory M2-type macrophages against rat brain damage. Journal of Cerebral Blood Flow & Metabolism. 2023;43(4):531-541. Copyright © 2022 The Author(s). doi:10.1177/0271678X221147090","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"15597016","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"0271678X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12510484","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA10458430","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3766号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-12-28"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Yoshitaka Kurashikiの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1591号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1177/0271678X221147090"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1177/0271678X221147090","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"393891"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"倉敷, 佳孝","creatorNameLang":"ja"},{"creatorName":"クラシキ, ヨシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Kurashiki, Yoshitaka","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"鹿草, 宏","creatorNameLang":"ja"},{"creatorName":"カグサ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Kagusa, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"鹿草","familyNameLang":"ja"},{"familyName":"カグサ","familyNameLang":"ja-Kana"},{"familyName":"Kagusa","familyNameLang":"en"}],"givenNames":[{"givenName":"宏","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"},{"givenName":"Hiroshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"975","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"350239/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/350239/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"八木, 謙次","creatorNameLang":"ja"},{"creatorName":"ヤギ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Yagi, Kenji","creatorNameLang":"en"}],"familyNames":[{"familyName":"八木","familyNameLang":"ja"},{"familyName":"ヤギ","familyNameLang":"ja-Kana"},{"familyName":"Yagi","familyNameLang":"en"}],"givenNames":[{"givenName":"謙次","givenNameLang":"ja"},{"givenName":"ケンジ","givenNameLang":"ja-Kana"},{"givenName":"Kenji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"383","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80551837","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80551837"}]},{"creatorNames":[{"creatorName":"木内, 智也","creatorNameLang":"ja"},{"creatorName":"キノウチ, トモヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Kinouchi, Tomoya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"住吉, 学","creatorNameLang":"ja"},{"creatorName":"スミヨシ, マナブ","creatorNameLang":"ja-Kana"},{"creatorName":"Sumiyoshi, Manabu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"宮本, 健志","creatorNameLang":"ja"},{"creatorName":"ミヤモト, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyamoto, Takeshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"宮本","familyNameLang":"ja"},{"familyName":"ミヤモト","familyNameLang":"ja-Kana"},{"familyName":"Miyamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"健志","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"Takeshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"837","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"312493/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/312493/profile-ja.html"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"島田, 健司","creatorNameLang":"ja"},{"creatorName":"シマダ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimada, Kenji","creatorNameLang":"en"}],"familyNames":[{"familyName":"島田","familyNameLang":"ja"},{"familyName":"シマダ","familyNameLang":"ja-Kana"},{"familyName":"Shimada","familyNameLang":"en"}],"givenNames":[{"givenName":"健司","givenNameLang":"ja"},{"givenName":"ケンジ","givenNameLang":"ja-Kana"},{"givenName":"Kenji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"545","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"241625/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/241625/profile-ja.html"}]},{"creatorNames":[{"creatorName":"キタザト, ケイコ","creatorNameLang":"ja"},{"creatorName":"キタザト, ケイコ","creatorNameLang":"ja-Kana"},{"creatorName":"Kitazato, Keiko T","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"宇都, 義浩","creatorNameLang":"ja"},{"creatorName":"ウト, ヨシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Uto, Yoshihiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"宇都","familyNameLang":"ja"},{"familyName":"ウト","familyNameLang":"ja-Kana"},{"familyName":"Uto","familyNameLang":"en"}],"givenNames":[{"givenName":"義浩","givenNameLang":"ja"},{"givenName":"ヨシヒロ","givenNameLang":"ja-Kana"},{"givenName":"Yoshihiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"116","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10780/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/10780/profile-ja.html"},{"nameIdentifier":"20304553","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20304553"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"高木, 康志","creatorNameLang":"ja"},{"creatorName":"タカギ, ヤスシ","creatorNameLang":"ja-Kana"},{"creatorName":"Takagi, Yasushi","creatorNameLang":"en"}],"familyNames":[{"familyName":"高木","familyNameLang":"ja"},{"familyName":"タカギ","familyNameLang":"ja-Kana"},{"familyName":"Takagi","familyNameLang":"en"}],"givenNames":[{"givenName":"康志","givenNameLang":"ja"},{"givenName":"ヤスシ","givenNameLang":"ja-Kana"},{"givenName":"Yasushi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"897","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"334002/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/334002/profile-ja.html"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-14"}],"displaytype":"detail","filename":"k3766_abstract.pdf","filesize":[{"value":"235 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2011613/files/k3766_abstract.pdf"},"version_id":"d6fcd745-a1d9-418a-86bf-b88866394dcf"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-14"}],"displaytype":"detail","filename":"k3766_review.pdf","filesize":[{"value":"120 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2011613/files/k3766_review.pdf"},"version_id":"d8885848-22bd-4617-b01e-748997388b19"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-14"}],"displaytype":"detail","filename":"k3766_fulltext.pdf","filesize":[{"value":"565 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011613/files/k3766_fulltext.pdf"},"version_id":"54899b20-6e26-4fb0-aa7b-217d2f12808d"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-14"}],"displaytype":"detail","filename":"k3766_figure.pdf","filesize":[{"value":"1.35 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2011613/files/k3766_figure.pdf"},"version_id":"02525e22-e184-457c-9717-fdfe3dfe9783"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Arginase-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cerebral ischemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage modulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"post-ischemic phase","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Role of post-ischemic phase-dependent modulation of anti-inflammatory M2-type macrophages against rat brain damage","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Role of post-ischemic phase-dependent modulation of anti-inflammatory M2-type macrophages against rat brain damage","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-03-14"},"publish_date":"2024-03-14","publish_status":"0","recid":"2011613","relation_version_is_last":true,"title":["Role of post-ischemic phase-dependent modulation of anti-inflammatory M2-type macrophages against rat brain damage"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-13T04:50:30.146692+00:00"}