{"created":"2025-01-14T00:40:36.506144+00:00","id":2011615,"links":{},"metadata":{"_buckets":{"deposit":"84c28c8c-0a87-4438-8870-f11992837c23"},"_deposit":{"created_by":7,"id":"2011615","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011615"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011615","sets":["1713853213384:1713853295607"]},"author_link":["815","199","1542"],"control_number":"2011615","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-07-24","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"3147","bibliographicPageStart":"3139","bibliographicVolumeNumber":"149","bibliographic_titles":[{"bibliographic_title":"Journal of Cancer Research and Clinical Oncology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Immune checkpoint inhibitors (ICI) are a promising treatment, but may cause hyperprogressive disease and early death. The present study investigated early mortality factors in ICI monotherapy for lung cancer.\nPatients and methods: We retrospectively reviewed all patients diagnosed with advanced or metastatic non-small cell lung cancer (NSCLC) and treated with ICI monotherapy (nivolumab, pembrolizumab, and atezolizumab) between March 2016 and August 2021 at National Hospital Organization Kochi Hospital and Tokushima University. Early death was defined as patients who died within 60 days of ICI treatment.\nResults: A total of 166 patients were included. The majority of patients (87%) had an Eastern cooperative oncology group (ECOG) Performance status (PS) of 0/1. There were 21 early deaths. Significant differences were observed in ECOG PS, the histological type, liver metastasis, tumor size, the white blood cell count, neutrophils (%), lymphocytes (%), the neutrophilto-lymphocyte ratio in serum (sNLR), C-reactive protein (CRP), and albumin between the groups with or without early death. Univariate logistic regression analyses identified ECOG PS score ≥ 2, liver metastasis, tumor size ≥ 5 cm, neutrophils ≥ 69%, lymphocytes < 22%, sNLR ≥ 4, CRP ≥ 1 mg/dl, and albumin < 3.58 g/dl as significant risk factors for early death. A multivariate logistic regression analysis revealed that liver metastasis (Odds ratio [OR], 10.3; p = 0.008), ECOG PS score ≥ 2 (OR, 8.0; p = 0.007), and a smoking history (OR, 0.1; p = 0.03) were significant risk factors for early death.\nConclusion: Liver metastases, ECOG PS score ≥ 2, and a non-smoking history are early mortality factors in ICI monotherapy for advanced or metastatic NSCLC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer-Verlag","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"14321335","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"01715216","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA0025708X","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1007/s00432-022-04215-7"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1007/s00432-022-04215-7","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"397299"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"タケウチ, エイジ","creatorNameLang":"ja"},{"creatorName":"タケウチ, エイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeuchi, Eiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コンドウ, ケンスケ","creatorNameLang":"ja"},{"creatorName":"コンドウ, ケンスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Kensuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オカノ, ヨシオ","creatorNameLang":"ja"},{"creatorName":"オカノ, ヨシオ","creatorNameLang":"ja-Kana"},{"creatorName":"Okano, Yoshio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"國重, 道大","creatorNameLang":"ja"},{"creatorName":"クニシゲ, ミチヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Kunishige, Michihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コンドウ, ヨシヒロ","creatorNameLang":"ja"},{"creatorName":"コンドウ, ヨシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Yoshihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カドタ, ナオキ","creatorNameLang":"ja"},{"creatorName":"カドタ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kadota, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マチダ, ヒサノリ","creatorNameLang":"ja"},{"creatorName":"マチダ, ヒサノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Machida, Hisanori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハタケヤマ, ノブオ","creatorNameLang":"ja"},{"creatorName":"ハタケヤマ, 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Hiroshi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"篠原, 勉","creatorNameLang":"ja"},{"creatorName":"シノハラ, ツトム","creatorNameLang":"ja-Kana"},{"creatorName":"Shinohara, Tsutomu","creatorNameLang":"en"}],"familyNames":[{"familyName":"篠原","familyNameLang":"ja"},{"familyName":"シノハラ","familyNameLang":"ja-Kana"},{"familyName":"Shinohara","familyNameLang":"en"}],"givenNames":[{"givenName":"勉","givenNameLang":"ja"},{"givenName":"ツトム","givenNameLang":"ja-Kana"},{"givenName":"Tsutomu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"199","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"124424/profile-ja.html","nameIdentifierScheme":"徳島大学 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Yasuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"西岡","familyNameLang":"ja"},{"familyName":"ニシオカ","familyNameLang":"ja-Kana"},{"familyName":"Nishioka","familyNameLang":"en"}],"givenNames":[{"givenName":"安彦","givenNameLang":"ja"},{"givenName":"ヤスヒコ","givenNameLang":"ja-Kana"},{"givenName":"Yasuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1542","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60062/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60062/profile-ja.html"},{"nameIdentifier":"70274199","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70274199"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-02-01"}],"displaytype":"detail","filename":"JofCRCO_149_3139.pdf","filesize":[{"value":"794 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cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Monotherapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Early mortality factors in immune checkpoint inhibitor monotherapy for advanced or metastatic non‑small cell lung cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Early mortality factors in immune checkpoint inhibitor monotherapy for advanced or metastatic non‑small cell lung cancer","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-02-01"},"publish_date":"2024-02-01","publish_status":"0","recid":"2011615","relation_version_is_last":true,"title":["Early mortality factors in immune checkpoint inhibitor monotherapy for advanced or metastatic non‑small cell lung cancer"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:22:40.764795+00:00"}