{"created":"2025-01-14T00:44:17.803272+00:00","id":2011654,"links":{},"metadata":{"_buckets":{"deposit":"1d612625-5b81-465a-ae58-f7b97332802c"},"_deposit":{"created_by":7,"id":"2011654","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011654"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011654","sets":["1713853213384:1713853295607"]},"author_link":["614"],"control_number":"2011654","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-12-16","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageStart":"2495","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Microorganisms","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Helicobacter pylori infection is an important risk factor for developing gastric cancer. However, only a few H. pylori-infected people develop gastric cancer. Thus, other risk factors aside from H. pylori infection may be involved in gastric cancer development. This study aimed to investigate whether the nitrate-reducing bacteria isolated from patients with atrophic gastritis caused by H. pylori infection are risk factors for developing atrophic gastritis and gastric neoplasia. Nitrate-reducing bacteria were isolated from patients with atrophic gastritis caused by H. pylori infection. Among the isolated bacteria, Actinomyces oris, Actinomyces odontolyticus, Rothia dentocariosa, and Rothia mucilaginosa were used in the subsequent experiments. Cytokine inducibility was evaluated in monocytic cells, and mitogen-activated protein kinase (MAPK) activity and cell cycle were assessed in the gastric epithelial cells. The cytotoxicities and neutrophil-inducing abilities of the Actinomyces and Rothia species were enhanced when cocultured with H. pylori. Th1/Th2-related cytokines were also expressed, but their expression levels differed depending on the bacterial species. Moreover, H. pylori and Actinomyces activated MAPK (ERK and p38) and affected cell cycle progression. Some nitrate-reducing bacteria cocultured with H. pylori may promote inflammation and atrophy by inducing cytokine production. In addition, the MAPK activation and cell cycle progression caused by these bacteria can contribute to gastric cancer development.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20762607","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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ショウタロウ","creatorNameLang":"ja"},{"creatorName":"オカノウエ, ショウタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Okanoue, Shyoutarou","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オカダ, ヒロユキ","creatorNameLang":"ja"},{"creatorName":"オカダ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Okada, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ゴトウ, カズヨシ","creatorNameLang":"ja"},{"creatorName":"ゴトウ, カズヨシ","creatorNameLang":"ja-Kana"},{"creatorName":"Gotoh, Kazuyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツシタ, オサム","creatorNameLang":"ja"},{"creatorName":"マツシタ, オサム","creatorNameLang":"ja-Kana"},{"creatorName":"Matsushita, Osamu","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"渡辺, 朱理","creatorNameLang":"ja"},{"creatorName":"ワタナベ, アカリ","creatorNameLang":"ja-Kana"},{"creatorName":"Watanabe, Akari","creatorNameLang":"en"}],"familyNames":[{"familyName":"渡辺","familyNameLang":"ja"},{"familyName":"ワタナベ","familyNameLang":"ja-Kana"},{"familyName":"Watanabe","familyNameLang":"en"}],"givenNames":[{"givenName":"朱理","givenNameLang":"ja"},{"givenName":"アカリ","givenNameLang":"ja-Kana"},{"givenName":"Akari","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"614","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"261377/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/261377/profile-ja.html"},{"nameIdentifier":"80585026","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80585026"}]},{"creatorNames":[{"creatorName":"ヨコタ, ケンジ","creatorNameLang":"ja"},{"creatorName":"ヨコタ, ケンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Yokota, Kenji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-15"}],"displaytype":"detail","filename":"microorganisms_10_12_2495.pdf","filesize":[{"value":"716 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011654/files/microorganisms_10_12_2495.pdf"},"version_id":"e557fe1d-0316-434b-9acc-1d334019e1cc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Helicobacter pylori","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nitrate-reducing bacteria","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-8","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF-α","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cell cycle","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Helicobacter pylori and Nitrate-Reducing Bacteria Coculture on Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Helicobacter pylori and Nitrate-Reducing Bacteria Coculture on Cells","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-03-15"},"publish_date":"2024-03-15","publish_status":"0","recid":"2011654","relation_version_is_last":true,"title":["Effects of Helicobacter pylori and Nitrate-Reducing Bacteria Coculture on Cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:15:27.765351+00:00"}