{"created":"2025-01-14T00:45:04.477021+00:00","id":2011662,"links":{},"metadata":{"_buckets":{"deposit":"9dba59c8-3453-4212-8a6f-2186cf9c80fa"},"_deposit":{"created_by":7,"id":"2011662","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011662"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011662","sets":["1713853213384:1713853295607"]},"author_link":["680"],"control_number":"2011662","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-04-06","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"1924","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Nature Communications","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Wnt signaling is required to maintain bipotent progenitors for neural and paraxial mesoderm cells, the neuromesodermal progenitor (NMP) cells that reside in the epiblast and tailbud. Since epiblast/tailbud cells receive Wnt ligands produced by one another, this exchange may average out the heterogeneity of Wnt signaling levels among these cells. Here, we examined this possibility by replacing endogenous Wnt3a with a receptor-fused form that activates signaling in producing cells, but not in neighboring cells. Mutant mouse embryos show a unique phenotype in which maintenance of many NMP cells is impaired, although some cells persist for long periods. The epiblast cell population of these embryos increases heterogeneity in Wnt signaling levels as embryogenesis progresses and are sensitive to retinoic acid, an endogenous antagonist of NMP maintenance. Thus, mutual intercellular exchange of Wnt ligands in the epiblast cell population reduces heterogeneity and achieves robustness to environmental stress.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20411723","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12645905","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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ユウスケ","creatorNameLang":"ja"},{"creatorName":"ミイ, ユウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Mii, Yusuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカダ, リツコ","creatorNameLang":"ja"},{"creatorName":"タカダ, リツコ","creatorNameLang":"ja-Kana"},{"creatorName":"Takada, Ritsuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"シノヅカ, タクマ","creatorNameLang":"ja"},{"creatorName":"シノヅカ, タクマ","creatorNameLang":"ja-Kana"},{"creatorName":"Shinozuka, Takuma","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"竹本, 龍也","creatorNameLang":"ja"},{"creatorName":"タケモト, タツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Takemoto, Tatsuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"竹本","familyNameLang":"ja"},{"familyName":"タケモト","familyNameLang":"ja-Kana"},{"familyName":"Takemoto","familyNameLang":"en"}],"givenNames":[{"givenName":"龍也","givenNameLang":"ja"},{"givenName":"タツヤ","givenNameLang":"ja-Kana"},{"givenName":"Tatsuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"680","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"274209/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/274209/profile-ja.html"},{"nameIdentifier":"30443899","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30443899"}]},{"creatorNames":[{"creatorName":"ホンダ, ナオキ","creatorNameLang":"ja"},{"creatorName":"ホンダ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Honda, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカダ, シンジ","creatorNameLang":"ja"},{"creatorName":"タカダ, シンジ","creatorNameLang":"ja-Kana"},{"creatorName":"Takada, Shinji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-03-15"}],"displaytype":"detail","filename":"ncomms_14_1924.pdf","filesize":[{"value":"12.1 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011662/files/ncomms_14_1924.pdf"},"version_id":"a75afced-136a-4873-be41-bdb07420796d"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-03-15"},"publish_date":"2024-03-15","publish_status":"0","recid":"2011662","relation_version_is_last":true,"title":["Intercellular exchange of Wnt ligands reduces cell population heterogeneity during embryogenesis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T12:36:10.261169+00:00"}