{"created":"2025-01-14T00:47:09.496041+00:00","id":2011685,"links":{},"metadata":{"_buckets":{"deposit":"b77ebdfe-5399-42dd-8055-49cb9d8fb601"},"_deposit":{"created_by":7,"id":"2011685","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011685"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011685","sets":["1713853213384:1713853295607"]},"author_link":["527"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"383","bibliographicPageStart":"379","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Human Cell","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Down’s syndrome is one of the most common human congenital genetic diseases and affected patients have increased risk of periodontal disease. To examine involvement of the disease with periodontal disease development, we established immortalized periodontal ligament cells obtained from a Down’s syndrome patient by use of SV40T-Ag and hTERT gene transfection. Expressions of SV40T-Ag and hTERT were observed in periodontal ligament cell-derived immortalized cells established from healthy (STPDL) and Down’s syndrome patient (STPDLDS) samples. Primary cultured periodontal ligament cells obtained from a healthy subject (pPDL) had a limited number of population doublings (< 40), while STPDL and STPDLDS cells continued to grow with more than 80 population doublings. Primary cultured periodontal ligament cells obtained from the patient showed a chromosome pattern characteristic of Down’s syndrome with trisomy 21, whereas STPDLDS samples showed a large number of abnormal chromosomes in those results. Gene expression analysis revealed that expression of DSCR-1 in STPDLDS is greater than that in STPDL. These results suggest that the newly established STPDLDS cell line may be a useful tool for study of periodontal disease in Down’s syndrome patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japan Human Cell Society","subitem_publisher_language":"en"},{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"17490774","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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マスミ","creatorNameLang":"ja"},{"creatorName":"クギノ, マスミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kugino, Masumi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"長谷川, 智一","creatorNameLang":"ja"},{"creatorName":"ハセガワ, トモカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Hasegawa, Tomokazu","creatorNameLang":"en"}],"familyNames":[{"familyName":"長谷川","familyNameLang":"ja"},{"familyName":"ハセガワ","familyNameLang":"ja-Kana"},{"familyName":"Hasegawa","familyNameLang":"en"}],"givenNames":[{"givenName":"智一","givenNameLang":"ja"},{"givenName":"トモカズ","givenNameLang":"ja-Kana"},{"givenName":"Tomokazu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"527","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"229264/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/229264/profile-ja.html"},{"nameIdentifier":"50274668","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50274668"}]},{"creatorNames":[{"creatorName":"ヨシムラ, ケンタロウ","creatorNameLang":"ja"},{"creatorName":"ヨシムラ, ケンタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshimura, Kentaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ササ, キヨヒト","creatorNameLang":"ja"},{"creatorName":"ササ, キヨヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Sasa, Kiyohito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"キノシタ, ミツヒロ","creatorNameLang":"ja"},{"creatorName":"キノシタ, ミツヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Kinoshita, Mitsuhiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ニッタ, マサカズ","creatorNameLang":"ja"},{"creatorName":"ニッタ, マサカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Nitta, Masakazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナガタ, カリン","creatorNameLang":"ja"},{"creatorName":"ナガタ, カリン","creatorNameLang":"ja-Kana"},{"creatorName":"Nagata, Karin","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"スギヤマ, トモミ","creatorNameLang":"ja"},{"creatorName":"スギヤマ, トモミ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugiyama, Tomomi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カミジョウ, リュウタロウ","creatorNameLang":"ja"},{"creatorName":"カミジョウ, リュウタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kamijo, Ryutaro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"フナツ, タカヒロ","creatorNameLang":"ja"},{"creatorName":"フナツ, タカヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Funatsu, Takahiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-02-26"}],"displaytype":"detail","filename":"hc_35_1_379.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011685/files/hc_35_1_379.pdf"},"version_id":"f738a4fd-c611-4997-882c-dc5051e793c9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Periodontal ligament cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Down’s syndrome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DSCR-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SV40T-Ag","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hTERT","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Establishment of Down’s syndrome periodontal ligament cells by transfection with SV40T-Ag and hTERT","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Establishment of Down’s syndrome periodontal ligament cells by transfection with SV40T-Ag and hTERT","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-02-26"},"publish_date":"2024-02-26","publish_status":"0","recid":"2011685","relation_version_is_last":true,"title":["Establishment of Down’s syndrome periodontal ligament cells by transfection with SV40T-Ag and hTERT"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T09:20:05.937706+00:00"}