{"created":"2025-01-14T01:03:47.602654+00:00","id":2011875,"links":{},"metadata":{"_buckets":{"deposit":"b8359968-cea9-4642-a6b8-6d9fd9813169"},"_deposit":{"created_by":7,"id":"2011875","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011875"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011875","sets":["1713853213384:1713853296295:1716267878536:1716268699858"]},"author_link":["1316","1430","1574","1584"],"control_number":"2011875","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"成長ホルモンシグナルにおけるα-klothoの関与","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"229","bibliographicPageStart":"221","bibliographicVolumeNumber":"74","bibliographic_titles":[{"bibliographic_title":"Journal of Clinical Biochemistry and Nutrition","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Growth hormone (GH) exerts multiple effects on different organs directly or via its main mediator, insulin-like growth factor1 (IGF1). In this study, we focused on the novel relationship between GH action and the antiaging hormone α-klotho. Immunofluorescent staining of α-klotho was observed in the renal distal tubules and pituitary glands of somatostatin- and GH-positive cells in wild-type (WT) mice. Treatment of 4-week-old WT mice with GH increased IGF1 mRNA expression in the pituitary gland, liver, heart, kidney, and bone but increased α-klotho mRNA expression only in the pituitary gland, kidney, and bone. Increased α-klotho protein levels were observed in the kidney but not in the pituitary gland. No induction of α-klotho RNA expression by GH was observed in juvenile mice with kidney disease, indicating GH resistance. Furthermore, GH and α-klotho supplementation in HEK293 cells transfected with GHR increased Janus kinase 2 mRNA (a GH downstream signal) expression compared to supple­mentation with GH alone. In conclusion, we suggest that 1) the kidney is the main source of secreted α-klotho, which is detected in blood by the downstream action of GH, 2) α-klotho induction by GH is resistant in kidney disease, and 3) α-klotho might be an enhanced regulator of GH signaling.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for Free Radical Research Japan","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09120009","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"18805086","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10710201","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3775号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（栄養学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-02-22"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Megumi Koikeの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医科栄養学研究科（医科栄養学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲栄第303号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3164/jcbn.23-127"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3164/jcbn.23-127","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"405981"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小池, 萌","creatorNameLang":"ja"},{"creatorName":"コイケ, メグミ","creatorNameLang":"ja-Kana"},{"creatorName":"Koike, Megumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"小池","familyNameLang":"ja"},{"familyName":"コイケ","familyNameLang":"ja-Kana"},{"familyName":"Koike","familyNameLang":"en"}],"givenNames":[{"givenName":"萌","givenNameLang":"ja"},{"givenName":"メグミ","givenNameLang":"ja-Kana"},{"givenName":"Megumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1316","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"405934/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/405934/profile-ja.html"},{"nameIdentifier":"71000064","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=71000064"}]},{"creatorNames":[{"creatorName":"サトウ, テツヒコ","creatorNameLang":"ja"},{"creatorName":"サトウ, テツヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Tetsuhiko","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"塩﨑, 雄治","creatorNameLang":"ja"},{"creatorName":"シオザキ, ユウヂ","creatorNameLang":"ja-Kana"},{"creatorName":"Shiozaki, Yuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"塩﨑","familyNameLang":"ja"},{"familyName":"シオザキ","familyNameLang":"ja-Kana"},{"familyName":"Shiozaki","familyNameLang":"en"}],"givenNames":[{"givenName":"雄治","givenNameLang":"ja"},{"givenName":"ユウヂ","givenNameLang":"ja-Kana"},{"givenName":"Yuji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1430","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"375089/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/375089/profile-ja.html"}]},{"creatorNames":[{"creatorName":"コミヤ, アオイ","creatorNameLang":"ja"},{"creatorName":"コミヤ, アオイ","creatorNameLang":"ja-Kana"},{"creatorName":"Komiya, Aoi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミウラ, ミヅキ","creatorNameLang":"ja"},{"creatorName":"ミウラ, ミヅキ","creatorNameLang":"ja-Kana"},{"creatorName":"Miura, Mizuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒガシ, アヤミ","creatorNameLang":"ja"},{"creatorName":"ヒガシ, アヤミ","creatorNameLang":"ja-Kana"},{"creatorName":"Higashi, Ayami","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシカワ, アカネ","creatorNameLang":"ja"},{"creatorName":"イシカワ, アカネ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishikawa, Akane","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タカヤナギ, カオリ","creatorNameLang":"ja"},{"creatorName":"タカヤナギ, カオリ","creatorNameLang":"ja-Kana"},{"creatorName":"Takayanagi, Kaori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウガ, ミノリ","creatorNameLang":"ja"},{"creatorName":"ウガ, ミノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Uga, Minori","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"宮本, 賢一","creatorNameLang":"ja"},{"creatorName":"ミヤモト, ケンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Miyamoto, Ken-ichi","creatorNameLang":"en"}],"familyNames":[{"familyName":"宮本","familyNameLang":"ja"},{"familyName":"ミヤモト","familyNameLang":"ja-Kana"},{"familyName":"Miyamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"賢一","givenNameLang":"ja"},{"givenName":"ケンイチ","givenNameLang":"ja-Kana"},{"givenName":"Ken-ichi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1574","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60127/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60127/profile-ja.html"},{"nameIdentifier":"70174208","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70174208"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"瀬川, 博子","creatorNameLang":"ja"},{"creatorName":"セガワ, ヒロコ","creatorNameLang":"ja-Kana"},{"creatorName":"Segawa, Hiroko","creatorNameLang":"en"}],"familyNames":[{"familyName":"瀬川","familyNameLang":"ja"},{"familyName":"セガワ","familyNameLang":"ja-Kana"},{"familyName":"Segawa","familyNameLang":"en"}],"givenNames":[{"givenName":"博子","givenNameLang":"ja"},{"givenName":"ヒロコ","givenNameLang":"ja-Kana"},{"givenName":"Hiroko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1584","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60146/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60146/profile-ja.html"},{"nameIdentifier":"70325257","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70325257"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-13"}],"displaytype":"detail","filename":"k3775_abstract_review.pdf","filesize":[{"value":"192 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2011875/files/k3775_abstract_review.pdf"},"version_id":"d730ed4a-3412-42e3-8742-66dd6c199e47"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-06-06"}],"displaytype":"detail","filename":"k3775_fulltext.pdf","filesize":[{"value":"1.33 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2011875/files/k3775_fulltext.pdf"},"version_id":"1ec5bf99-2cf7-4c76-85f8-5ba3e20b12ac"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"growth hormone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"α-klotho","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"kidney","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CKD","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"GH-resistant","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Involvement of α-klotho in growth hormone (GH) signaling","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Involvement of α-klotho in growth hormone (GH) signaling","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268699858"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-02"},"publish_date":"2024-05-02","publish_status":"0","recid":"2011875","relation_version_is_last":true,"title":["Involvement of α-klotho in growth hormone (GH) signaling"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T07:34:13.092448+00:00"}