{"created":"2025-01-14T01:10:29.560822+00:00","id":2011948,"links":{},"metadata":{"_buckets":{"deposit":"c5b3c6a4-d0ad-422e-a429-85aa215b13b0"},"_deposit":{"created_by":7,"id":"2011948","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011948"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011948","sets":["1713853213384:1713853295607"]},"author_link":["288"],"control_number":"2011948","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"sPLA2- IID, an Immunosuppressive sPLA2","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-05-21","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"30","bibliographicPageEnd":"15601","bibliographicPageStart":"15588","bibliographicVolumeNumber":"291","bibliographic_titles":[{"bibliographic_title":"Journal of Biological Chemistry","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Phospholipase A2 enzymes have long been implicated in the promotion of inflammation by mobilizing pro-inflammatory lipid mediators, yet recent evidence suggests that they also contribute to anti-inflammatory or pro-resolving programs. Group IID-secreted phospholipase A2 (sPLA2-IID) is abundantly expressed in dendritic cells in lymphoid tissues and resolves the Th1 immune response by controlling the steady-state levels of anti-inflammatory lipids such as docosahexaenoic acid and its metabolites. Here, we show that psoriasis and contact dermatitis were exacerbated in Pla2g2d-null mice, whereas they were ameliorated in Pla2g2d-overexpressing transgenic mice, relative to littermate wild-type mice. These phenotypes were associated with concomitant alterations in the tissue levels of ω3 polyunsaturated fatty acid (PUFA) metabolites, which had the capacity to reduce the expression of pro-inflammatory and Th1/Th17- type cytokines in dendritic cells or lymph node cells. In the context of cancer, however, Pla2g2d deficiency resulted in marked attenuation of skin carcinogenesis, likely because of the augmented anti-tumor immunity. Altogether, these results underscore a general role of sPLA2-IID as an immunosuppressive sPLA2 that allows the microenvironmental lipid balance toward an anti-inflammatory state, exerting beneficial or detrimental impact depending upon distinct pathophysiological contexts in inflammation and cancer.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Society for Biochemistry and Molecular Biology","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY license.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"00219258","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"1083351X","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA1202441X","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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マリコ","creatorNameLang":"ja"},{"creatorName":"サトウ, マリコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sato, Mariko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケトミ, ヨシタカ","creatorNameLang":"ja"},{"creatorName":"タケトミ, ヨシタカ","creatorNameLang":"ja-Kana"},{"creatorName":"Taketomi, Yoshitaka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タヤ, チョウジ","creatorNameLang":"ja"},{"creatorName":"タヤ, チョウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Taya, Choji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ムラマツ, カズアキ","creatorNameLang":"ja"},{"creatorName":"ムラマツ, カズアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Muramatsu, Kazuaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Gelb, Michael 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Cancer","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-21"},"publish_date":"2024-05-21","publish_status":"0","recid":"2011948","relation_version_is_last":true,"title":["Dual Roles of Group IID Phospholipase A2 in Inflammation and Cancer"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-30T05:31:15.433989+00:00"}