{"created":"2025-01-14T01:11:52.988557+00:00","id":2011962,"links":{},"metadata":{"_buckets":{"deposit":"42e019bc-4624-4c17-80fc-2e1017768b12"},"_deposit":{"created_by":7,"id":"2011962","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2011962"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02011962","sets":["1713853213384:1713853295607"]},"author_link":["1543","935","788","552","876"],"control_number":"2011962","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-07-03","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"108456","bibliographicVolumeNumber":"108","bibliographic_titles":[{"bibliographic_title":"International Journal of Surgery Case Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction and importance: Denosumab is a new standard treatment for bone disease caused by multiple myeloma. There are a few reports of atypical femoral fracture in patients with multiple myeloma, all of which were associated with long-term use of bisphosphonate. Here, we report the first case of denosumab-induced atypical femoral fracture in a patient with multiple myeloma.\nCase presentation: A 71-year-old woman with multiple myeloma developed dull pain in her right thigh 8 months after restarting high-dose denosumab following its initial administration for 4 months and subsequent withdrawal for 2 years. Fourteen months later, complete atypical femoral fracture occurred. Osteosynthesis was achieved using an intramedullary nail and she was switched to oral bisphosphonate 7 months after cessation of denosumab. There was no exacerbation of the multiple myeloma. Bone union was achieved and she recovered to her pre-injury level of activities. The oncological outcome was alive with disease at 2 years after surgery.\nClinical discussion: Prodromal symptoms such as thigh pain and radiographical finding of thickening of the lateral cortex in the subtrochanteric region of the femur were attributed to denosumab-induced atypical femoral fracture in the case. A unique aspect of this case worth highlighting is that the fracture occurred after short-term denosumab use. This may be associated with multiple myeloma or other medication including dexamethasone and cyclophosphamide.\nConclusion: Atypical femoral fracture may occur in patients with multiple myeloma who receive denosumab, even for a short period. Attending physicians should be cognizant of the early symptoms and signs of this fracture.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"IJS Publishing Group","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"22102612","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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denosumab : A case report and literature review","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Atypical femoral fracture in a multiple myeloma patient undergoing treatment with denosumab : A case report and literature review","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-14"},"publish_date":"2024-06-14","publish_status":"0","recid":"2011962","relation_version_is_last":true,"title":["Atypical femoral fracture in a multiple myeloma patient undergoing treatment with denosumab : A case report and literature review"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:47:18.052171+00:00"}