{"created":"2025-01-14T01:16:36.940554+00:00","id":2012014,"links":{},"metadata":{"_buckets":{"deposit":"7533dbfc-b596-45f1-a98f-21c3a44cd28a"},"_deposit":{"created_by":7,"id":"2012014","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2012014"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012014","sets":["1713853213384:1713853296295:1716267877313:1716268556148"]},"author_link":["1678","622","1705","1423"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"TNF-αで刺激されたヒト口腔上皮細胞の炎症性メディエーターならびに抗酸化タンパク質発現に対するエルシンの影響","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-08-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"54","bibliographicPageStart":"49","bibliographicVolumeNumber":"46","bibliographic_titles":[{"bibliographic_title":"Immunopharmacology and Immunotoxicology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Periodontitis is a chronic inflammatory disease induced by periodontal disease-causing bacteria. It has been shown that excessive immune response against bacteria is involved in periodontal tissue destruction including alveolar bone resorption. Erucin is a biologically active substance found in cruciferous plants such as arugula, and is classified as an isothiocyanate. No previous studies have attempted to use erucin in the treatment of periodontitis, and there are no papers that have examined the effects of erucin on periodontal resident cells. The purpose of this study was to analyze the effects of erucin on the production of inflammatory and antioxidant mediators produced by tumor necrosis factor (TNF)-α-stimulated TR146 cells, an oral epithelial cell line, including its effects on signaling molecules. Our results indicate that erucin suppresses interleukin (IL)-6 and CXC-chemokine ligand (CXCL)10 production and vascular cell adhesion molecule (VCAM)-1 expression in TNF-α-stimulated TR146 cells. In addition, erucin induced the production of the antioxidant enzymes, Heme Oxygenase (HO)-1 and NAD(P)H quinone dehydrogenase (NQO)1 in TR146 cells. Furthermore, erucin suppressed TNF-α-stimulated nuclear factor (NF)-κB, signal transducer and activator of transcription (STAT)3, and p70S6K-S6 signaling pathways in TR146 cells. We have shown that erucin has anti-inflammatory effects on oral epithelial cells and also induces the production of antioxidant mediators. These results suggest that erucin may provide a new anti-inflammatory agent that can be used in the treatment of periodontitis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"08923973","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"15322513","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA10695924","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3788号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（歯学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-14"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Masahiro Shimoyamaの学位論文として提出され，学位審査・授与の対象となっている。\nThis is an Accepted Manuscript of an article published by Taylor & Francis in Immunopharmacology and Immunotoxicology on 30/08/2023, available online at: https://doi.org/10.1080/08923973.2023.2250551\n学位授与者所属 : 徳島大学大学院口腔科学研究科（口腔科学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲口第502号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1080/08923973.2023.2250551"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/08923973.2023.2250551","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"404826"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"下山, 真弘","creatorNameLang":"ja"},{"creatorName":"シモヤマ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Shimoyama, 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and antioxidant enzymes' expression in TNF-α-stimulated human oral epithelial cells"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-03T06:41:55.947288+00:00"}