{"created":"2025-01-14T01:18:40.427973+00:00","id":2012034,"links":{},"metadata":{"_buckets":{"deposit":"79165b46-af1b-4fe9-a810-984e34f7cf8d"},"_deposit":{"created_by":7,"id":"2012034","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2012034"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012034","sets":["1713853213384:1713853295607"]},"author_link":["717"],"control_number":"2012034","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"VDR for Epigenetic Regulations in Bone Biology","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"12","bibliographicPageStart":"3","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Journal of Bone Metabolism","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Vitamin D (VD) is essential for bone health, and VD or its analogues are widely used in clinics to ameliorate bone loss. The targets and mode of VD anti-osteoporotic actions appear to be different from those of other classes of drugs modulating bone remodeling. VD exerts its biological activities through the nuclear VD receptor (VDR)-mediated transcriptional regulation of target mRNA and non-coding RNA genes. VD-induced gene regulation involves epigenetic modifications of chromatin conformation at the target loci as well as reconfiguration of higher-order chromosomal organization through VDR-mediated recruitment of various regulatory factors. Enhancer RNAs (eRNA), a class of non-coding enhancer-derived RNAs, have recently emerged as VDR target gene candidates that act through reorganization of chromatin looping to induce enhancer-promoter interaction in activation of mRNA-encoding genes. This review outlines the molecular mechanisms of VD actions mediated by the VDR and suggests novel function of eRNAs in VDR transactivation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Korean Society for Bone and Mineral Research","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"22876375","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"22877029","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.11005/jbm.2019.26.1.3"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.11005/jbm.2019.26.1.3","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"401571"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"沢津橋, 俊","creatorNameLang":"ja"},{"creatorName":"サワツバシ, シュン","creatorNameLang":"ja-Kana"},{"creatorName":"Sawatsubashi, Shun","creatorNameLang":"en"}],"familyNames":[{"familyName":"沢津橋","familyNameLang":"ja"},{"familyName":"サワツバシ","familyNameLang":"ja-Kana"},{"familyName":"Sawatsubashi","familyNameLang":"en"}],"givenNames":[{"givenName":"俊","givenNameLang":"ja"},{"givenName":"シュン","givenNameLang":"ja-Kana"},{"givenName":"Shun","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"278225/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/278225/profile-ja.html"},{"nameIdentifier":"70535103","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70535103"}]},{"creatorNames":[{"creatorName":"ニシムラ, コウイチ","creatorNameLang":"ja"},{"creatorName":"ニシムラ, コウイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishimura, Koichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モリ, ジンイチ","creatorNameLang":"ja"},{"creatorName":"モリ, ジンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Mori, Jinichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kouzmenko, Alexander","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カトウ, シゲアキ","creatorNameLang":"ja"},{"creatorName":"カトウ, シゲアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kato, Shigeaki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-06-24"}],"displaytype":"detail","filename":"jbm_26_1_3.pdf","filesize":[{"value":"1.35 MB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012034/files/jbm_26_1_3.pdf"},"version_id":"aa6793e9-e8cf-4944-a27c-d1b620c1cc59"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Chromatin reorganization","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Enhancer RNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Non-coding RNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Vitamin D","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Vitamin D receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The Function of the Vitamin D Receptor and a Possible Role of Enhancer RNA in Epigenomic Regulation of Target Genes : Implications for Bone Metabolism","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The Function of the Vitamin D Receptor and a Possible Role of Enhancer RNA in Epigenomic Regulation of Target Genes : Implications for Bone Metabolism","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-06-24"},"publish_date":"2024-06-24","publish_status":"0","recid":"2012034","relation_version_is_last":true,"title":["The Function of the Vitamin D Receptor and a Possible Role of Enhancer RNA in Epigenomic Regulation of Target Genes : Implications for Bone Metabolism"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-03T02:48:27.105534+00:00"}