{"created":"2025-01-14T01:18:53.450695+00:00","id":2012036,"links":{},"metadata":{"_buckets":{"deposit":"2ff4eafd-a83c-47aa-8b4d-80f754e6ebb0"},"_deposit":{"created_by":7,"id":"2012036","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2012036"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012036","sets":["1713853213384:1713853295607"]},"author_link":["851"],"item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"Dental Pulp Stem Cell Factors for Treating LF","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-06-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1424","bibliographicPageStart":"1416","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"STEM CELLS Translational Medicine","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Chronic liver injury from various causes often results in liver fibrosis (LF). Although the liver possesses endogenous tissue-repairing activities, these can be overcome by sustained inflammation and excessive fibrotic scar formation. Advanced LF leads to irreversible cirrhosis and subsequent liver failure and/or hepatic cancer. Here, using the mouse carbon tetrachloride (CCl4)-induced LF model, we showed that a single intravenous administration of stem cells derived from human exfoliated deciduous teeth (SHEDs) or of SHED-derived serum-free conditioned medium (SHED-CM) resulted in fibrotic scar resolution. SHED-CM suppressed the gene expression of proinflammatory mediators, such as TNF-α, IL-1β, and iNOS, and eliminated activated hepatic stellate cells by inducing their apoptosis, but protected parenchymal hepatocytes from undergoing apoptosis. In addition, SHED-CM induced tissue-repairing macrophages that expressed high levels of the profibrinolytic factor, matrix metalloproteinase 13. Furthermore, SHED-CM suppressed the CCl4-induced apoptosis of primary cultured hepatocytes. SHED-CM contained a high level of hepatocyte growth factor (HGF). Notably, HGF-depleted SHED-CM (dHGF-CM) did not suppress the proinflammatory response or resolve fibrotic scarring. Furthermore, SHED-CM, but not dHGF-CM, inhibited CCl4-induced hepatocyte apoptosis. These results suggest that HGF plays a central role in the SHED-CM-mediated resolution of LF. Taken together, our findings suggest that SHED-CM provides multifaceted therapeutic benefits for the treatment of LF.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"AlphaMed Press","subitem_publisher_language":"en"},{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"STEM CELLS Translational Medicine® is a monthly, peer-reviewed, online only, open access journal.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"21576580","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"21576564","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA12597700","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.5966/sctm.2015-0353"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.5966/sctm.2015-0353","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"321509"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ヒラタ, マリナ","creatorNameLang":"ja"},{"creatorName":"ヒラタ, マリナ","creatorNameLang":"ja-Kana"},{"creatorName":"Hirata, Marina","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イシガミ, マサトシ","creatorNameLang":"ja"},{"creatorName":"イシガミ, マサトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Ishigami, Masatoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マツシタ, ヨシヒロ","creatorNameLang":"ja"},{"creatorName":"マツシタ, ヨシヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsushita, Yoshihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イトウ, タカノリ","creatorNameLang":"ja"},{"creatorName":"イトウ, タカノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Ito, Takanori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハットリ, ヒサシ","creatorNameLang":"ja"},{"creatorName":"ハットリ, ヒサシ","creatorNameLang":"ja-Kana"},{"creatorName":"Hattori, Hisashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヒビ, ヒデハル","creatorNameLang":"ja"},{"creatorName":"ヒビ, ヒデハル","creatorNameLang":"ja-Kana"},{"creatorName":"Hibi, Hideharu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ゴトウ, ヒデミ","creatorNameLang":"ja"},{"creatorName":"ゴトウ, ヒデミ","creatorNameLang":"ja-Kana"},{"creatorName":"Goto, Hidemi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ウエダ, ミノル","creatorNameLang":"ja"},{"creatorName":"ウエダ, ミノル","creatorNameLang":"ja-Kana"},{"creatorName":"Ueda, Minoru","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山本, 朗仁","creatorNameLang":"ja"},{"creatorName":"ヤマモト, アキヒト","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Akihito","creatorNameLang":"en"}],"familyNames":[{"familyName":"山本","familyNameLang":"ja"},{"familyName":"ヤマモト","familyNameLang":"ja-Kana"},{"familyName":"Yamamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"朗仁","givenNameLang":"ja"},{"givenName":"アキヒト","givenNameLang":"ja-Kana"},{"givenName":"Akihito","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"851","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"321104/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/321104/profile-ja.html"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-21"}],"displaytype":"detail","filename":"sctm_5_10_1416.pdf","filesize":[{"value":"2.04 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012036/files/sctm_5_10_1416.pdf"},"version_id":"b7c25364-a6fd-443b-b0ab-6d503f54226c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Liver fibrosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dental pulp stem cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Conditioned media","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Macrophages","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-21"},"publish_date":"2024-05-21","publish_status":"0","recid":"2012036","relation_version_is_last":true,"title":["Multifaceted Therapeutic Benefits of Factors Derived From Dental Pulp Stem Cells for Mouse Liver Fibrosis"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T12:21:49.590460+00:00"}