{"created":"2025-01-14T01:19:00.451527+00:00","id":2012037,"links":{},"metadata":{"_buckets":{"deposit":"9f54a7b9-24b6-4525-99cb-c2b5a5e29e09"},"_deposit":{"created_by":7,"id":"2012037","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2012037"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012037","sets":["1713853213384:1713853296295:1716268427747:1716268703682"]},"author_link":["1540","834","341","1214"],"control_number":"2012037","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"肺腺癌においてdipeptidyl peptidase‑like 6 (DPP-6)遺伝子のDNAメチル化は予後の指標となる","subitem_alternative_title_language":"ja"},{"subitem_alternative_title":"ABERRANT METHYLATION OF DPP6 IN LUNG ADENOCARCINOMA","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-04-05","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"206","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"Oncology Letters","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We previously performed the genome‑wide screening of aberrantly methylated CpG islands (CGIs) using the paired tumorous and non‑tumorous tissues of 12 lung adenocarcinomas (LADC). In comparisons with paired normal lung tissues, dipeptidyl peptidase‑like 6 (DPP6) has been identified as the most significantly hypermethylated CGI in LADC. DPP6 is a protein that modulates A‑type potassium channels in the somatodendritic compartments of neurons, which play a role in synaptic plasticity. Previous studies have showed that DPP6 is downregulated in cancers, such as acute myeloid leukemia and melanoma, but upregulated in colon cancer, which is attributed to hyper‑ and hypomethylation, respectively. The present study investigated the methylation and expression levels of DPP6 and its prognostic value in patients with LADC. The DNA methylation and mRNA expression levels of DPP6 in surgically resected LADC tissues were examined by bisulfite pyrosequencing and reverse transcription‑quantitative PCR, respectively. The DNA methylation and mRNA expression levels of DPP6 were both significantly higher in LADC tissues compared with in normal lung tissues (n=25; P<0.0001). Overall and disease‑free survival rates were significantly higher in LADC with high mRNA expression levels compared with those with low levels. In conclusion, epigenetic alterations in DPP6 were significantly higher in LADC tissues compared with in normal lung tissues, which may contribute to the malignant features and worse prognosis of these patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Spandidos Publications","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"17921074","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"17921082","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3805号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（保健学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-22"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者Batkhishig Munkhjargalの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院保健科学研究科（保健学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲保第68号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.3892/ol.2023.13792"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.3892/ol.2023.13792","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"404636"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ムンフジャラガル, 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ナオヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawakita, Naoya","creatorNameLang":"en"}],"familyNames":[{"familyName":"河北","familyNameLang":"ja"},{"familyName":"カワキタ","familyNameLang":"ja-Kana"},{"familyName":"Kawakita","familyNameLang":"en"}],"givenNames":[{"givenName":"直也","givenNameLang":"ja"},{"givenName":"ナオヤ","givenNameLang":"ja-Kana"},{"givenName":"Naoya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"834","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"310688/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/310688/profile-ja.html"}]},{"creatorNames":[{"creatorName":"鳥羽, 博明","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"341","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"滝沢, 宏光","creatorNameLang":"ja"}],"nameIdentifiers":[{"nameIdentifier":"1214","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-27"}],"displaytype":"detail","filename":"k3805_abstract.pdf","filesize":[{"value":"159 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2012037/files/k3805_abstract.pdf"},"version_id":"3bd26b26-758b-4f9d-b91b-69356d44f025"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-27"}],"displaytype":"detail","filename":"k3805_review.pdf","filesize":[{"value":"139 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adenocarcinoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Aberrant methylation of dipeptidyl peptidase‑like 6 as a potential prognostic biomarker for lung adenocarcinoma","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1716268703682"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-27"},"publish_date":"2024-05-27","publish_status":"0","recid":"2012037","relation_version_is_last":true,"title":["Aberrant methylation of dipeptidyl peptidase‑like 6 as a potential prognostic biomarker for lung adenocarcinoma"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-30T01:11:29.866892+00:00"}