{"created":"2025-01-14T01:26:21.999352+00:00","id":2012105,"links":{},"metadata":{"_buckets":{"deposit":"ea10c050-6398-4f29-8e10-9413f47899ba"},"_deposit":{"created_by":7,"id":"2012105","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2012105"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012105","sets":["1713853213384:1713853295607"]},"author_link":["199","1542"],"control_number":"2012105","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-12-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"257","bibliographicPageStart":"248","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Thoracic Cancer","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: An increased relative eosinophil count (REC) has potential as a predictive biomarker for a beneficial clinical response and outcome to cancer immunotherapies. Therefore, the present study investigated the impact of an increased posttreatment REC on the prognosis of non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs).\nMethods: We retrospectively reviewed all 151 patients diagnosed with NSCLC and treated with ICI monotherapy and blood test data between March 2016 and August 2021 at National Hospital Organization Kochi Hospital and Tokushima University.\nResults: A total of 151 patients with a mean age of 69 years were included. REC after 4 weeks of initial ICI monotherapy was higher than pretreatment REC in 87 patients but not in 64. REC after 4 weeks of the ICI treatment with and without an increased REC were 4.4 and 1.8%, respectively (p < 0.001). Disease control rates (DCR) were significantly higher in patients with than in those without an increased REC (84% vs. 47%, p < 0.001). The median overall survival (OS) of lung cancer patients with or without an increased REC were 674 and 234 days, respectively. A Kaplan–Meier univariate analysis revealed a significant difference in OS between the two groups (p < 0.001). A Cox proportional regression analysis identified an increased REC as an independent predictor of OS (p = 0.003).\nConclusion: ICI-treated NSCLC patients with an increased REC after 4 weeks of treatment had a better DCR and prognosis than the other patients examined.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"John Wiley & Sons Australia","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"17597706","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"17597714","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1111/1759-7714.15191"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1111/1759-7714.15191","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"405860"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"タケウチ, エイジ","creatorNameLang":"ja"},{"creatorName":"タケウチ, エイジ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeuchi, Eiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"荻野, 広和","creatorNameLang":"ja"},{"creatorName":"オギノ, ヒロカズ","creatorNameLang":"ja-Kana"},{"creatorName":"Ogino, Hirokazu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"コンドウ, ケンスケ","creatorNameLang":"ja"},{"creatorName":"コンドウ, ケンスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Kondo, Kensuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"オカノ, ヨシオ","creatorNameLang":"ja"},{"creatorName":"オカノ, ヨシオ","creatorNameLang":"ja-Kana"},{"creatorName":"Okano, Yoshio","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イチハラ, セイヤ","creatorNameLang":"ja"},{"creatorName":"イチハラ, セイヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Ichihara, Seiya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"國重, 道大","creatorNameLang":"ja"},{"creatorName":"クニシゲ, ミチヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Kunishige, Michihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カドタ, ナオキ","creatorNameLang":"ja"},{"creatorName":"カドタ, ナオキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kadota, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マチダ, ヒサノリ","creatorNameLang":"ja"},{"creatorName":"マチダ, ヒサノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Machida, Hisanori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ハタケヤマ, ノブオ","creatorNameLang":"ja"},{"creatorName":"ハタケヤマ, ノブオ","creatorNameLang":"ja-Kana"},{"creatorName":"Hatakeyama, Nobuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナルセ, ケイシ","creatorNameLang":"ja"},{"creatorName":"ナルセ, ケイシ","creatorNameLang":"ja-Kana"},{"creatorName":"Naruse, Keishi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"軒原, 浩","creatorNameLang":"ja"},{"creatorName":"ノキハラ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Nokihara, Hiroshi","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"篠原, 勉","creatorNameLang":"ja"},{"creatorName":"シノハラ, ツトム","creatorNameLang":"ja-Kana"},{"creatorName":"Shinohara, Tsutomu","creatorNameLang":"en"}],"familyNames":[{"familyName":"篠原","familyNameLang":"ja"},{"familyName":"シノハラ","familyNameLang":"ja-Kana"},{"familyName":"Shinohara","familyNameLang":"en"}],"givenNames":[{"givenName":"勉","givenNameLang":"ja"},{"givenName":"ツトム","givenNameLang":"ja-Kana"},{"givenName":"Tsutomu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"199","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"124424/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/124424/profile-ja.html"},{"nameIdentifier":"70284289","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70284289"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"西岡, 安彦","creatorNameLang":"ja"},{"creatorName":"ニシオカ, ヤスヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishioka, Yasuhiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"西岡","familyNameLang":"ja"},{"familyName":"ニシオカ","familyNameLang":"ja-Kana"},{"familyName":"Nishioka","familyNameLang":"en"}],"givenNames":[{"givenName":"安彦","givenNameLang":"ja"},{"givenName":"ヤスヒコ","givenNameLang":"ja-Kana"},{"givenName":"Yasuhiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1542","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60062/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60062/profile-ja.html"},{"nameIdentifier":"70274199","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70274199"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-07-18"}],"displaytype":"detail","filename":"tc_15_3_248.pdf","filesize":[{"value":"959 KB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012105/files/tc_15_3_248.pdf"},"version_id":"abe4ba3d-ee7e-4c21-ab13-aad7876265b6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dynamic biomarker","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"immune checkpoint inhibitors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"increased eosinophil count","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"non-small cell lung cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"predictive factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"An increased relative eosinophil count as a predictive dynamic biomarker in non-small cell lung cancer patients treated with immune checkpoint inhibitors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"An increased relative eosinophil count as a predictive dynamic biomarker in non-small cell lung cancer patients treated with immune checkpoint inhibitors","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-07-18"},"publish_date":"2024-07-18","publish_status":"0","recid":"2012105","relation_version_is_last":true,"title":["An increased relative eosinophil count as a predictive dynamic biomarker in non-small cell lung cancer patients treated with immune checkpoint inhibitors"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-03T07:21:32.492081+00:00"}