{"created":"2025-01-14T01:28:16.364366+00:00","id":2012125,"links":{},"metadata":{"_buckets":{"deposit":"65a4d34f-1c30-4509-bdfc-40c6a6ce4c66"},"_deposit":{"created_by":7,"id":"2012125","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2012125"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012125","sets":["1713853213384:1713853295607"]},"author_link":["717"],"control_number":"2012125","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-09-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"11","bibliographicPageStart":"bvab150","bibliographicVolumeNumber":"5","bibliographic_titles":[{"bibliographic_title":"Journal of the Endocrine Society","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The androgen receptor (AR) plays an essential role in the development of prostate cancer, and androgen-deprivation therapy is used as a first-line treatment for prostate cancer. However, under androgen-deprivation therapy, castration-resistant prostate cancer inevitably arises, suggesting that the interacting transcriptional coregulators of AR are promising targets for developing novel therapeutics. In this study, we used novel proteomic techniques to evaluate the AR interactome, including biochemically labile binding proteins, which might go undetected by conventional purification methods. Using rapid immunoprecipitation mass spectrometry of endogenous proteins, we identified enhanced at puberty 1 (EAP1) as a novel AR coregulator, whereas its interaction with AR could not be detected under standard biochemical conditions. EAP1 enhanced the transcriptional activity of AR via the E3 ubiquitin ligase activity, and its ubiquitination substrate proteins included AR and HDAC1. Furthermore, in prostate cancer specimens, EAP1 expression was significantly correlated with AR expression as well as a poor prognosis of prostate cancer. Together, these results suggest that EAP1 is a novel AR coregulator that promotes AR activity and potentially plays a role in prostate cancer progression.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Endocrine Society","subitem_publisher_language":"en"},{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"24721972","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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ユウリ","creatorNameLang":"ja"},{"creatorName":"オツボ, ユウリ","creatorNameLang":"ja-Kana"},{"creatorName":"Otsubo, Yuri","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ノロ, エリカ","creatorNameLang":"ja"},{"creatorName":"ノロ, エリカ","creatorNameLang":"ja-Kana"},{"creatorName":"Noro, Erika","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"沢津橋, 俊","creatorNameLang":"ja"},{"creatorName":"サワツバシ, シュン","creatorNameLang":"ja-Kana"},{"creatorName":"Sawatsubashi, Shun","creatorNameLang":"en"}],"familyNames":[{"familyName":"沢津橋","familyNameLang":"ja"},{"familyName":"サワツバシ","familyNameLang":"ja-Kana"},{"familyName":"Sawatsubashi","familyNameLang":"en"}],"givenNames":[{"givenName":"俊","givenNameLang":"ja"},{"givenName":"シュン","givenNameLang":"ja-Kana"},{"givenName":"Shun","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"717","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"278225/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/278225/profile-ja.html"},{"nameIdentifier":"70535103","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70535103"}]},{"creatorNames":[{"creatorName":"シマ, ヒロキ","creatorNameLang":"ja"},{"creatorName":"シマ, ヒロキ","creatorNameLang":"ja-Kana"},{"creatorName":"Shima, Hiroki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サトウ, イクロウ","creatorNameLang":"ja"},{"creatorName":"サトウ, イクロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Satoh, Ikuro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"カワムラ, サダフミ","creatorNameLang":"ja"},{"creatorName":"カワムラ, サダフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawamura, Sadafumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"スズキ, タカシ","creatorNameLang":"ja"},{"creatorName":"スズキ, タカシ","creatorNameLang":"ja-Kana"},{"creatorName":"Suzuki, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"イガラシ, カズヒコ","creatorNameLang":"ja"},{"creatorName":"イガラシ, カズヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Igarashi, Kazuhiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"スガワラ, アキラ","creatorNameLang":"ja"},{"creatorName":"スガワラ, アキラ","creatorNameLang":"ja-Kana"},{"creatorName":"Sugawara, Akira","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-07-12"}],"displaytype":"detail","filename":"jes_5_11_bvab150.pdf","filesize":[{"value":"873 KB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012125/files/jes_5_11_bvab150.pdf"},"version_id":"3a3c0427-f0da-430a-b46f-8bd1afdee55b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"AR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"androgen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nuclear receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"coactivator","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"EAP1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"IRF2BPL","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-07-12"},"publish_date":"2024-07-12","publish_status":"0","recid":"2012125","relation_version_is_last":true,"title":["Identification and Functional Characterization of a Novel Androgen Receptor Coregulator, EAP1"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-04-28T06:06:01.599678+00:00"}