{"created":"2025-01-14T01:29:29.439274+00:00","id":2012138,"links":{},"metadata":{"_buckets":{"deposit":"7fdd147d-a470-4c37-bc87-765db9c1684b"},"_deposit":{"created_by":7,"id":"2012138","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2012138"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012138","sets":["1713853213384:1713853295607"]},"author_link":["1447"],"control_number":"2012138","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-01-02","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"227","bibliographicVolumeNumber":"14","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Heated tobacco products (HTPs) have emerged as novel alternatives to conventional cigarettes (CCs), marketed by the tobacco industry as having a reduced potential for harm. Nevertheless, a significant dearth of information remains regarding the long-term effects of HTPs on the central nervous system (CNS). Here, we sought to shed light on the repercussions of prolonged exposure to HTPs on the CNS, employing a mouse model mimicking prodromal Alzheimer’s disease (AD). Our study entailed subjecting App knock-in mice to 16 weeks of HTP exposure, administered 5 days per week, with serum cotinine concentration serving as confirmation of HTP exposure within this model. Histological analysis, aimed at assessing amyloid pathology, unveiled a minimal impact attributable to HTPs. However, exploration of differentially expressed genes in the cerebral cortex, using unadjusted p values, indicated an association between HTP exposure and non-inflammatory pathways, specifically linked to neurohypophyseal and neuropeptide hormone activity within the CNS. Of note, similar results have already been observed after exposure to CCs in vivo. Our study not only contributes insights into the potential non-inflammatory effects of HTPs within the context of AD pathogenesis but also underscores the significance of continued research to comprehend the full scope of their impact on the CNS.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/s41598-023-50941-4"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/s41598-023-50941-4","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"407266"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ヤマダ, ヒデタダ","creatorNameLang":"ja"},{"creatorName":"ヤマダ, ヒデタダ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamada, Hidetada","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤマザキ, ユウ","creatorNameLang":"ja"},{"creatorName":"ヤマザキ, ユウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamazaki, Yu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケバヤシ, ヨシコ","creatorNameLang":"ja"},{"creatorName":"タケバヤシ, ヨシコ","creatorNameLang":"ja-Kana"},{"creatorName":"Takebayashi, Yoshiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ヤザワ, キョウスケ","creatorNameLang":"ja"},{"creatorName":"ヤザワ, キョウスケ","creatorNameLang":"ja-Kana"},{"creatorName":"Yazawa, Kyosuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ササニシ, ミワコ","creatorNameLang":"ja"},{"creatorName":"ササニシ, ミワコ","creatorNameLang":"ja-Kana"},{"creatorName":"Sasanishi, Miwako","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"モトダ, アツコ","creatorNameLang":"ja"},{"creatorName":"モトダ, アツコ","creatorNameLang":"ja-Kana"},{"creatorName":"Motoda, Atsuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナカモリ, マサヒロ","creatorNameLang":"ja"},{"creatorName":"ナカモリ, マサヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamori, Masahiro","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"森野, 豊之","creatorNameLang":"ja"},{"creatorName":"モリノ, ヒロユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Morino, Hiroyuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"森野","familyNameLang":"ja"},{"familyName":"モリノ","familyNameLang":"ja-Kana"},{"familyName":"Morino","familyNameLang":"en"}],"givenNames":[{"givenName":"豊之","givenNameLang":"ja"},{"givenName":"ヒロユキ","givenNameLang":"ja-Kana"},{"givenName":"Hiroyuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1447","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"376094/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/376094/profile-ja.html"},{"nameIdentifier":"10397953","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10397953"}]},{"creatorNames":[{"creatorName":"タカハシ, テツヤ","creatorNameLang":"ja"},{"creatorName":"タカハシ, テツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Tetsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"マルヤマ, ヒロフミ","creatorNameLang":"ja"},{"creatorName":"マルヤマ, ヒロフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Maruyama, Hirofumi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-07-12"}],"displaytype":"detail","filename":"srep_14_227.pdf","filesize":[{"value":"1.26 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disease","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-07-12"},"publish_date":"2024-07-12","publish_status":"0","recid":"2012138","relation_version_is_last":true,"title":["The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's disease"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-02-03T02:44:59.495834+00:00"}