{"created":"2025-01-14T01:36:55.718845+00:00","id":2012224,"links":{},"metadata":{"_buckets":{"deposit":"47315575-3fcb-4212-bcb7-98909078e594"},"_deposit":{"created_by":7,"id":"2012224","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2012224"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012224","sets":["1713853213384:1713853295607"]},"author_link":["288"],"control_number":"2012224","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-10-04","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"87","bibliographicPageStart":"75","bibliographicVolumeNumber":"215","bibliographic_titles":[{"bibliographic_title":"Biochimie","bibliographic_titleLang":"fr"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Epidermal lipids play important roles in skin homeostasis and diseases. Psoriasis is an inflammatory disease characterized by keratinocyte hyperproliferation and Th17 immune responses. We previously reported that ethanolamine-type lysoplasmalogen (P-LPE), preferentially produced by group IIF secreted PLA2 (sPLA2-IIF/PLA2G2F) that is expressed in the suprabasal epidermis, promotes epidermal hyperplasia in psoriatic inflammation. Herein, we show that forcible degradation of epidermal P-LPE by topical application of recombinant lysophospholipase D (LyPls-PLD) from Thermocrispum, a lysoplasmalogen-specific hydrolase, attenuated epidermal hyperplasia and inflammation in imiquimod-induced and K5.Stat3C-transgenic mouse psoriasis models. In humans, P-LPE levels were elevated in the tape-stripped stratum corneum of patients with psoriasis. Moreover, in primary cultured human epidermal keratinocytes, aberrant cell proliferation and activation by psoriatic cytokines were sPLA2-IIF/P-LPE-dependent and were suppressed by the addition of LyPls-PLD with a decrease in P-LPE. These findings confirm that the sPLA2-IIF/P-LPE axis in the epidermis indeed regulates psoriasis, that P-LPE is a lipid biomarker that predicts the severity of psoriasis, and that pharmacological removal of this bioactive lipid is useful to prevent the disease. Thus, our study may lead to the development of drug discovery and diagnostic techniques based on this pathway.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"Société Française de Biochimie et Biologie Moléculaire (SFBBM)","subitem_publisher_language":"fr"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2023. This manuscript version is made available under the CC-BY-NC-ND 4.0 license\nhttps://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"16386183","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"03009084","subitem_source_identifier_type":"ISSN"},{"subitem_source_identifier":"AA11522535","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA00564792","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.biochi.2023.09.027"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.biochi.2023.09.027","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"410912"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"ハコイ, ハルカ","creatorNameLang":"ja"},{"creatorName":"ハコイ, ハルカ","creatorNameLang":"ja-Kana"},{"creatorName":"Hakoi, Haruka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ミキ, ヨシミ","creatorNameLang":"ja"},{"creatorName":"ミキ, ヨシミ","creatorNameLang":"ja-Kana"},{"creatorName":"Miki, Yoshimi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ノムラ, サキ","creatorNameLang":"ja"},{"creatorName":"ノムラ, サキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nomura, Saki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ナカジマ, キミコ","creatorNameLang":"ja"},{"creatorName":"ナカジマ, キミコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakajima, Kimiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"テラシマ ムラセ, チアキ","creatorNameLang":"ja"},{"creatorName":"テラシマ ムラセ, チアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Terashima-Murase, Chiaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タケイチ, タクヤ","creatorNameLang":"ja"},{"creatorName":"タケイチ, タクヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Takeichi, Takuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サノ, シゲトシ","creatorNameLang":"ja"},{"creatorName":"サノ, シゲトシ","creatorNameLang":"ja-Kana"},{"creatorName":"Sano, Shigetoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"アキヤマ, マサシ","creatorNameLang":"ja"},{"creatorName":"アキヤマ, マサシ","creatorNameLang":"ja-Kana"},{"creatorName":"Akiyama, Masashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"サカセガワ, シンイチ","creatorNameLang":"ja"},{"creatorName":"サカセガワ, シンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Sakasegawa, Shin-ichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"ムラカミ, マコト","creatorNameLang":"ja"},{"creatorName":"ムラカミ, マコト","creatorNameLang":"ja-Kana"},{"creatorName":"Murakami, Makoto","creatorNameLang":"en"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山本, 圭","creatorNameLang":"ja"},{"creatorName":"ヤマモト, ケイ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamamoto, Kei","creatorNameLang":"en"}],"familyNames":[{"familyName":"山本","familyNameLang":"ja"},{"familyName":"ヤマモト","familyNameLang":"ja-Kana"},{"familyName":"Yamamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"圭","givenNameLang":"ja"},{"givenName":"ケイ","givenNameLang":"ja-Kana"},{"givenName":"Kei","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"288","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"170514/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/170514/profile-ja.html"},{"nameIdentifier":"30304504","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30304504"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-10-04"}],"displaytype":"detail","filename":"biochi_215_75.pdf","filesize":[{"value":"4.24 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012224/files/biochi_215_75.pdf"},"version_id":"7ed96e99-b382-4af2-b30e-dad795138911"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Group IIF phospholipase A2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lysoplasmalogen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Thermocrispum lysophospholipase D","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Psoriasis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipidomics","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Lysophospholipase D from Thermocrispum limits psoriatic inflammation by hydrolyzing epidermal lysoplasmalogen produced by group IIF secreted phospholipase A2","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Lysophospholipase D from Thermocrispum limits psoriatic inflammation by hydrolyzing epidermal lysoplasmalogen produced by group IIF secreted phospholipase A2","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-08-28"},"publish_date":"2024-08-28","publish_status":"0","recid":"2012224","relation_version_is_last":true,"title":["Lysophospholipase D from Thermocrispum limits psoriatic inflammation by hydrolyzing epidermal lysoplasmalogen produced by group IIF secreted phospholipase A2"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T06:43:42.407375+00:00"}