{"created":"2025-01-14T01:41:41.756808+00:00","id":2012279,"links":{},"metadata":{"_buckets":{"deposit":"ce52975b-d857-4370-9f0c-8d3eb0b1c370"},"_deposit":{"created_by":7,"id":"2012279","owners":[7],"pid":{"revision_id":0,"type":"depid","value":"2012279"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012279","sets":["1713853213384:1713853295607"]},"author_link":["309","197","231"],"control_number":"2012279","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"SGLT2i and LV diastolic function","subitem_alternative_title_language":"en"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-02-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"252","bibliographicPageStart":"246","bibliographicVolumeNumber":"84","bibliographic_titles":[{"bibliographic_title":"Journal of Cardiology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: We hypothesized that the beneficial effects of sodium-glucose cotransporter-2 (SGLT2) inhibitors on diastolic function might depend on baseline left ventricular (LV) systolic function.\nMethods: To investigate the effects of SGLT2 inhibitors on LV diastolic function in patients with type 2 diabetes mellitus (T2DM), we conducted a post-hoc sub-study of the PROTECT trial, stratifying the data according to LV ejection fraction (LVEF) at baseline. After excluding patients without echocardiographic data at baseline or 24 months into the PROTECT trial, 31 and 38 patients with T2DM from the full analysis dataset of the PROTECT trial who received ipragliflozin or no SGLT2 inhibitor (control), respectively, were included. The primary endpoint was a comparison of the changes in echocardiographic parameters and NT-proBNP from baseline to 24 months between the two groups stratified according to baseline LVEF.\nResults: Differences in diastolic functional parameters (e′ and E/e′) were noted between the two groups. Among the subgroups defined according to median LVEF values, those with higher LVEF (≥60%) who received ipragliflozin appeared to have a higher e′ and lower E/e′ than did those who received the standard of care with no SGLT2 inhibitor, indicating longitudinal improvements between baseline and follow-up (p = 0.001 and 0.016, respectively).\nConclusions: Ipragliflozin generally improved LV diastolic function in patients with type 2 diabetes, the extent of this improvement might appear to vary with LV systolic function.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japanese College of Cardiology","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2024. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"09145087","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"18764738","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AN10070473","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"embargoed access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_f1cf"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.jjcc.2024.02.002"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jjcc.2024.02.002","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"414325"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"楠瀬, 賢也","creatorNameLang":"ja"},{"creatorName":"クスノセ, ケンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Kusunose, Kenya","creatorNameLang":"en"}],"familyNames":[{"familyName":"楠瀬","familyNameLang":"ja"},{"familyName":"クスノセ","familyNameLang":"ja-Kana"},{"familyName":"Kusunose","familyNameLang":"en"}],"givenNames":[{"givenName":"賢也","givenNameLang":"ja"},{"givenName":"ケンヤ","givenNameLang":"ja-Kana"},{"givenName":"Kenya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"231","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"145741/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/145741/profile-ja.html"},{"nameIdentifier":"70507649","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70507649"}]},{"creatorNames":[{"creatorName":"イマイ, タクミ","creatorNameLang":"ja"},{"creatorName":"イマイ, タクミ","creatorNameLang":"ja-Kana"},{"creatorName":"Imai, Takumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"タナカ, 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Hirotsugu","creatorNameLang":"en"}],"familyNames":[{"familyName":"山田","familyNameLang":"ja"},{"familyName":"ヤマダ","familyNameLang":"ja-Kana"},{"familyName":"Yamada","familyNameLang":"en"}],"givenNames":[{"givenName":"博胤","givenNameLang":"ja"},{"givenName":"ヒロツグ","givenNameLang":"ja-Kana"},{"givenName":"Hirotsugu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"197","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"123698/profile-ja.html","nameIdentifierScheme":"徳島大学 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Koichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2025-02-18"}],"displaytype":"detail","filename":"joc_84_4_246.pdf","filesize":[{"value":"1.8 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012279/files/joc_84_4_246.pdf"},"version_id":"3d439076-2c3e-44aa-966f-054034cf6e16"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Ipragliflozin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Type 2 diabetes mellitus","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Echocardiography","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Diastolic function","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"N-terminal pro-brain natriuretic peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NT-proBNP","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of ipragliflozin on left ventricular diastolic function in patients with type 2 diabetes : A sub-analysis of the PROTECT trial","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of ipragliflozin on left ventricular diastolic function in patients with type 2 diabetes : A sub-analysis of the PROTECT trial","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"7","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-31"},"publish_date":"2024-10-31","publish_status":"0","recid":"2012279","relation_version_is_last":true,"title":["Effects of ipragliflozin on left ventricular diastolic function in patients with type 2 diabetes : A sub-analysis of the PROTECT trial"],"weko_creator_id":"7","weko_shared_id":-1},"updated":"2025-01-29T06:59:05.608243+00:00"}