{"created":"2025-02-03T07:43:09.432249+00:00","id":2012422,"links":{},"metadata":{"_buckets":{"deposit":"ea895614-6bb1-4247-8188-ed8ead05df1d"},"_deposit":{"created_by":8,"id":"2012422","owner":"8","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2012422"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012422","sets":["1713853213384:1713853295607"]},"author_link":["1448","816","949","1567","482"],"control_number":"2012422","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2025-01-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"112","bibliographicPageStart":"104","bibliographicVolumeNumber":"157","bibliographic_titles":[{"bibliographic_title":"Journal of Pharmacological Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: The global increase in diabetes, driven by aging populations and lifestyle changes, has led to an increase in the incidence of diabetic cardiomyopathy (DCM). DCM is characterized by metabolic abnormalities, oxidative stress, and inflammation, leading to cardiac remodeling and dysfunction. Goreisan (GRS), a traditional Japanese Kampo medicine, is commonly used to treat fluid control such as edema, due to its diuretic effect. In this study, we examined the effects of GRS on DCM.\nMethods: We first established a new mouse model of DCM and then evaluated the effects of GRS on DCM using a recently developed model.\nResults: The DCM mouse model developed cardiac hypertrophy, fibrosis, and dysfunction by nine weeks, which was ameliorated by GRS administration. GRS suppressed apoptosis and protein degradation by inhibiting Akt dephosphorylation and oxidative stress in DCM mice. In contrast, no differences in inflammatory cytokine levels were observed, regardless of GRS administration.\nConclusion: GRS has potential efficacy in preventing DCM onset and development.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"},{"subitem_publisher":"Japanese Pharmacological Society","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13478648","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"13478613","subitem_source_identifier_type":"PISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Hirokazu","creatorNameLang":"en"}],"familyNames":[{"familyName":"大南","familyNameLang":"ja"},{"familyName":"オオミナミ","familyNameLang":"ja-Kana"},{"familyName":"Ohminami","familyNameLang":"en"}],"givenNames":[{"givenName":"博和","givenNameLang":"ja"},{"givenName":"ヒロカズ","givenNameLang":"ja-Kana"},{"givenName":"Hirokazu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"949","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"349363/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/349363/profile-ja.html"}]},{"creatorNames":[{"creatorName":"土屋, 浩一郎","creatorNameLang":"ja"},{"creatorName":"ツチヤ, コウイチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuchiya, Koichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"土屋","familyNameLang":"ja"},{"familyName":"ツチヤ","familyNameLang":"ja-Kana"},{"familyName":"Tsuchiya","familyNameLang":"en"}],"givenNames":[{"givenName":"浩一郎","givenNameLang":"ja"},{"givenName":"コウイチロウ","givenNameLang":"ja-Kana"},{"givenName":"Koichiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1567","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60114/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60114/profile-ja.html"},{"nameIdentifier":"70301314","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70301314"}]},{"creatorNames":[{"creatorName":"池田, 康将","creatorNameLang":"ja"},{"creatorName":"イケダ, ヤスマサ","creatorNameLang":"ja-Kana"},{"creatorName":"Ikeda, Yasumasa","creatorNameLang":"en"}],"familyNames":[{"familyName":"池田","familyNameLang":"ja"},{"familyName":"イケダ","familyNameLang":"ja-Kana"},{"familyName":"Ikeda","familyNameLang":"en"}],"givenNames":[{"givenName":"康将","givenNameLang":"ja"},{"givenName":"ヤスマサ","givenNameLang":"ja-Kana"},{"givenName":"Yasumasa","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"482","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"219499/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/219499/profile-ja.html"},{"nameIdentifier":"60432754","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=60432754"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-02-06"}],"displaytype":"detail","filename":"jphs_157_2_104.pdf","filesize":[{"value":"7.4 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012422/files/jphs_157_2_104.pdf"},"version_id":"8a12e438-f365-4eb3-8b9b-00e19bee6f88"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Kampo medicine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Diabetic cardiomyopathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Goreisan","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Goreisan suppresses cardiac remodeling and dysfunction in a new mouse model with diabetic cardiomyopathy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Goreisan suppresses cardiac remodeling and dysfunction in a new mouse model with diabetic cardiomyopathy","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"8","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-02-06"},"publish_date":"2025-02-06","publish_status":"0","recid":"2012422","relation_version_is_last":true,"title":["Goreisan suppresses cardiac remodeling and dysfunction in a new mouse model with diabetic cardiomyopathy"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2025-02-06T07:46:51.991545+00:00"}