{"created":"2025-02-12T05:52:26.165460+00:00","id":2012522,"links":{},"metadata":{"_buckets":{"deposit":"702afeaa-8d12-4e6e-8dff-f24685b95226"},"_deposit":{"created_by":51,"id":"2012522","owner":"51","owners":[51],"pid":{"revision_id":0,"type":"depid","value":"2012522"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012522","sets":["1713853213384:1713853295607"]},"author_link":["123","122","120"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-03-11","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"4335","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"Scientific Reports","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"What determines organ size has been a long-standing biological question. Lawrence et al. (2008) proposed the steepness hypothesis suggesting that the protocadherin Dachsous/Fat (Ds/Ft) system may provide some measure of dimension to the cells in relation to the gradient. In this paper we extended the model as a means of interpreting experimental results in cricket leg regeneration. We assumed that (1) Ds/Ft trans-heterodimers or trans-homodimers are redistributed during cell division and (2) growth would cease when a differential of the dimer across each cell decreases to a certain threshold. We applied our model to simulate the results obtained by leg regeneration experiments in a cricket model. The results were qualitatively consistent with the experimental data obtained for cricket legs by RNA interference methodology. Using our extended steepness model, we provided a molecular-based explanation for leg size determination even in intercalary regeneration and for organ size determination.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This work is licensed under a Creative Commons Attribution- NonCommercial-ShareAlike 3.0 Unported license. To view a copy of this license, visit","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20452322","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1038/srep04335"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1038/srep04335","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"292725"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshida, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Bando, Tetsuya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"三戸, 太郎","creatorNameLang":"ja"},{"creatorName":"ミト, タロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Mito, Taro","creatorNameLang":"en"}],"familyNames":[{"familyName":"三戸","familyNameLang":"ja"},{"familyName":"ミト","familyNameLang":"ja-Kana"},{"familyName":"Mito","familyNameLang":"en"}],"givenNames":[{"givenName":"太郎","givenNameLang":"ja"},{"givenName":"タロウ","givenNameLang":"ja-Kana"},{"givenName":"Taro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"123","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10793/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/10793/profile-ja.html"},{"nameIdentifier":"80322254","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80322254"}]},{"creatorNames":[{"creatorName":"大内, 淑代","creatorNameLang":"ja"},{"creatorName":"オオウチ, ヒデヨ","creatorNameLang":"ja-Kana"},{"creatorName":"Ohuchi, Hideyo","creatorNameLang":"en"}],"familyNames":[{"familyName":"大内","familyNameLang":"ja"},{"familyName":"オオウチ","familyNameLang":"ja-Kana"},{"familyName":"Ohuchi","familyNameLang":"en"}],"givenNames":[{"givenName":"淑代","givenNameLang":"ja"},{"givenName":"ヒデヨ","givenNameLang":"ja-Kana"},{"givenName":"Hideyo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"122","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00253229","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00253229"}]},{"creatorNames":[{"creatorName":"野地, 澄晴","creatorNameLang":"ja"},{"creatorName":"ノジ, スミハレ","creatorNameLang":"ja-Kana"},{"creatorName":"Noji, Sumihare","creatorNameLang":"en"}],"familyNames":[{"familyName":"野地","familyNameLang":"ja"},{"familyName":"ノジ","familyNameLang":"ja-Kana"},{"familyName":"Noji","familyNameLang":"en"}],"givenNames":[{"givenName":"澄晴","givenNameLang":"ja"},{"givenName":"スミハレ","givenNameLang":"ja-Kana"},{"givenName":"Sumihare","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"120","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10787/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/10787/profile-ja.html"},{"nameIdentifier":"40156211","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40156211"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-01-01"}],"displaytype":"detail","filename":"srep_4_4335.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_10","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012522/files/srep_4_4335.pdf"},"version_id":"ea7f20db-4ae8-4543-b8f3-0e842e10274a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"An extended steepness model for leg-sizedetermination based on Dachsous/Fattrans-dimer system","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"An extended steepness model for leg-sizedetermination based on Dachsous/Fattrans-dimer system","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"51","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-01-01"},"publish_date":"2024-01-01","publish_status":"0","recid":"2012522","relation_version_is_last":true,"title":["An extended steepness model for leg-sizedetermination based on Dachsous/Fattrans-dimer system"],"weko_creator_id":"51","weko_shared_id":-1},"updated":"2025-02-12T06:24:13.053500+00:00"}