| Item type |
文献 / Documents(1) |
| 公開日 |
2025-07-30 |
| アクセス権 |
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|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_2f33 |
|
資源タイプ |
book |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1007/978-4-431-55192-8_18 |
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|
関連名称 |
10.1007/978-4-431-55192-8_18 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
High Levels of Saturated Fatty Acids may Exacerbate the Pathogenesis of Primary Sjögren’s Syndrome |
| 著者 |
四釜, 洋介
石丸, 直澄
工藤, 保誠
新垣, 理恵子
Bando, Yukiko
Aki, Nanako
林, 良夫
船木, 真理
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| 抄録 |
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内容記述 |
Obesity and type 2 diabetes (T2D) are characterized by decreased insulin sensitivity and higher concentrations of free fatty acids (FFAs) in the serum. Among FFAs, saturated fatty acids, such as palmitate, have been reported to play a role in obesity-associated inflammation. Primary Sjögren’s syndrome (SS) is an autoimmune disease characterized by infiltration of inflammatory mononuclear cells and destruction of epithelial cells in salivary and lacrimal glands. Although epidemiological studies have suggested a link between primary SS and dyslipidemia or T2D, little is known about the clinical significance of elevated serum level of FFAs in primary SS. In salivary gland epithelial cells of patients with primary SS, interleukin (IL)-6 production and α-fodrin degradation are increased. IL-6 is one of the pro-inflammatory cytokines, and the cleavaged α-fodrin serves as an auto-antigen. In this study, we demonstrate that palmitate, but not unsaturated fatty acids, induces IL-6 production and α-fodrin degradation in human salivary gland epithelial cell lines. However, palmitate did not induce these responses in keratinocytes. Taken together, these results suggest that higher levels of saturated fatty acids may promote the severity of primary SS. |
| キーワード |
|
|
主題 |
Apoptosis |
| キーワード |
|
|
主題 |
Interleukin-6 |
| キーワード |
|
|
主題 |
Lipids |
| キーワード |
|
|
主題 |
Palmitate |
| キーワード |
|
|
主題 |
Sjögren’s syndrome |
| キーワード |
|
|
主題 |
α-fodrin |
| 書誌情報 |
en : Interface Oral Health Science 2014 : Innovative Research on Biosis-Abiosis Intelligent Interface
p. 217-224,
発行日 2015-09-26
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| ISBN |
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|
識別子タイプ |
ISBN |
|
|
関連識別子 |
9784431551256 |
| ISBN |
|
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|
識別子タイプ |
ISBN |
|
|
関連識別子 |
9784431551928 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
BB18131203 |
| 出版者 |
|
|
出版者 |
Springer Nature |
| 権利情報 |
|
|
権利情報 |
This chapter is distributed under the terms of the Creative Commons Attribution Noncommercial License, which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
| EID |
|
|
識別子 |
288818 |
| 言語 |
|
|
言語 |
eng |
iohs2014_217.pdf (11.2 MB)
