{"created":"2025-02-20T02:14:29.496457+00:00","id":2012658,"links":{},"metadata":{"_buckets":{"deposit":"d67b5729-5b9e-464a-bca0-bc662b75a0dc"},"_deposit":{"created_by":52,"id":"2012658","owner":"52","owners":[52],"pid":{"revision_id":0,"type":"depid","value":"2012658"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012658","sets":["1713853213384:1713853295607"]},"author_link":["182","1158","389","552","1520"],"control_number":"2012658","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-20","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"46","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Journal of NeuroEngineering and Rehabilitation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Spinal cord transection and peripheral nerve transection cause muscle atrophy and muscle fiber type conversion. It is still unknown how spinal cord transection and peripheral nerve transection each affect the differentiation of muscle fiber type conversion mechanism and muscle atrophy. The aim of our study was to evaluate the difference of muscle weight change, muscle fiber type conversion, and Peroxisome proliferator-activated receptor-γ coactivatior-1α (PGC-1α) expression brought about by spinal cord transection and by peripheral nerve transection.\nMethods: Twenty-four Wistar rats underwent surgery, the control rats underwent a laminectomy; the spinal cord injury group underwent a spinal cord transection; the denervation group underwent a sciatic nerve transection. The rats were harvested of the soleus muscle and the TA muscle at 0 week, 1 week and 2 weeks after surgery. Histological examination was assessed using hematoxylin and eosin (H&E) staining and immunofluorescent staing. Western blot was performed with 3 groups.\nResults: Both sciatic nerve transection and spinal cord transection caused muscle atrophy with the effect being more severe after sciatic nerve transection. Spinal cord transection caused a reduction in the expression of both sMHC protein and PGC-1α protein in the soleus muscle. On the other hand, sciatic nerve transection produced an increase in expression of sMHC protein and PGC-1α protein in the soleus muscle. The results of the expression of PGC-1α were expected in other words muscle atrophy after sciatic nerve transection is less than after spinal cord transection, however muscle atrophy after sciatic nerve transection was more severe than after spinal cord transection.\nConclusion: In the conclusion, spinal cord transection diminished the expression of sMHC protein and PGC-1α protein in the soleus muscle. On the other hand, sciatic nerve transection enhanced the expression of sMHC protein and PGC-1α protein in the soleus muscle.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"},{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"17430003","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA12051037","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1186/1743-0003-10-46"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1186/1743-0003-10-46","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"274212"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"東野, 恒作","creatorNameLang":"ja"},{"creatorName":"ヒガシノ, コウサク","creatorNameLang":"ja-Kana"},{"creatorName":"Higashino, Kousaku","creatorNameLang":"en"}],"familyNames":[{"familyName":"東野","familyNameLang":"ja"},{"familyName":"ヒガシノ","familyNameLang":"ja-Kana"},{"familyName":"Higashino","familyNameLang":"en"}],"givenNames":[{"givenName":"恒作","givenNameLang":"ja"},{"givenName":"コウサク","givenNameLang":"ja-Kana"},{"givenName":"Kousaku","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"182","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80380129","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80380129"}]},{"creatorNames":[{"creatorName":"松浦, 哲也","creatorNameLang":"ja"},{"creatorName":"マツウラ, テツヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuura, Tetsuya","creatorNameLang":"en"}],"familyNames":[{"familyName":"松浦","familyNameLang":"ja"},{"familyName":"マツウラ","familyNameLang":"ja-Kana"},{"familyName":"Matsuura","familyNameLang":"en"}],"givenNames":[{"givenName":"哲也","givenNameLang":"ja"},{"givenName":"テツヤ","givenNameLang":"ja-Kana"},{"givenName":"Tetsuya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1158","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60679/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60679/profile-ja.html"},{"nameIdentifier":"30359913","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30359913"}]},{"creatorNames":[{"creatorName":"Suganuma, Katsuyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"油形, 公則","creatorNameLang":"ja"},{"creatorName":"ユカタ, キミノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Yukata, Kiminori","creatorNameLang":"en"}],"familyNames":[{"familyName":"油形","familyNameLang":"ja"},{"familyName":"ユカタ","familyNameLang":"ja-Kana"},{"familyName":"Yukata","familyNameLang":"en"}],"givenNames":[{"givenName":"公則","givenNameLang":"ja"},{"givenName":"キミノリ","givenNameLang":"ja-Kana"},{"givenName":"Kiminori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"389","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40564430","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40564430"}]},{"creatorNames":[{"creatorName":"西庄, 俊彦","creatorNameLang":"ja"},{"creatorName":"ニシショウ, トシヒコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nishisho, Toshihiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"西庄","familyNameLang":"ja"},{"familyName":"ニシショウ","familyNameLang":"ja-Kana"},{"familyName":"Nishisho","familyNameLang":"en"}],"givenNames":[{"givenName":"俊彦","givenNameLang":"ja"},{"givenName":"トシヒコ","givenNameLang":"ja-Kana"},{"givenName":"Toshihiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"552","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"244268/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/244268/profile-ja.html"},{"nameIdentifier":"40444723","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40444723"}]},{"creatorNames":[{"creatorName":"安井, 夏生","creatorNameLang":"ja"},{"creatorName":"ヤスイ, ナツオ","creatorNameLang":"ja-Kana"},{"creatorName":"Yasui, Natsuo","creatorNameLang":"en"}],"familyNames":[{"familyName":"安井","familyNameLang":"ja"},{"familyName":"ヤスイ","familyNameLang":"ja-Kana"},{"familyName":"Yasui","familyNameLang":"en"}],"givenNames":[{"givenName":"夏生","givenNameLang":"ja"},{"givenName":"ナツオ","givenNameLang":"ja-Kana"},{"givenName":"Natsuo","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1520","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60032/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60032/profile-ja.html"},{"nameIdentifier":"00157984","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00157984"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-03-11"}],"displaytype":"detail","filename":"jner_10_46.pdf","filesize":[{"value":"2 MB"}],"format":"application/pdf","license_note":"CC BY 2.0","licensetype":"license_note","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012658/files/jner_10_46.pdf"},"version_id":"db12cb24-209f-4535-9eda-c2506b35975b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Muscle atrophy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Muscle fiver type conversion","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Spinal cord transection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Peripheral nerve transection","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rat","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Early changes in muscle atrophy and muscle fiber type conversion after spinal cord transection and peripheral nerve transection in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Early changes in muscle atrophy and muscle fiber type conversion after spinal cord transection and peripheral nerve transection in rats","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"52","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-03-11"},"publish_date":"2025-03-11","publish_status":"0","recid":"2012658","relation_version_is_last":true,"title":["Early changes in muscle atrophy and muscle fiber type conversion after spinal cord transection and peripheral nerve transection in rats"],"weko_creator_id":"52","weko_shared_id":-1},"updated":"2025-03-17T04:34:04.618383+00:00"}