{"created":"2025-02-20T04:03:18.461375+00:00","id":2012661,"links":{},"metadata":{"_buckets":{"deposit":"845d1f00-6e6d-4fc8-861c-6cf4317e746f"},"_deposit":{"created_by":52,"id":"2012661","owner":"52","owners":[52],"pid":{"revision_id":0,"type":"depid","value":"2012661"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012661","sets":["1713853213384:1713853295607"]},"author_link":["573","396","1623","1622"],"control_number":"2012661","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-11-13","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"135","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"Journal of Neuroinflammation","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Inflammatory responses in the cerebrospinal fluid (CSF) of patients with sporadic Creutzfeldt-Jakob disease (sCJD) remain elusive.\nMethods: We conducted a case-control study, in which 14 patients with sCJD, 14 with noninflammatory neurological disorders, and 14 with autoimmune encephalitis were enrolled. We used the suspension array system to measure the concentrations of 27 cytokines in CSF. The cytokine titers of the three groups were compared, and the correlation between the relevant cytokine titers and clinical parameters was investigated in the patients with sCJD.\nResults: Levels of the two cytokines interleukin (IL)-1 receptor antagonist and IL-17 were significantly elevated in the patients with sCJD compared with those in the patients with noninflammatory neurological disorders: IL-17 levels in sCJD were approximately ten times higher than in the noninflammatory neurological disorders (mean, 35.46 vs. 3.45 pg/ml; P < 0.001) but comparable to that in encephalitis (mean, 32.16 pg/ml). In contrast, levels of classical proinflammatory cytokines such as IL-12(p70) and tumor necrosis factor-α were increased only in encephalitis. Although not significant, IL-17 titers tended to be higher in the patients with shorter disease duration before CSF sampling (r = −0.452; P = 0.104) and in those with lower CSF total protein concentrations (r = −0.473; P = 0.086).\nConclusions: IL-17 is significantly increased in CSF in sCJD, which can be an early event in the pathogenesis of sCJD.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"BioMed Central","subitem_publisher_language":"en"},{"subitem_publisher":"Springer Nature","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"17422094","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA12051048","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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Tatsuhiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"和泉, 唯信","creatorNameLang":"ja"},{"creatorName":"イズミ, ユイシン","creatorNameLang":"ja-Kana"},{"creatorName":"Izumi, Yuishin","creatorNameLang":"en"}],"familyNames":[{"familyName":"和泉","familyNameLang":"ja"},{"familyName":"イズミ","familyNameLang":"ja-Kana"},{"familyName":"Izumi","familyNameLang":"en"}],"givenNames":[{"givenName":"唯信","givenNameLang":"ja"},{"givenName":"ユイシン","givenNameLang":"ja-Kana"},{"givenName":"Yuishin","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1623","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60227/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60227/profile-ja.html"},{"nameIdentifier":"10335812","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10335812"}]},{"creatorNames":[{"creatorName":"梶, 龍兒","creatorNameLang":"ja"},{"creatorName":"カジ, リュウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kaji, Ryuji","creatorNameLang":"en"}],"familyNames":[{"familyName":"梶","familyNameLang":"ja"},{"familyName":"カジ","familyNameLang":"ja-Kana"},{"familyName":"Kaji","familyNameLang":"en"}],"givenNames":[{"givenName":"龍兒","givenNameLang":"ja"},{"givenName":"リュウジ","givenNameLang":"ja-Kana"},{"givenName":"Ryuji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1622","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60224/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60224/profile-ja.html"},{"nameIdentifier":"00214304","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00214304"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-03-11"}],"displaytype":"detail","filename":"jni_10_135.pdf","filesize":[{"value":"212 KB"}],"format":"application/pdf","license_note":"CC BY 2.0","licensetype":"license_note","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012661/files/jni_10_135.pdf"},"version_id":"2c9c3d56-d661-4dbd-bdbb-3e9464255b84"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Creutzfeldt-Jakob disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytokines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Interleukin-17","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Neurodegeneration","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Increased interleukin-17 in the cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease : a case-control study of rapidly progressive dementia","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Increased interleukin-17 in the cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease : a case-control study of rapidly progressive dementia","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"52","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-03-11"},"publish_date":"2025-03-11","publish_status":"0","recid":"2012661","relation_version_is_last":true,"title":["Increased interleukin-17 in the cerebrospinal fluid in sporadic Creutzfeldt-Jakob disease : a case-control study of rapidly progressive dementia"],"weko_creator_id":"52","weko_shared_id":-1},"updated":"2025-03-17T04:36:15.863524+00:00"}