| Item type |
文献 / Documents(1) |
| 公開日 |
2025-07-17 |
| アクセス権 |
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アクセス権 |
open access |
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アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1186/1743-7075-11-32 |
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関連名称 |
10.1186/1743-7075-11-32 |
| 出版タイプ |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
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タイトル |
Sudachitin, a polymethoxylated flavone, improves glucose and lipid metabolism by increasing mitochondrial biogenesis in skeletal muscle |
| 著者 |
堤, 理恵
Yoshida, Tomomi
Nii, Yoshitaka
Okahisa, Naoki
Iwata, Shinya
津嘉山, 正夫
Hashimoto, Rei
Taniguchi, Yasuko
阪上, 浩
Hosaka, Toshio
首藤, 恵泉
酒井, 徹
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| 抄録 |
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内容記述 |
Background: Obesity is a major risk factor for insulin resistance, type 2 diabetes, and stroke. Flavonoids are effective antioxidants that protect against these chronic diseases. In this study, we evaluated the effects of sudachitin, a polymethoxylated flavonoid found in the skin of the Citrus sudachi fruit, on glucose, lipid, and energy metabolism in mice with high-fat diet-induced obesity and db/db diabetic mice. In our current study, we show that sudachitin improves metabolism and stimulates mitochondrial biogenesis, thereby increasing energy expenditure and reducing weight gain.
Methods: C57BL/6 J mice fed a high-fat diet (40% fat) and db/db mice fed a normal diet were treated orally with 5 mg/kg sudachitin or vehicle for 12 weeks. Following treatment, oxygen expenditure was assessed using indirect calorimetry, while glucose tolerance, insulin sensitivity, and indices of dyslipidemia were assessed by serum biochemistry. Quantitative polymerase chain reaction was used to determine the effect of sudachitin on the transcription of key metabolism-regulating genes in the skeletal muscle, liver, and white and brown adipose tissues. Primary myocytes were also prepared to examine the signaling mechanisms targeted by sudachitin in vitro.
Results: Sudachitin improved dyslipidemia, as evidenced by reduction in triglyceride and free fatty acid levels, and improved glucose tolerance and insulin resistance. It also enhanced energy expenditure and fatty acid β-oxidation by increasing mitochondrial biogenesis and function. The in vitro assay results suggest that sudachitin increased Sirt1 and PGC-1α expression in the skeletal muscle.
Conclusions: Sudachitin may improve dyslipidemia and metabolic syndrome by improving energy metabolism. Furthermore, it also induces mitochondrial biogenesis to protect against metabolic disorders. |
| キーワード |
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主題 |
Sudachitin |
| キーワード |
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主題 |
Glucose metabolism |
| キーワード |
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主題 |
Lipid metabolism |
| キーワード |
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主題 |
Mitochondria |
| 書誌情報 |
en : Nutrition & Metabolism
巻 11,
p. 32,
発行日 2014-07-04
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| 収録物ID |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
17437075 |
| 出版者 |
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出版者 |
BioMed Central |
| 出版者 |
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出版者 |
Springer Nature |
| 権利情報 |
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権利情報 |
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
| EID |
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|
識別子 |
285182 |
| 言語 |
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言語 |
eng |
nme_11_32.pdf (1.5 MB)
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