{"created":"2025-03-03T01:59:23.196661+00:00","id":2012772,"links":{},"metadata":{"_buckets":{"deposit":"1c8fd860-4f09-4a4a-8129-abc6de311c16"},"_deposit":{"created_by":121,"id":"2012772","owner":"121","owners":[121],"pid":{"revision_id":0,"type":"depid","value":"2012772"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012772","sets":["1713853213384:1713853295607"]},"author_link":["863","1196"],"control_number":"2012772","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-06-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"1101","bibliographicPageStart":"1090","bibliographicVolumeNumber":"88","bibliographic_titles":[{"bibliographic_title":"Bioscience, Biotechnology, and Biochemistry","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The process of apoptotic cell clearance by phagocytes, known as efferocytosis, plays an essential role in maintaining homeostasis. Defects in efferocytosis can lead to inflammatory diseases such as atherosclerosis and autoimmune disorders. Therefore, the maintenance and promotion of efferocytosis are considered crucial for preventing these diseases. In this study, we observed that resveratrol, a representative functional food ingredient, and its glycoside, piceid, promoted efferocytosis in both human THP-1 macrophages differentiated with phorbol 12-myristate 13-acetate and peritoneal macrophages from thioglycolate-elicited mice. Resveratrol and piceid significantly increased mRNA expression and protein secretion of MFG-E8 in THP-1 macrophages. Furthermore, the activation of efferocytosis and the increment in MFG-E8 protein secretion caused by resveratrol or piceid treatment were canceled by MFG-E8 knockdown in THP-1 macrophages. In conclusion, we have demonstrated for the first time that resveratrol and piceid promote efferocytosis through the upregulation of MFG-E8 excretion in human THP-1 macrophages.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japan Society for Bioscience, Biotechnology, and Agrochemistry","subitem_publisher_language":"en"},{"subitem_publisher":"Oxford University Press","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"13476947","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"09168451","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"AA10824164","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1093/bbb/zbae079"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1093/bbb/zbae079","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"411500"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wang, Jing","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hashimoto, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hiemori-Kondo, Miki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"中本, 晶子","creatorNameLang":"ja"},{"creatorName":"ナカモト, アキコ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakamoto, Akiko","creatorNameLang":"en"}],"familyNames":[{"familyName":"中本","familyNameLang":"ja"},{"familyName":"ナカモト","familyNameLang":"ja-Kana"},{"familyName":"Nakamoto","familyNameLang":"en"}],"givenNames":[{"givenName":"晶子","givenNameLang":"ja"},{"givenName":"アキコ","givenNameLang":"ja-Kana"},{"givenName":"Akiko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"863","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"323760/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/323760/profile-ja.html"},{"nameIdentifier":"90803536","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=90803536"}]},{"creatorNames":[{"creatorName":"酒井, 徹","creatorNameLang":"ja"},{"creatorName":"サカイ, トオル","creatorNameLang":"ja-Kana"},{"creatorName":"Sakai, Tohru","creatorNameLang":"en"}],"familyNames":[{"familyName":"酒井","familyNameLang":"ja"},{"familyName":"サカイ","familyNameLang":"ja-Kana"},{"familyName":"Sakai","familyNameLang":"en"}],"givenNames":[{"givenName":"徹","givenNameLang":"ja"},{"givenName":"トオル","givenNameLang":"ja-Kana"},{"givenName":"Tohru","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1196","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60693/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60693/profile-ja.html"},{"nameIdentifier":"40274196","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40274196"}]},{"creatorNames":[{"creatorName":"Ye, Wenxiu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Abe-Kanoh, Naomi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-03-19"}],"displaytype":"detail","filename":"bbb_88_9_1090.pdf","filesize":[{"value":"939 KB"}],"format":"application/pdf","licensetype":"license_3","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012772/files/bbb_88_9_1090.pdf"},"version_id":"9fa565ed-2ad0-4970-9359-df78564c9e47"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"macrophage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"efferocytosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"resveratrol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"anti-inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"MFG-E8","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Resveratrol and piceid enhance efferocytosis by increasing the secretion of MFG-E8 in human THP-1 macrophages","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Resveratrol and piceid enhance efferocytosis by increasing the secretion of MFG-E8 in human THP-1 macrophages","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"121","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-03-19"},"publish_date":"2025-03-19","publish_status":"0","recid":"2012772","relation_version_is_last":true,"title":["Resveratrol and piceid enhance efferocytosis by increasing the secretion of MFG-E8 in human THP-1 macrophages"],"weko_creator_id":"121","weko_shared_id":-1},"updated":"2025-03-19T00:49:10.711422+00:00"}