{"created":"2025-03-03T05:31:52.171240+00:00","id":2012778,"links":{},"metadata":{"_buckets":{"deposit":"97778b5e-10c5-4766-a720-e36744f3a9f4"},"_deposit":{"created_by":121,"id":"2012778","owner":"121","owners":[121],"pid":{"revision_id":0,"type":"depid","value":"2012778"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012778","sets":["1713853213384:1713853295607"]},"author_link":["226"],"control_number":"2012778","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-08","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"116180","bibliographicVolumeNumber":"273","bibliographic_titles":[{"bibliographic_title":"Ecotoxicology and Environmental Safety","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Microplastics (MPs)/nanoplastics (NPs), as a source and vector of pathogenic bacteria, are widely distributed in the natural environments. Here, we investigated the combined effects of polystyrene NPs (PS-NPs) and lipopolysaccharides (LPS) on testicular function in mice for the first time. 24 male mice were randomly assigned into 4 groups, control, PS-NPs, LPS, and PS-NPs + LPS, respectively. Histological alterations of the testes were observed in mice exposed to PS-NPs, LPS or PS-NPs + LPS. Total sperm count, the levels of testosterone in plasma and testes, the expression levels of steroidogenic acute regulatory (StAR) decreased more remarkable in testes of mice treated with PS-NPs and LPS than the treatment with LPS or PS-NPs alone. Compared with PS-NPs treatment, LPS treatment induced more sever inflammatory response in testes of mice. Moreover, PS-NPs combined with LPS treatment increased the expression of these inflammatory factors more significantly than LPS treatment alone. In addition, PS-NPs or LPS treatment induced oxidative stress in testes of mice, but their combined effect is not significantly different from LPS treatment alone. These results suggest that PS-NPs exacerbate LPS-induced testicular dysfunction. Our results provide new evidence for the threats to male reproductive function induced by both NPs and bacterial infection in human health.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"01476513","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"10902414","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA1154269X","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA00179452","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.ecoenv.2024.116180"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.ecoenv.2024.116180","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"412994"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Li, Yanli","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Liu, Yingqi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Chen, Yanhong","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"姚, 陳娟","creatorNameLang":"ja"},{"creatorName":"ヤオ, チェンジャン","creatorNameLang":"ja-Kana"},{"creatorName":"Yao, Chenjuan","creatorNameLang":"en"}],"familyNames":[{"familyName":"姚","familyNameLang":"ja"},{"familyName":"ヤオ","familyNameLang":"ja-Kana"},{"familyName":"Yao","familyNameLang":"en"}],"givenNames":[{"givenName":"陳娟","givenNameLang":"ja"},{"givenName":"チェンジャン","givenNameLang":"ja-Kana"},{"givenName":"Chenjuan","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"226","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"140893/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/140893/profile-ja.html"},{"nameIdentifier":"20432750","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20432750"}]},{"creatorNames":[{"creatorName":"Yu, Shali","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Qu, Jianhua","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Chen, Gang","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Wei, Haiyan","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-03-25"}],"displaytype":"detail","filename":"ecoenv_273_116180.pdf","filesize":[{"value":"7.1 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012778/files/ecoenv_273_116180.pdf"},"version_id":"32ca00bf-9129-4d8e-b56d-3d233ee3ab65"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Nanoplastics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipopolysaccharide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Testis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Inflammation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Testosterone biosynthesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Combined effects of polystyrene nanoplastics and lipopolysaccharide on testosterone biosynthesis and inflammation in mouse testis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Combined effects of polystyrene nanoplastics and lipopolysaccharide on testosterone biosynthesis and inflammation in mouse testis","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"121","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-03-25"},"publish_date":"2025-03-25","publish_status":"0","recid":"2012778","relation_version_is_last":true,"title":["Combined effects of polystyrene nanoplastics and lipopolysaccharide on testosterone biosynthesis and inflammation in mouse testis"],"weko_creator_id":"121","weko_shared_id":-1},"updated":"2025-03-25T05:58:24.413059+00:00"}