{"created":"2025-03-05T00:15:30.973643+00:00","id":2012794,"links":{},"metadata":{"_buckets":{"deposit":"e51556aa-4d63-4ff8-9a16-e6f48243b8bb"},"_deposit":{"created_by":52,"id":"2012794","owner":"52","owners":[52],"pid":{"revision_id":0,"type":"depid","value":"2012794"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012794","sets":["1713853213384:1713853295607"]},"author_link":["1188"],"control_number":"2012794","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-01-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"2299","bibliographicPageStart":"2282","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"Chemical Science","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Proper folding is essential for the biological functions of all proteins. The folding process is intrinsically error-prone, and the misfolding of a polypeptide chain can cause the formation of toxic aggregates related to pathological outcomes such as neurodegenerative disease and diabetes. Chaperones and some enzymes are involved in the cellular proteostasis systems that assist polypeptide folding to diminish the risk of aggregation. Elucidating the molecular mechanisms of chaperones and related enzymes is important for understanding proteostasis systems and protein misfolding- and aggregation-related pathophysiology. Furthermore, mechanistic studies of chaperones and related enzymes provide important clues to designing chemical mimics, or chemical chaperones, that are potentially useful for recovering proteostasis activities as therapeutic approaches for treating and preventing protein misfolding-related diseases. In this Perspective, we provide a comprehensive overview of the latest understanding of the folding-promotion mechanisms by chaperones and oxidoreductases and recent progress in the development of chemical mimics that possess activities comparable to enzymes, followed by a discussion of future directions.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Royal Society of Chemistry","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"20416539","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1039/d3sc05781j"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1039/d3sc05781j","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"412432"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Muraoka, Takahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Okumura, Masaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"齋尾, 智英","creatorNameLang":"ja"},{"creatorName":"サイオ, トモヒデ","creatorNameLang":"ja-Kana"},{"creatorName":"Saio, Tomohide","creatorNameLang":"en"}],"familyNames":[{"familyName":"齋尾","familyNameLang":"ja"},{"familyName":"サイオ","familyNameLang":"ja-Kana"},{"familyName":"Saio","familyNameLang":"en"}],"givenNames":[{"givenName":"智英","givenNameLang":"ja"},{"givenName":"トモヒデ","givenNameLang":"ja-Kana"},{"givenName":"Tomohide","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1188","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"371222/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/371222/profile-ja.html"},{"nameIdentifier":"80740802","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=80740802"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-03-14"}],"displaytype":"detail","filename":"cs_15_7_2282.pdf","filesize":[{"value":"2 MB"}],"format":"application/pdf","licensetype":"license_6","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012794/files/cs_15_7_2282.pdf"},"version_id":"4f258cf0-8a98-47f6-97f1-73cce9b72340"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Enzymatic and synthetic regulation of polypeptide folding","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Enzymatic and synthetic regulation of polypeptide folding","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"52","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-03-14"},"publish_date":"2025-03-14","publish_status":"0","recid":"2012794","relation_version_is_last":true,"title":["Enzymatic and synthetic regulation of polypeptide folding"],"weko_creator_id":"52","weko_shared_id":-1},"updated":"2025-03-14T06:54:54.852592+00:00"}