| Item type |
文献 / Documents(1) |
| 公開日 |
2025-05-19 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1016/j.molmet.2024.101968 |
|
|
関連名称 |
10.1016/j.molmet.2024.101968 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism |
| 著者 |
野村, 和弘
Kinoshita, Shinichi
Mizusaki, Nao
Senga, Yoko
Sasaki, Tsutomu
Kitamura, Tadahiro
阪上, 浩
Emi, Aki
Hosooka, Tetsuya
Matsuo, Masahiro
Okamura, Hitoshi
Amo, Taku
Wolf, Alexander M.
Kamimura, Naomi
Ohta, Shigeo
Itoh, Tomoo
Hayashi, Yoshitake
Kiyonari, Hiroshi
Krook, Anna
Zierath, Juleen R.
Kasuga, Masato
Ogawa, Wataru
|
| 抄録 |
|
|
内容記述 |
The transcriptional coactivator PGC-1α has been implicated in the regulation of multiple metabolic processes. However, the previously reported metabolic phenotypes of mice deficient in PGC-1α have been inconsistent. PGC-1α exists as multiple isoforms, including variants transcribed from an alternative first exon. We show here that alternative PGC-1α variants are the main entity that increases PGC-1α during exercise. These variants, unlike the canonical isoform of PGC-1α, are robustly upregulated in human skeletal muscle after exercise. Furthermore, the extent of this upregulation correlates with oxygen consumption. Mice lacking these variants manifest impaired energy expenditure during exercise, leading to the development of obesity and hyperinsulinemia. The alternative variants are also upregulated in brown adipose tissue in response to cold exposure, and mice lacking these variants are intolerant of a cold environment. Our findings thus indicate that an increase in PGC-1α expression, attributable mostly to upregulation of alternative variants, is pivotal for adaptive enhancement of energy expenditure and heat production and thereby essential for the regulation of whole-body energy metabolism. |
| キーワード |
|
|
主題 |
PGC-1a |
| キーワード |
|
|
主題 |
Skeletal muscle |
| キーワード |
|
|
主題 |
Exercise |
| キーワード |
|
|
主題 |
Obesity |
| キーワード |
|
|
主題 |
Diabetes |
| キーワード |
|
|
主題 |
Energy expenditure |
| 書誌情報 |
en : Molecular Metabolism
巻 86,
p. 101968,
発行日 2024-06-15
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
22128778 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| EID |
|
|
識別子 |
410945 |
| 言語 |
|
|
言語 |
eng |
mome_86_101968.pdf (4.4 MB)
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