{"created":"2025-03-10T23:03:19.028278+00:00","id":2012859,"links":{},"metadata":{"_buckets":{"deposit":"4c7a1959-be2c-42cd-8571-148625a07647"},"_deposit":{"created_by":8,"id":"2012859","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2012859"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012859","sets":["1713853213384:1713853295607"]},"author_link":["1409","1127","1139"],"control_number":"2012859","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2025-03-13","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageStart":"103724","bibliographicVolumeNumber":"114","bibliographic_titles":[{"bibliographic_title":"Journal of Pharmaceutical Sciences","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Lipid accumulation inhibition is a pivotal focus for anti-obesity drugs. α-Tocopheryl succinate (TS) is a derivative of α-tocopherol (T) that inhibits lipid accumulation, making it a propitious candidate for an anti-obesity agent. However, cytotoxicity of TS limits its application. Reactive oxygen species produced by TS are responsible for the cytotoxicity, which can be mitigated by T. Herein, we evaluated the effect of a liposomal formulation co-encapsulating TS and T (TS/T-lipo) on obesity. We prepared TS/T-lipo and evaluated the resultant cytotoxicity and lipid accumulation inhibition effect in vitro. TS/T-lipo showed a significant inhibitory effect on lipid accumulation without cytotoxicity. The inhibitory effect on lipid accumulation is likely due to upregulation of Uncoupling Protein 1, which causes lipid consumption. Moreover, we evaluated the effect of TS/T-lipo on a high-fat diet-induced obese mouse model and found that body weight significantly decreased in the TS/T-lipo group without elevation of liver toxicity or blood glucose levels. Additionally, increased glycerol serum levels are suggestive of increased lipolysis upon treatment with TS/T-lipo. Histological analysis supports inhibition of lipid accumulation by treatment with TS/T-lipo. Taken together, this evidence demonstrates that co-administration of TS/T can reduce cytotoxicity and may be a promising candidate for an anti-obesity drug.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Pharmacists Association","subitem_publisher_language":"en"},{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2025. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"15206017","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"00223549","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"AA00704450","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"embargoed access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_f1cf"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1016/j.xphs.2025.103724"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.xphs.2025.103724","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"416978"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Seto, Yuika","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tapu, S. M. Tafsirul Alam","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kugisaki, Natsuho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"米田, 晋太朗","creatorNameLang":"ja"},{"creatorName":"ヨネダ, シンタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoneda, Shintaro","creatorNameLang":"en"}],"familyNames":[{"familyName":"米田","familyNameLang":"ja"},{"familyName":"ヨネダ","familyNameLang":"ja-Kana"},{"familyName":"Yoneda","familyNameLang":"en"}],"givenNames":[{"givenName":"晋太朗","givenNameLang":"ja"},{"givenName":"シンタロウ","givenNameLang":"ja-Kana"},{"givenName":"Shintaro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1409","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"406068/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/406068/profile-ja.html"},{"nameIdentifier":"31001513","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=31001513"}]},{"creatorNames":[{"creatorName":"山﨑, 尚志","creatorNameLang":"ja"},{"creatorName":"ヤマザキ, ナオシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamazaki, Naoshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"山﨑","familyNameLang":"ja"},{"familyName":"ヤマザキ","familyNameLang":"ja-Kana"},{"familyName":"Yamazaki","familyNameLang":"en"}],"givenNames":[{"givenName":"尚志","givenNameLang":"ja"},{"givenName":"ナオシ","givenNameLang":"ja-Kana"},{"givenName":"Naoshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1127","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60619/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60619/profile-ja.html"},{"nameIdentifier":"20271083","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=20271083"}]},{"creatorNames":[{"creatorName":"小暮, 健太朗","creatorNameLang":"ja"},{"creatorName":"コグレ, ケンタロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kogure, Kentaro","creatorNameLang":"en"}],"familyNames":[{"familyName":"小暮","familyNameLang":"ja"},{"familyName":"コグレ","familyNameLang":"ja-Kana"},{"familyName":"Kogure","familyNameLang":"en"}],"givenNames":[{"givenName":"健太朗","givenNameLang":"ja"},{"givenName":"ケンタロウ","givenNameLang":"ja-Kana"},{"givenName":"Kentaro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1139","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60638/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60638/profile-ja.html"},{"nameIdentifier":"70262540","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70262540"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2026-03-13"}],"displaytype":"detail","filename":"xphs_114_5_103724.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012859/files/xphs_114_5_103724.pdf"},"version_id":"5dbabfb0-4f20-417a-b51d-d08554add016"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Liposome","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"α-Tocopherol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"α-Tocopheryl succinate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Obesity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Lipid accumulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Liposomal formulation co-encapsulating α-tocopheryl succinate and α-tocopherol ameliorates high-fat diet-induced obesity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Liposomal formulation co-encapsulating α-tocopheryl succinate and α-tocopherol ameliorates high-fat diet-induced obesity","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"8","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-03-28"},"publish_date":"2025-03-28","publish_status":"0","recid":"2012859","relation_version_is_last":true,"title":["Liposomal formulation co-encapsulating α-tocopheryl succinate and α-tocopherol ameliorates high-fat diet-induced obesity"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2025-03-28T09:23:21.125422+00:00"}