{"created":"2025-03-11T00:49:24.878021+00:00","id":2012862,"links":{},"metadata":{"_buckets":{"deposit":"6df5e21d-ba77-41cb-81df-cfc50ff53123"},"_deposit":{"created_by":51,"id":"2012862","owner":"51","owners":[51],"pid":{"revision_id":0,"type":"depid","value":"2012862"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012862","sets":["1713853213384:1713853295607"]},"author_link":["1335","731","1145"],"control_number":"2012862","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-09-28","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageStart":"1271","bibliographicVolumeNumber":"16","bibliographic_titles":[{"bibliographic_title":"Pharmaceutics","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: Acrylamide polymers with zwitterionic carboxybetaine (CB) side groups have attracted attention as stealth polymers that do not induce antibodies when conjugated to proteins. However, they induce antibodies when modified onto liposomes. We hypothesized that antibodies are produced against polymer backbones rather than CB side groups. Objectives: In this study, we designed and synthesized a polymer employing CB in its main chain, poly(N-acetic acid-N-methyl-propyleneimine) (PAMPI), and evaluated the blood retention of PAMPI-modified liposomes in mice. Results: The non-fouling nature of PAMPI-modified liposomes estimated from serum protein adsorption was found to be not inferior to PCB- and PEG-modified liposomes. However, to our surprise, the PAMPI-modified liposomes showed an instantaneous clearance less than 1 h post-injection, comparable to the naked liposomes. Conclusions: The extent of the blood retention of polymer-modified liposomes cannot be predicted by their susceptibility to serum protein adsorption and semi-flexible conformation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"MDPI","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"19994923","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open 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polymer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"liposome","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A Stealthiness Evaluation of Main Chain Carboxybetaine Polymer Modified into Liposome","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A Stealthiness Evaluation of Main Chain Carboxybetaine Polymer Modified into Liposome","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"51","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-01-01"},"publish_date":"2024-01-01","publish_status":"0","recid":"2012862","relation_version_is_last":true,"title":["A Stealthiness Evaluation of Main Chain Carboxybetaine Polymer Modified into Liposome"],"weko_creator_id":"51","weko_shared_id":-1},"updated":"2025-03-18T06:55:17.627639+00:00"}