{"created":"2025-03-17T03:46:04.901973+00:00","id":2012881,"links":{},"metadata":{"_buckets":{"deposit":"b9c5ac74-5168-40b1-906c-311cf0c1e629"},"_deposit":{"created_by":8,"id":"2012881","owners":[8],"pid":{"revision_id":0,"type":"depid","value":"2012881"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02012881","sets":["1713853213384:1713853295607"]},"author_link":["751"],"control_number":"2012881","item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-07-14","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"2377404","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Molecular & Cellular Oncology","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Inhibition of autophagy is an important strategy in cancer therapy. However, prolonged inhibition of certain autophagies in established cancer cells may increase therapeutic resistance, though the underlying mechanisms of its induction and enhancement remain unclear. This study sought to elucidate the mechanisms of therapeutic resistance through repeated autophagy inhibition and amino acid deprivation (AD) in an in vitro model of in vivo chronic nutrient deprivation associated with cancer cell treatment. In the human cervical cancer cell line HeLa and human breast cancer cell line MCF-7, initial extracellular AD induced the immediate expression of endosomal microautophagy (eMI). However, repeated inhibition of eMI with U18666A and extracellular AD induced macroautophagy (MA) to compensate for reduced eMI, simultaneously decreasing cytotoxicity. Here, hyperphosphorylated JNK was transformed into a hypophosphorylated state, suggesting conversion of the cell death signal to a survival signal. In a nutrient medium, cell death could not be induced by MA inhibition. However, since LAT1 inhibitors induce intracellular AD, combining them with MA and eMI inhibitors successfully promoted cell death in resistant cells. Our study identified a novel therapeuic approach for promoting cell death and addressing therapeutic resistance in cancers under autophagy-inhibitor treatment.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Taylor & Francis","subitem_publisher_language":"en"}]},"item_10001_rights_15":{"attribute_name":"権利情報","attribute_value_mlt":[{"subitem_rights":"This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.","subitem_rights_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"23723556","subitem_source_identifier_type":"EISSN"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.1080/23723556.2024.2377404"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1080/23723556.2024.2377404","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"417133"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Fukui, Takahito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Yabumoto, Manami","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishida, Misuzu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirokawa, Shiori","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sato, Riho","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kurisu, Taichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakai, Miyu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hassan, Md. Abul","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岸本, 幸治","creatorNameLang":"ja"},{"creatorName":"キシモト, コウジ","creatorNameLang":"ja-Kana"},{"creatorName":"Kishimoto, Koji","creatorNameLang":"en"}],"familyNames":[{"familyName":"岸本","familyNameLang":"ja"},{"familyName":"キシモト","familyNameLang":"ja-Kana"},{"familyName":"Kishimoto","familyNameLang":"en"}],"givenNames":[{"givenName":"幸治","givenNameLang":"ja"},{"givenName":"コウジ","givenNameLang":"ja-Kana"},{"givenName":"Koji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"751","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"289783/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/289783/profile-ja.html"},{"nameIdentifier":"50280699","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50280699"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-04-11"}],"displaytype":"detail","filename":"mco_11_1_2377404.pdf","filesize":[{"value":"4.6 MB"}],"format":"application/pdf","licensetype":"license_0","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2012881/files/mco_11_1_2377404.pdf"},"version_id":"07516b90-c106-4283-9d04-4e51ce8c68bd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Amino acid deprivation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"amino acid transporter","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"autophagy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chemoresistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Amino acid deprivation in cancer cells with compensatory autophagy induction increases sensitivity to autophagy inhibitors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Amino acid deprivation in cancer cells with compensatory autophagy induction increases sensitivity to autophagy inhibitors","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"8","path":["1713853295607"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-04-11"},"publish_date":"2025-04-11","publish_status":"0","recid":"2012881","relation_version_is_last":true,"title":["Amino acid deprivation in cancer cells with compensatory autophagy induction increases sensitivity to autophagy inhibitors"],"weko_creator_id":"8","weko_shared_id":-1},"updated":"2025-04-28T06:59:04.215117+00:00"}