{"created":"2025-04-15T01:13:35.340154+00:00","id":2013193,"links":{},"metadata":{"_buckets":{"deposit":"33311bc7-9693-4203-8fa4-43f155f49382"},"_deposit":{"created_by":48,"id":"2013193","owner":"48","owners":[48],"pid":{"revision_id":0,"type":"depid","value":"2013193"},"status":"published"},"_oai":{"id":"oai:tokushima-u.repo.nii.ac.jp:02013193","sets":["1713853213384:1713853296295:1716267876683:1716268551628"]},"author_link":["711","992","1557","1546","519","960","1559","1568","1548"],"control_number":"2013193","item_10001_alternative_title_1":{"attribute_name":"タイトル別表記","attribute_value_mlt":[{"subitem_alternative_title":"The Expression of Toll-like Receptor 4 in Bladder Cancer","subitem_alternative_title_language":"en"},{"subitem_alternative_title":"Toll様受容体4の低発現は膀胱癌の予後不良と関連する","subitem_alternative_title_language":"ja"}]},"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2019-02-02","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"711","bibliographicPageStart":"703","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"Anticancer Research","bibliographic_titleLang":"en"}]}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aim: The aim of this study was to elucidate the relationship between the progression of bladder cancer (BCa) and TLR4 expression. Materials and Methods: The relationship between TLR4 expression and prognosis of BCa patients was analyzed using a publicly available database and immunohistochemical staining of clinical samples. The effect of TLR4 knockdown was also examined on the invasive capabilities of BCa cells. Finally, to investigate the biological function of TLR4, the gene expression profile of TLR4-depleted BCa cells was analyzed by microarray analysis. Results: Expression of TLR4 was inversely associated with prognosis of patients with invasive BCa, and depletion of TLR4 significantly enhanced the invasive capability of BCa cells. Gene expression profiling revealed that depletion of TLR4 led to high expression of epithelial differentiation genes. Furthermore, expression of TLR4 was found to be extremely low in areas of squamous differentiation. Conclusion: Low TLR4 expression was correlated with tumor progression.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Institute of Anticancer Research","subitem_publisher_language":"en"}]},"item_10001_source_id_9":{"attribute_name":"収録物ID","attribute_value_mlt":[{"subitem_source_identifier":"02507005","subitem_source_identifier_type":"PISSN"},{"subitem_source_identifier":"17917530","subitem_source_identifier_type":"EISSN"},{"subitem_source_identifier":"AA10625860","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"AA12440673","subitem_source_identifier_type":"NCID"}]},"item_10001_version_type_20":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_1714461018643":{"attribute_name":"報告番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第3864号"}]},"item_1714461102074":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_1714461118377":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2025-02-27"}]},"item_1714461137393":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"徳島大学"}]}]},"item_1715043197608":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_1718868208704":{"attribute_name":"備考","attribute_value_mlt":[{"subitem_textarea_language":"ja","subitem_textarea_value":"内容要旨・審査要旨・論文本文の公開\n本論文は，著者YOSHITO KUSUHARAの学位論文として提出され，学位審査・授与の対象となっている。\n学位授与者所属 : 徳島大学大学院医学研究科（医学専攻）"}]},"item_1718868303842":{"attribute_name":"学位記番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲医第1627号"}]},"item_1722929371688":{"attribute_name":"出版社版DOI","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_language":"ja","subitem_relation_name_text":"10.21873/anticanres.13166"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.21873/anticanres.13166","subitem_relation_type_select":"DOI"}}]},"item_1723180141928":{"attribute_name":"EID","attribute_value_mlt":[{"subitem_identifier_type":"URI","subitem_identifier_uri":"355460"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"楠原, 義人","creatorNameLang":"ja"},{"creatorName":"クスハラ, ヨシト","creatorNameLang":"ja-Kana"},{"creatorName":"Kusuhara, Yoshito","creatorNameLang":"en"}],"familyNames":[{"familyName":"楠原","familyNameLang":"ja"},{"familyName":"クスハラ","familyNameLang":"ja-Kana"},{"familyName":"Kusuhara","familyNameLang":"en"}],"givenNames":[{"givenName":"義人","givenNameLang":"ja"},{"givenName":"ヨシト","givenNameLang":"ja-Kana"},{"givenName":"Yoshito","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"711","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"277743/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/277743/profile-ja.html"},{"nameIdentifier":"40745684","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=40745684"}]},{"creatorNames":[{"creatorName":"大豆本, 圭","creatorNameLang":"ja"},{"creatorName":"ダイズモト, ケイ","creatorNameLang":"ja-Kana"},{"creatorName":"Daizumoto, Kei","creatorNameLang":"en"}],"familyNames":[{"familyName":"大豆本","familyNameLang":"ja"},{"familyName":"ダイズモト","familyNameLang":"ja-Kana"},{"familyName":"Daizumoto","familyNameLang":"en"}],"givenNames":[{"givenName":"圭","givenNameLang":"ja"},{"givenName":"ケイ","givenNameLang":"ja-Kana"},{"givenName":"Kei","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"960","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"350200/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/350200/profile-ja.html"},{"nameIdentifier":"10745516","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10745516"}]},{"creatorNames":[{"creatorName":"Kawai, Kaichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hirayama, Kento","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kowada, Minoru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shintani, Terumichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Fukuhara, Yayoi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Dondoo, Tsogt-Ochir","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ozaki, Keisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"津田, 恵","creatorNameLang":"ja"},{"creatorName":"ツダ, メグミ","creatorNameLang":"ja-Kana"},{"creatorName":"Tsuda, Megumi","creatorNameLang":"en"}],"familyNames":[{"familyName":"津田","familyNameLang":"ja"},{"familyName":"ツダ","familyNameLang":"ja-Kana"},{"familyName":"Tsuda","familyNameLang":"en"}],"givenNames":[{"givenName":"恵","givenNameLang":"ja"},{"givenName":"メグミ","givenNameLang":"ja-Kana"},{"givenName":"Megumi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"992","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30769188","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30769188"}]},{"creatorNames":[{"creatorName":"布川, 朋也","creatorNameLang":"ja"},{"creatorName":"フカワ, トモヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Fukawa, Tomoya","creatorNameLang":"en"}],"familyNames":[{"familyName":"布川","familyNameLang":"ja"},{"familyName":"フカワ","familyNameLang":"ja-Kana"},{"familyName":"Fukawa","familyNameLang":"en"}],"givenNames":[{"givenName":"朋也","givenNameLang":"ja"},{"givenName":"トモヤ","givenNameLang":"ja-Kana"},{"givenName":"Tomoya","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"519","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"229106/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/229106/profile-ja.html"},{"nameIdentifier":"70564342","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=70564342"}]},{"creatorNames":[{"creatorName":"Nakatsuji, Hiroyoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"坂東, 良美","creatorNameLang":"ja"},{"creatorName":"バンドウ, ヨシミ","creatorNameLang":"ja-Kana"},{"creatorName":"Bando, Yoshimi","creatorNameLang":"en"}],"familyNames":[{"familyName":"坂東","familyNameLang":"ja"},{"familyName":"バンドウ","familyNameLang":"ja-Kana"},{"familyName":"Bando","familyNameLang":"en"}],"givenNames":[{"givenName":"良美","givenNameLang":"ja"},{"givenName":"ヨシミ","givenNameLang":"ja-Kana"},{"givenName":"Yoshimi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1559","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60096/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60096/profile-ja.html"},{"nameIdentifier":"00238239","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=00238239"}]},{"creatorNames":[{"creatorName":"上原, 久典","creatorNameLang":"ja"},{"creatorName":"ウエハラ, ヒサノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Uehara, Hisanori","creatorNameLang":"en"}],"familyNames":[{"familyName":"上原","familyNameLang":"ja"},{"familyName":"ウエハラ","familyNameLang":"ja-Kana"},{"familyName":"Uehara","familyNameLang":"en"}],"givenNames":[{"givenName":"久典","givenNameLang":"ja"},{"givenName":"ヒサノリ","givenNameLang":"ja-Kana"},{"givenName":"Hisanori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1548","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60072/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60072/profile-ja.html"},{"nameIdentifier":"30263809","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=30263809"}]},{"creatorNames":[{"creatorName":"福森, 知治","creatorNameLang":"ja"},{"creatorName":"フクモリ, トモハル","creatorNameLang":"ja-Kana"},{"creatorName":"Fukumori, Tomoharu","creatorNameLang":"en"}],"familyNames":[{"familyName":"福森","familyNameLang":"ja"},{"familyName":"フクモリ","familyNameLang":"ja-Kana"},{"familyName":"Fukumori","familyNameLang":"en"}],"givenNames":[{"givenName":"知治","givenNameLang":"ja"},{"givenName":"トモハル","givenNameLang":"ja-Kana"},{"givenName":"Tomoharu","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1568","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"10314874","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10314874"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"高橋, 正幸","creatorNameLang":"ja"},{"creatorName":"タカハシ, マサユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Takahashi, Masayuki","creatorNameLang":"en"}],"familyNames":[{"familyName":"高橋","familyNameLang":"ja"},{"familyName":"タカハシ","familyNameLang":"ja-Kana"},{"familyName":"Takahashi","familyNameLang":"en"}],"givenNames":[{"givenName":"正幸","givenNameLang":"ja"},{"givenName":"マサユキ","givenNameLang":"ja-Kana"},{"givenName":"Masayuki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1557","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50325255","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=50325255"}]},{"creatorNames":[{"creatorName":"金山, 博臣","creatorNameLang":"ja"},{"creatorName":"カナヤマ, ヒロオミ","creatorNameLang":"ja-Kana"},{"creatorName":"Kanayama, Hiro-omi","creatorNameLang":"en"}],"familyNames":[{"familyName":"金山","familyNameLang":"ja"},{"familyName":"カナヤマ","familyNameLang":"ja-Kana"},{"familyName":"Kanayama","familyNameLang":"en"}],"givenNames":[{"givenName":"博臣","givenNameLang":"ja"},{"givenName":"ヒロオミ","givenNameLang":"ja-Kana"},{"givenName":"Hiro-omi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1546","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60070/profile-ja.html","nameIdentifierScheme":"徳島大学 教育研究者総覧","nameIdentifierURI":"http://pub2.db.tokushima-u.ac.jp/ERD/person/60070/profile-ja.html"},{"nameIdentifier":"10214446","nameIdentifierScheme":"e-Rad_Researcher","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?qm=10214446"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-04-25"}],"displaytype":"detail","filename":"k3864_abstract.pdf","filesize":[{"value":"137 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"abstract","url":"https://tokushima-u.repo.nii.ac.jp/record/2013193/files/k3864_abstract.pdf"},"version_id":"e87c856d-59cc-4c48-b4c9-88baee2c3906"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-04-25"}],"displaytype":"detail","filename":"k3864_review.pdf","filesize":[{"value":"116 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"other","url":"https://tokushima-u.repo.nii.ac.jp/record/2013193/files/k3864_review.pdf"},"version_id":"b2fd8a3c-e430-4f7a-b212-b884febd3874"},{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-04-25"}],"displaytype":"detail","filename":"k3864_fulltext.pdf","filesize":[{"value":"476 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"objectType":"fulltext","url":"https://tokushima-u.repo.nii.ac.jp/record/2013193/files/k3864_fulltext.pdf"},"version_id":"53d804f1-0b76-43cd-a94a-d95c0a5101fe"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Bladder cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Toll-like receptor 4","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"squamous differentiation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Low Expression of Toll-like Receptor 4 Is Associated With Poor Prognosis in Bladder Cancer","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Low Expression of Toll-like Receptor 4 Is Associated With Poor Prognosis in Bladder Cancer","subitem_title_language":"en"}]},"item_type_id":"40001","owner":"48","path":["1716268551628"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-04-25"},"publish_date":"2025-04-25","publish_status":"0","recid":"2013193","relation_version_is_last":true,"title":["Low Expression of Toll-like Receptor 4 Is Associated With Poor Prognosis in Bladder Cancer"],"weko_creator_id":"48","weko_shared_id":-1},"updated":"2025-05-29T04:19:52.107107+00:00"}