| Item type |
文献 / Documents(1) |
| 公開日 |
2025-06-02 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_db06 |
|
資源タイプ |
doctoral thesis |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.3390/ijms26052026 |
|
|
関連名称 |
10.3390/ijms26052026 |
| 出版タイプ |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| タイトル |
|
|
タイトル |
Urinary Titin on the First Postoperative Day Predicts Long-Term Skeletal Muscle Loss in Patients with Gastroenterological Cancer |
| タイトル別表記 |
|
|
その他のタイトル |
術後1日目の尿中タイチンは消化器がん患者の長期的な骨格筋量減少を予測する |
| 著者 |
京面, ももこ
Tatsumi, Ayako
堤, 理恵
Izumi-Mishima, Yuna
Hyodo, Mizusa
Tanaka, Eiji
Iguchi, Kohta
Taura, Kojiro
Terajima, Hiroaki
Honjo, Sachiko
Hamasaki, Akihiro
野村, 和弘
阪上, 浩
|
| 抄録 |
|
|
内容記述 |
Perioperative malnutrition is common in patients with gastroenterological cancer and contributes to postoperative skeletal muscle atrophy, which adversely affects their prognosis. Early assessment of skeletal muscle atrophy is crucial for improving postoperative outcomes. This study aimed to evaluate the efficacy of urinary titin as a biomarker for skeletal muscle atrophy. A prospective observational study was conducted, and a total of 34 gastroenterological cancer patients were included. Urinary titin levels were measured using ELISA at admission, postoperative days (POD) 1, 7, and 14, and at 6 months after surgery. Surgical procedure, operative time, cancer stage, postoperative complications, hospital stay, and preoperative and postoperative body composition were evaluated, along with nutritional status and grip strength from admission to 6 months after surgery. Changes in urinary titin levels were measured at the same time points as described above. Preoperatively, the mean urinary titin level was 5.03 pmol/mg Cr, slightly higher than in healthy subjects. Urinary titin peaked at 33.71 (24.30–66.58) pmol/mg/dL Cr on POD1 and was associated with serum free branched-chain amino acid concentrations. Urinary titin on POD1 was significantly correlated with a decrease in skeletal muscle mass (rs −0.361, p = 0.036) and body cell mass (rs −0.361, p = 0.038) at 6 months postoperatively. The grip strength at 6 months postoperatively tended to decrease (rs −0.342, p = 0.052). BMI and serum LDH at admission were associated with urinary titin on POD1 but were not correlated with skeletal muscle loss at 6 months, suggesting that urinary titin on POD1 is an independent biomarker of skeletal muscle atrophy. These data indicate that urinary titin on POD1 can predict long-term skeletal muscle atrophy. |
| キーワード |
|
|
主題 |
urinary titin |
| キーワード |
|
|
主題 |
skeletal muscle atrophy |
| キーワード |
|
|
主題 |
gastroenterological cancer |
| 書誌情報 |
en : International Journal of Molecular Sciences
巻 26,
号 5,
p. 2026,
発行日 2025-02-26
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
14220067 |
| 出版者 |
|
|
出版者 |
MDPI |
| 備考 |
|
|
値 |
内容要旨・審査要旨・論文本文の公開
本論文は，著者Momoko Kyomenの学位論文として提出され，学位審査・授与の対象となっている。
学位授与者所属 : 徳島大学大学院医科栄養学研究科（医科栄養学専攻） |
| 権利情報 |
|
|
権利情報 |
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
419412 |
| 言語 |
|
|
言語 |
eng |
| 報告番号 |
|
|
学位授与番号 |
甲第3914号 |
| 学位記番号 |
|
|
値 |
甲栄第319号 |
| 学位授与年月日 |
|
|
学位授与年月日 |
2025-03-27 |
| 学位名 |
|
|
学位名 |
博士（栄養学） |
| 学位授与機関 |
|
|
|
学位授与機関名 |
徳島大学 |
k3914_abstract.pdf (123 KB)
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