| Item type |
文献 / Documents(1) |
| 公開日 |
2025-06-11 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.2152/jmi.72.161 |
|
|
関連名称 |
10.2152/jmi.72.161 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Melanoma antigen is a vaccine candidate against Meth A sarcoma |
| タイトル別表記 |
|
|
その他のタイトル |
Melanoma antigen is a vaccine candidate antigen |
| 著者 |
中本, 晶子
Ohashi, Haruka
Tanaka, Yuko
Yamamoto, Mako
中本, 真理子
首藤, 恵泉
酒井, 徹
|
| 抄録 |
|
|
内容記述 |
Sarcoma Meth A is widely used in the field of immunology and oncology study. We found that a mutant cell line, Meth A (mMeth A), was rejected in an in vivo subcutaneous challenge in BALB / c mice. mMeth A cells were not rejected in athymic BALB / c-nu / nu mice and CD8+ cell-depleted BALB / c mice, suggesting that CD8+ cells are required for rejection of mMeth A cells. Microarray analysis showed that melanoma antigen (MAg) was one of the most elevated genes in mMeth A cells. Indeed, quantitative gene expression analysis showed that the expression level of MAg in mMeth A cells was one hundred-times higher than that in Meth A cells. We constructed two types of expression vector coding the MAg gene sequence corresponding to 788–1257 and 1611-2043 and immunized mice with these genes by intramuscular injection. Immunization of a plasmid expressing the Mag 788-1257 gene protected the mice from in vivo Meth A challenge as evaluated by tumor volume and survival rate. The results reveal that MAg is a potential vaccine candidate antigen against Meth A tumors. |
| キーワード |
|
|
主題 |
Meth A |
| キーワード |
|
|
主題 |
CD8+ cells |
| キーワード |
|
|
主題 |
melanoma antigen |
| キーワード |
|
|
主題 |
vaccine |
| 書誌情報 |
en : The Journal of Medical Investigation
巻 72,
号 1-2,
p. 161-166,
発行日 2025-02
|
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
13496867 |
| 収録物ID |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
13431420 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11166929 |
| 出版者 |
|
|
出版者 |
Tokushima University Faculty of Medicine |
| EID |
|
|
識別子 |
433634 |
| 言語 |
|
|
言語 |
eng |
jmi_72_1-2_161.pdf (1.9 MB)
