| Item type |
文献 / Documents(1) |
| 公開日 |
2025-08-12 |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
|
|
|
関連識別子 |
https://doi.org/10.1016/j.bbrc.2024.150918 |
|
|
関連名称 |
10.1016/j.bbrc.2024.150918 |
| 出版タイプ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| タイトル |
|
|
タイトル |
Urinary titin as an early biomarker of skeletal muscle proteolysis and atrophy in various catabolic conditions |
| 著者 |
Hyodo, Mizusa
野村, 和弘
堤, 理恵
和泉, 優奈
Kawaguchi, Hibiki
Kawakami, Ayuka
Hara, Kanako
Suzuki, Yuki
Shirakawa, Taku
Osawa, Kayo
Matsuo, Masafumi
阪上, 浩
|
| 抄録 |
|
|
内容記述 |
Skeletal muscle atrophy impairs quality of life and increases the risk of disease, but current methods for assessment of muscle mass have several limitations. We here investigated the urinary concentration of a fragment of the muscle protein titin as a potential biomarker for the early detection of skeletal muscle atrophy. Four mouse models with different atrophy pathways were studied: those of cardiotoxin-induced acute muscle injury, cast-induced muscle immobilization, lipopolysaccharide-induced sepsis, and streptozotocin-induced diabetes. In all four models, urinary titin levels increased early, concurrent with or preceding upregulation of the atrophy-related genes for atrogin-1 and MuRF-1. The increase in the urinary titin concentration was thus associated with initial muscle damage and the onset of proteolysis, rather than with late-stage muscle wasting. Our findings suggest that urinary titin is a promising biomarker for detection of the onset of skeletal muscle catabolism and prediction of the subsequent development of atrophy in different catabolic states. Noninvasive measurement of urinary titin may therefore allow the earlier detection of skeletal muscle proteolysis compared with conventional techniques. |
| キーワード |
|
|
主題 |
Titin |
| キーワード |
|
|
主題 |
Skeletal muscle |
| キーワード |
|
|
主題 |
Muscle atrophy |
| キーワード |
|
|
主題 |
Muscle catabolism |
| キーワード |
|
|
主題 |
Muscle inflammation |
| 書誌情報 |
en : Biochemical and Biophysical Research Communications
巻 737,
p. 150918,
発行日 2024-10-28
|
| 収録物ID |
|
|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0006291X |
| 収録物ID |
|
|
収録物識別子タイプ |
EISSN |
|
収録物識別子 |
10902104 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA11542044 |
| 収録物ID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00564395 |
| 出版者 |
|
|
出版者 |
Elsevier |
| 権利情報 |
|
|
権利情報 |
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| EID |
|
|
識別子 |
419214 |
| 言語 |
|
|
言語 |
eng |
bbrc_737_150918.pdf (4 MB)
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