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Involvement of AKR1C3-targeted compounds in spermatogenesis
https://tokushima-u.repo.nii.ac.jp/records/2013371
https://tokushima-u.repo.nii.ac.jp/records/2013371b41ca5b5-81e7-4422-a14c-ce48e217d021
| 名前 / ファイル | ライセンス | アクション |
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tehs_17_2_231.pdf (978 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||
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| 公開日 | 2025-07-24 | |||||||||||||||
| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 出版社版DOI | ||||||||||||||||
| 関連識別子 | https://doi.org/10.1007/s13530-025-00253-z | |||||||||||||||
| 関連名称 | 10.1007/s13530-025-00253-z | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Involvement of AKR1C3-targeted compounds in spermatogenesis | |||||||||||||||
| 著者 |
Kasahara, Akari
× Kasahara, Akari
× Fujita, Ayaka
× 長﨑, 裕加× 佐藤, 陽一
WEKO
1215
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| 内容記述 | Objective A genome-wide association study (GWAS) in the general Japanese male population suggested that the aldo-keto reductase family 1 member C3 (AKR1C3) gene was associated with sperm concentration. AKR1C3 is a metabolic enzyme in the testosterone synthesis pathway that may be involved in spermatogenesis. In this study, to determine the involvement of AKR1C3 in spermatogenesis, we examined the effects of AKR1C3 inhibitors and inducers on rat sperm count. Methods Indomethacin was used as an AKR1C3 inhibitor, and fenofibrate was used as an inducer. The rats were randomly divided into groups of nine, and indomethacin (1 mg/kg/d) and fenofibrate (20 mg/kg/d) were administered orally to 5-week-old male rats for 30 d. The control group received a 0.5% sodium carboxymethylcellulose solution. Sperm counts were measured at the end of the treatment. They were also mated with female rats, and the litter size was determined. Results At the end of treatment, sperm counts tended to be lower in the indomethacin group than in the control group. In contrast, sperm counts were significantly higher in the fenofibrate group than in the control group (p = 0.018). Litter size after mating with female rats was significantly reduced in the indomethacin group compared to the controls (p = 0.016). Conclusion Indomethacin, an inhibitor of AKR1C3, tended to decrease sperm count in rats, suggesting that AKR1C3 affects spermatogenesis. Fenofibrate, an inducer of AKR1C3, significantly increased sperm count in rats. Fenofibrate is a potential treatment for male infertility. |
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| キーワード | ||||||||||||||||
| 主題 | Sperm parameter | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | AKR1C3 | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | Indomethacin | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | Fenofibrate | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | Fertility | |||||||||||||||
| 書誌情報 |
en : Toxicology and Environmental Health Sciences 巻 17, 号 2, p. 231-237, 発行日 2025-02-04 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 22337784 | |||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 20059752 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Springer Nature | |||||||||||||||
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| 出版者 | Korean Society of Environmental Risk Assessment and Health Science | |||||||||||||||
| 備考 | ||||||||||||||||
| 値 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: https://doi.org/10.1007/s13530-025-00253-z | |||||||||||||||
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| 識別子 | 417179 | |||||||||||||||
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| 言語 | eng | |||||||||||||||
