WEKO3
アイテム
Molecular Mechanisms of Acute Radiation Intestinal Injury and Its Control
https://tokushima-u.repo.nii.ac.jp/records/2013373
https://tokushima-u.repo.nii.ac.jp/records/201337342c0ad25-7f4d-42f8-acde-3c843aa5055d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
rem_13_1_10.pdf (850 KB)
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| Item type | 文献 / Documents(1) | |||||||||||||||
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| 公開日 | 2025-07-31 | |||||||||||||||
| アクセス権 | ||||||||||||||||
| アクセス権 | open access | |||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 出版社版DOI | ||||||||||||||||
| 関連識別子 | https://doi.org/10.51083/radiatenvironmed.13.1_10 | |||||||||||||||
| 関連名称 | 10.51083/radiatenvironmed.13.1_10 | |||||||||||||||
| 出版タイプ | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Molecular Mechanisms of Acute Radiation Intestinal Injury and Its Control | |||||||||||||||
| 著者 |
森田, 明典
× 森田, 明典
WEKO
654
× 西山, 祐一× Sakai, Takuma
× Higashi, Yuichi
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| 抄録 | ||||||||||||||||
| 内容記述 | The intestinal tract is a representative radiosensitive tissue and a risk organ in radiotherapy that limits the prescribed dose to tumors in the abdominal and pelvic regions. High-dose radiation damage to intestinal tissue induces the loss of intestinal epithelial stem cells, and it is now becoming clear that this process consists of two steps: crypt cell death regulated by p53 and exacerbation caused by inflammatory immune responses. Transcriptional regulators that enhance p53 function without enhancing apoptosis are effective in controlling the first step. The common activity of these p53 modulators that promote such functions is that they are able to suppress apoptosis without impairing p21-mediated cell cycle arrest. Regulating the second step can be achieved by agonists of Toll-like receptor signaling pathways that enhance the priming signal of pyroptosis and inhibitors that suppress the activity of the inflammasome. In this review, we outline the molecular mechanisms of each process and discuss strategies for effectively controlling the acute radiation-induced gastrointestinal syndrome. | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | radioprotector | |||||||||||||||
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| 主題 | p53 | |||||||||||||||
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| 主題 | p53 modulator | |||||||||||||||
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| 主題 | inflammatory response | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | inflammation control | |||||||||||||||
| 書誌情報 |
en : Radiation Environment and Medicine 巻 13, 号 1, p. 10-18, 発行日 2024-02-28 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||
| 収録物識別子 | 2432163X | |||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||
| 収録物識別子 | 24239097 | |||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA12760776 | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Hirosaki University Press | |||||||||||||||
| EID | ||||||||||||||||
| 識別子 | 406041 | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
