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Marked enhancement of synergistic antioxidative activity of astaxanthin and curcumin by co-encapsulation in a liposomal formulation
https://tokushima-u.repo.nii.ac.jp/records/2013403
https://tokushima-u.repo.nii.ac.jp/records/2013403ff717444-4d29-4563-86ec-52706ff971c4
| 名前 / ファイル | ライセンス | アクション |
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jcbn.pdf (466 KB)
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| アイテムタイプ | 文献 / Documents(1) | |||||||||||||||||||||
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| 公開日 | 2025-09-12 | |||||||||||||||||||||
| アクセス権 | ||||||||||||||||||||||
| アクセス権 | open access | |||||||||||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 出版社版DOI | ||||||||||||||||||||||
| 関連識別子 | https://doi.org/10.3164/jcbn.25-53 | |||||||||||||||||||||
| 関連名称 | 10.3164/jcbn.25-53 | |||||||||||||||||||||
| 出版タイプ | ||||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Marked enhancement of synergistic antioxidative activity of astaxanthin and curcumin by co-encapsulation in a liposomal formulation | |||||||||||||||||||||
| 著者 |
Yamasaki, Minori
× Yamasaki, Minori
× 米田, 晋太朗
WEKO
1409
× Maoka, Takashi
× 小暮, 健太朗
WEKO
1139
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| 抄録 | ||||||||||||||||||||||
| 内容記述 | Natural antioxidants may help prevent oxidative stress-mediated aging. Astaxanthin (Asx) is a powerful antioxidant that has been used in various dietary supplements and cosmetics. Previously, we reported that combination of Asx with tocotrienol (T3) or capsaicin (Cap) exhibited synergistic antioxidative effects; however, the synergistic increase in activity was unremarkable. Herein, we employed curcumin (Cur) to more effectively enhance the antioxidant activity of Asx. The antioxidative activity of liposomes co-encapsulating Asx and Cur (Asx/Cur-lipo) showed effective synergism (activity increase of ~2). A shift in peak absorption suggested intermolecular interactions between Asx and Cur. Since synthetic Asx is a mixture of various stereoisomers, we examined the effect of Asx stereochemistry on the effective synergism by investigating liposomes prepared with 3R,3’R-form (Asx-R), and 3S,3’S-form (Asx-S). Antioxidative activities of Asx-R/Cur-lipo and Asx-S/Cur-lipo were evaluated. Only Asx-S/Cur-lipo exhibited a synergistic effect; however, the activity increase of Asx-S/Cur-lipo was lower than that of Asx/Cur-lipo. In conclusion, liposomes co-encapsulating a synthetic mixture of stereochemical isomers of Asx and Cur may be most potent in preventing oxidative stress-mediated aging. | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | astaxanthin | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | curcumin | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | liposomes | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | intermolecular interaction | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 主題 | synergism | |||||||||||||||||||||
| 書誌情報 |
en : Journal of Clinical Biochemistry and Nutrition 発行日 2025 |
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| 収録物識別子タイプ | EISSN | |||||||||||||||||||||
| 収録物識別子 | 18805086 | |||||||||||||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||||||||||||
| 収録物識別子 | 09120009 | |||||||||||||||||||||
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| 収録物識別子タイプ | NCID | |||||||||||||||||||||
| 収録物識別子 | AA10710201 | |||||||||||||||||||||
| 出版者 | ||||||||||||||||||||||
| 出版者 | Society for Free Radical Research Japan | |||||||||||||||||||||
| 権利情報 | ||||||||||||||||||||||
| 権利情報 | This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License. https://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||||||||||||||||||
| EID | ||||||||||||||||||||||
| 識別子 | 446633 | |||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||
