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アイテム
アレルギー性鼻炎の病態解明と新規治療法の開発
https://tokushima-u.repo.nii.ac.jp/records/2013407
https://tokushima-u.repo.nii.ac.jp/records/2013407e98d82c2-4622-4801-aaae-7363cd1a5d4a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
sam_81_1-2_25.pdf (1.8 MB)
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| アイテムタイプ | 文献 / Documents(1) | |||||||||||
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| 公開日 | 2025-08-27 | |||||||||||
| アクセス権 | ||||||||||||
| アクセス権 | open access | |||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 出版社版DOI | ||||||||||||
| 関連識別子 | https://doi.org/10.57444/shikokuactamedica.81.1.2_25 | |||||||||||
| 関連名称 | 10.57444/shikokuactamedica.81.1.2_25 | |||||||||||
| 出版タイプ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| タイトル | ||||||||||||
| タイトル | アレルギー性鼻炎の病態解明と新規治療法の開発 | |||||||||||
| タイトル別表記 | ||||||||||||
| その他のタイトル | Elucidation of the pathophysiology of allergic rhinitis and development of novel therapeutic strategies | |||||||||||
| 著者 |
北村, 嘉章
× 北村, 嘉章
WEKO
1265
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| 抄録 | ||||||||||||
| 内容記述 | Allergic rhinitis (AR) is a type I allergic disease of the nasal mucosa, characterized by sneezing, watery rhinorrhea, and nasal congestion. A recent epidemiological survey revealed that nearly half of the population develops AR in Japan. Histamine is a major chemical mediator that induces AR symptoms by binding to histamine H1 receptor (H1R) during the development of AR. We found that histamine-mediated stimulation of H1R induces upregulation of H1R gene expression through the activation of protein kinase Cδ, and that the elevated receptor expression levels in the nasal mucosa enhance histamine signaling, thereby exacerbating AR symptoms. Antihistamines not only block histamine signaling through H1R but also suppress histamine-induced upregulation of H1R transcriptional activation. Moreover, they exert a suppressive effect on basal H1R transcription in the absence of histamine, which may be part of their inverse agonist action. Recently, light-emitting diodes that emit energy at a wavelength of 310 nm, corresponding to narrowband-ultraviolet B (NB-UVB), have been developed, and these devices are small enough to be used for intranasal phototherapy. To develop a phototherapy using NB-UVB for the treatment of AR, we examined the effects of NB-UVB irradiation on H1R gene expression. Our findings demonstrated that low-dose NB-UVB irradiation suppressed PMA-induced upregulation of H1R mRNA in a wavelength-specific, dose-dependent, and reversible manner, without inducing apoptosis. We then conducted an in vivo study using a rat AR model. Our findings demonstrated that intranasal pre-irradiation with NB-UVB dose-dependently suppressed upregulation of H1R mRNA in the nasal mucosa, leading to the alleviation of nasal symptoms without causing DNA damage. These findings suggest that phototherapy with low-dose NB-UVB can be applied effectively and safely for the treatment of AR. Since phase I and early phase II clinical trials confirmed its safety, we are currently conducting an investigator-initiated clinical trial in patients with pollinosis. |
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| キーワード | ||||||||||||
| 主題 | allergic rhinitis | |||||||||||
| キーワード | ||||||||||||
| 主題 | histamine H1 receptor | |||||||||||
| キーワード | ||||||||||||
| 主題 | antihistamine | |||||||||||
| キーワード | ||||||||||||
| 主題 | inverse agonist | |||||||||||
| キーワード | ||||||||||||
| 主題 | narrowband-ultraviolet B | |||||||||||
| 書誌情報 |
ja : 四国医学雑誌 en : Shikoku Acta Medica 巻 81, 号 1-2, p. 25-32, 発行日 2025-06-27 |
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| 収録物ID | ||||||||||||
| 収録物識別子タイプ | EISSN | |||||||||||
| 収録物識別子 | 27583279 | |||||||||||
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| 収録物識別子タイプ | PISSN | |||||||||||
| 収録物識別子 | 00373699 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 徳島医学会 | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
