| アイテムタイプ |
文献 / Documents(1) |
| 公開日 |
2025-10-07 |
| アクセス権 |
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アクセス権 |
embargoed access |
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アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 出版社版DOI |
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関連識別子 |
https://doi.org/10.1002/lipd.70005 |
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関連名称 |
10.1002/lipd.70005 |
| 出版タイプ |
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出版タイプ |
AM |
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出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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タイトル |
Solubilization of Saturated Fatty Acids and Its Lysophosphatidylcholine by Complexation With Bovine Serum Albumin |
| タイトル別表記 |
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その他のタイトル |
Solubilization of SFA and LysoPtdCho |
| 著者 |
Ali, Hanif
Yamanishi, Mone
Tsuchiya, Miki
Hasi, Rumana Yesmin
松﨑, 元紀
齋尾, 智英
(中橋)粟飯原, 睦美
川上, 竜巳
田中, 保
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| 抄録 |
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内容記述 |
High plasma levels of saturated fatty acids (SFAs) are associated with lifestyle diseases such as atherosclerosis and diabetes, whereas the accumulation of very long-chain fatty acids (VLCFAs) is believed to be responsible for neuropathy in certain types of peroxisomal disorders. Despite their clinical relevance, the toxicity mechanisms of fatty acids (FAs) remain poorly understood, largely because of the challenges in solubilizing them for in vitro experiments. We recently developed a method to form stable complexes of FAs with bovine serum albumin (BSA) using isopropanol as the solvent. Here, we demonstrate the stability and concentration range of FA/BSA and lysophosphatidylcholine (LysoPtdCho)/BSA complexes prepared using this method. These complexes exhibit enhanced solubility, retain their biological activity in cellular uptake assays, and remain stable for up to 12 months. We believe that our method will contribute to a better understanding of the toxicity and metabolism of SFAs and SFA-LysoPtdChos, and offer new insights into their roles in metabolic diseases and peroxisomal disorders. |
| キーワード |
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主題 |
bovine serum albumin |
| キーワード |
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主題 |
lysophosphatidylcholine |
| キーワード |
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主題 |
saturated fatty acid |
| キーワード |
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主題 |
solubilization |
| キーワード |
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主題 |
very long-chain fatty acid |
| 書誌情報 |
en : Lipids
発行日 2025-09-12
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| 収録物ID |
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収録物識別子タイプ |
EISSN |
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収録物識別子 |
15589307 |
| 収録物ID |
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収録物識別子タイプ |
PISSN |
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収録物識別子 |
00244201 |
| 収録物ID |
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収録物識別子タイプ |
NCID |
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収録物識別子 |
AA00275467 |
| 出版者 |
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出版者 |
American Oil Chemists' Society |
| 出版者 |
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出版者 |
John Wiley & Sons |
| 備考 |
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値 |
This is the peer reviewed version of the following article: Hanif Ali, Mone Yamanishi, Miki Tsuchiya, Rumana Yesmin Hasi, Motonori Matsusaki, Tomohide Saio, Mutsumi Aihara, Ryushi Kawakami, Tamotsu Tanaka. (2025), Solubilization of Saturated Fatty Acids and Its Lysophosphatidylcholine by Complexation With Bovine Serum Albumin. Lipids, which has been published in final form at https://doi.org/10.1002/lipd.70005. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited. |
| EID |
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識別子 |
449398 |
| 言語 |
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言語 |
eng |
lipd.pdf (1.8 MB)
