| Item type |
文献 / Documents(1) |
| 公開日 |
2025-09-29 |
| アクセス権 |
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|
アクセス権 |
embargoed access |
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アクセス権URI |
http://purl.org/coar/access_right/c_f1cf |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 出版社版DOI |
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|
関連識別子 |
https://doi.org/10.1093/jb/mvaf055 |
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|
関連名称 |
10.1093/jb/mvaf055 |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| タイトル |
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|
タイトル |
Nucling, a stress-inducible protein associated with apoptosomes, is important for microglial polarization/activation in the brain neuroinflamation |
| タイトル別表記 |
|
|
その他のタイトル |
Nucling and microglial polarization |
| 著者 |
Pham, Tuan Anh
坂井, 隆志
Dang, Huy Van
Tran, Diem Hong
Shishido, Yuji
チャン, ホアンナム
福井, 清
|
| 抄録 |
|
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内容記述 |
Microglia, the central nervous system’s resident macrophages, are critical for immune defense, protecting neurons during infection. Their role in postnatal brain development, particularly after injury, remains unclear. Nucling, a protein up-regulated during cardiac muscle differentiation, regulates NF-κB, influencing apoptosis and cell proliferation. In this study, we examined the role of Nucling in microglial activation using wild-type (WT) and Nucling-knockout (KO) neonatal mice subjected to poly(I:C), a viral mimic. Poly(I:C) treatment increased Iba1-positive microglia in both genotypes; however, KO mice showed a significantly exaggerated response in both cortical and hippocampal regions. Furthermore, while pro-inflammatory M1 markers (iNOS, CD86, TNFα, IL-6) were upregulated in both WT and KO mice, the anti-inflammatory M2 marker Arginase 1 (Arg1) was induced in WT but significantly suppressed in KO mice, indicating impaired M2 polarization. These findings suggest Nucling is essential for maintaining microglial polarization, supporting immunological processes against pathogens, and aiding central nervous system development. |
| キーワード |
|
|
主題 |
Microglia |
| キーワード |
|
|
主題 |
Nucling |
| キーワード |
|
|
主題 |
neuroinflammation |
| キーワード |
|
|
主題 |
M1/M2 phenotype |
| 書誌情報 |
en : The Journal of Biochemistry
発行日 2025-09-10
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| 収録物ID |
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収録物識別子タイプ |
EISSN |
|
収録物識別子 |
17562651 |
| 収録物ID |
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|
収録物識別子タイプ |
PISSN |
|
収録物識別子 |
0021924X |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA12096002 |
| 収録物ID |
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|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00694073 |
| 出版者 |
|
|
出版者 |
Oxford University Press |
| 備考 |
|
|
値 |
This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Biochemistry following peer review. The version of record Tuan Anh Pham, Takashi Sakai, Huy Van Dang, Diem Hong Tran, Yuji Shishido, Nam Hoang Tran, Kiyoshi Fukui, Nucling, a stress-inducible protein associated with apoptosomes, is important for microglial polarization/activation in the brain neuroinflamation, The Journal of Biochemistry, is available online at: https://doi.org/10.1093/jb/mvaf055. |
| EID |
|
|
識別子 |
454162 |
| 言語 |
|
|
言語 |
eng |
jb.pdf (1.5 MB)
